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Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

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Only original articles, editorials, guidelines.

  • Asensio-Grau A, Ferriz-Jordán M, Hervás D, Heredia A, García-Hernández J, Garriga M, Masip E, Carmen Collado M, Andrés A, Ribes-Koninckx C, Calvo-Lerma J.

    Faecal lipid profile as a new marker of fat maldigestion, malabsorption and microbiota.

    PEDIATRIC RESEARCH . : .

    [doi:10.1038/s41390-024-03209-0]

  • Boattini M, Bianco G, Llorente LI, Acero LA, Nunes D, Seruca M, Mendes VS, Almeida A, Bastos P, Rodríguez-Villodres Á, Gascón AG, Halperin AV, Cantón R, Escartín MNL, González-López JJ, Floch P, Massip C, Chainier D, Barraud O, Dortet L, Cuzon G, Zancanaro C, Mizrahi A, Schade R, Rasmussen AN, Schønning K, Hamprecht A, Schaffarczyk L, Glöckner S, Rödel J, Kristóf K, Balonyi Á, Mancini S, Quiblier C, Fasciana T, Giammanco A, Paglietti B, Rubino S, Budimir A, Bedenic B, Rubic Z, Marinovic J, Gartzonika K, Christaki E, Mavromanolaki VE, Maraki S, Yalçin TY, Azap ÖK, Licker M, Musuroi C, Talapan D, Ovidiu VC, Comini S, Zalas-Wiecek P, Michalska A, Cavallo R, Cristino JM, Costa C.

    Enterobacterales carrying chromosomal AmpC ß-lactamases in Europe (EuESCPM): epidemiology and antimicrobial resistance burden from a cohort of 27 hospitals, 2020-2022.

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS . 63(5): 107115-107115. Number of citations: 2

    [doi:10.1016/j.ijantimicag.2024.107115]

  • Taylor-Salmon E, Hill V, Paul LM, Koch RT, Breban MI, Chaguza C, Sodeinde A, Warren JL, Bunch S, Cano N, Cone M, Eysoldt S, Garcia A, Gilles N, Hagy A, Heberlein L, Jaber R, Kassens E, Colarusso P, Davis A, Baudin S, Rico E, Mejía-Echeverri Á, Scott B, Stanek D, Zimler R, Muñoz-Jordán JL, Santiago GA, Adams LE, Paz-Bailey G, Spillane M, Katebi V, Paulino-Ramírez R, Mueses S, Peguero A, Sánchez N, Norman FF, Galán JC, Huits R, Hamer DH, Vogels CBF, Morrison A, Michael SF, Grubaugh ND.

    Travel surveillance uncovers dengue virus dynamics and introductions in the Caribbean.

    NATURE COMMUNICATIONS . 15(1): 3508-3508.

    [doi:10.1038/s41467-024-47774-8]

  • Silva V, Silva A, Barbero R, Romero M, Del Campo R, Caniça M, Cordeiro R, Igrejas G, Poeta P.

    Resistome, Virulome, and Clonal Variation in Methicillin-Resistant Staphylococcus aureus (MRSA) in Healthy Swine Populations: A Cross-Sectional Study.

    GENES . 15(5): .

    [doi:10.3390/genes15050532]

  • Monzón S, Varona S, Negredo A, Vidal-Freire S, Patiño-Galindo JA, Ferressini-Gerpe N, Zaballos A, Orviz E, Ayerdi O, Muñoz-Gómez A, Delgado-Iribarren A, Estrada V, García C, Molero F, Sánchez-Mora P, Torres M, Vázquez A, Galán JC, Torres I, Causse Del Río M, Merino-Diaz L, López M, Galar A, Cardeñoso L, Gutiérrez A, Loras C, Escribano I, Alvarez-Argüelles ME, Del Río L, Simón M, Meléndez MA, Camacho J, Herrero L, Jiménez P, Navarro-Rico ML, Jado I, Giannetti E, Kuhn JH, Sanchez-Lockhart M, Di Paola N, Kugelman JR, Guerra S, García-Sastre A, Cuesta I, Sánchez-Seco MP, Palacios G.

    Monkeypox virus genomic accordion strategies.

    NATURE COMMUNICATIONS . 15(1): 3059-3059. Number of citations: 1

    [doi:10.1038/s41467-024-46949-7]

  • Levin BR, Berryhill BA, Gil-Gil T, Manuel JA, Smith AP, Choby JE, Andersson DI, Weiss DS, Baquero F.

    Theoretical considerations and empirical predictions of the pharmaco- and population dynamics of heteroresistance.

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA . 121(16): .

    [doi:10.1073/pnas.2318600121]

  • Castillo-Polo JA, Hernández-García M, Maruri-Aransolo A, de la Vega C, Ruiz-Garbajosa P, Cantón R.

    Evolution of ceftazidime-avibactam and cefiderocol resistance in ST131-H30R1-Escherichia coli isolates with KPC-3 mutants and application of FTIR biotyping.

    Microbiology spectrum . 12(4): .

    [doi:10.1128/spectrum.02776-23]

  • Ismail AS, Berryhill BA, Gil-Gil T, Manuel JA, Smith AP, Baquero F, Levin BR.

    The Tradeoffs Between Persistence and Mutation Rates at Sub-Inhibitory Antibiotic Concentrations in Staphylococcus aureus.

    Biorxiv : The Preprint Server For Biology . : .

    [doi:10.1101/2024.04.01.587561]

  • Ruiz-Galiana, Julian, Canton, Rafael, De Lucas Ramos, Pilar, Garcia-Botella, Alejandra, Garcia-Lledo, Alberto, Hernandez-Sampelayo, Teresa, Gomez-Pavon, Javier, Gonzalez del Castillo, Juan, Martin-Delgado, Mari Cruz, Martin Sanchez, Francisco Javier, Martinez-Selles, Manuel, Molero Garcia, Jose Maria, Moreno Guillen, Santiago, Rodriguez-Artalejo, Fernando, Rodriguez Fernandez, Rosa, Kestler, Marta, Bouza, Emilio.

    Respiratory syncytial virus: A new era

    REVISTA ESPANOLA DE QUIMIOTERAPIA . 37(2): 134-148.

    [doi:10.37201/req/147.2023]

  • Bosch-Nicolau P, Fernández ML, Sulleiro E, Villar JC, Perez-Molina JA, Correa-Oliveira R, Sosa-Estani S, Sánchez-Montalvá A, Del Carmen Bangher M, Moreira OC, Salvador F, Mota Ferreira A, Eloi-Santos SM, Serre-Delcor N, Ramírez JC, Silgado A, Oliveira I, Martín O, Aznar ML, Ribeiro ALP, Almeida PEC, Chamorro-Tojeiro S, Espinosa-Pereiro J, de Paula AMB, Váquiro-Herrera E, Tur C, Molina I.

    Efficacy of three benznidazole dosing strategies for adults living with chronic Chagas disease (MULTIBENZ): an international, randomised, double-blind, phase 2b trial.

    LANCET INFECTIOUS DISEASES . 24(4): 386-394. Number of citations: 3

    [doi:10.1016/S1473-3099(23)00629-1]

  • Hernandez-Beltran JCR, Rodríguez-Beltrán J, Aguilar-Luviano OB, Velez-Santiago J, Mondragón-Palomino O, MacLean RC, Fuentes-Hernández A, San Millán A, Peña-Miller R.

    Plasmid-mediated phenotypic noise leads to transient antibiotic resistance in bacteria.

    NATURE COMMUNICATIONS . 15(1): 2610-2610.

    [doi:10.1038/s41467-024-45045-0]

  • Baquero F, Beis K, Craik DJ, Li Y, Link AJ, Rebuffat S, Salomón R, Severinov K, Zirah S, Hegemann JD.

    The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide.

    NATURAL PRODUCT REPORTS . 41(3): 469-511. Number of citations: 4

    [doi:10.1039/d3np00046j]

  • Sturm A, Józwiak G, Verge MP, Munch L, Cathomen G, Vocat A, Luraschi-Eggemann A, Orlando C, Fromm K, Delarze E, Swiatkowski M, Wielgoszewski G, Totu RM, García-Castillo M, Delfino A, Tagini F, Kasas S, Lass-Flörl C, Gstir R, Cantón R, Greub G, Cichocka D.

    Accurate and rapid antibiotic susceptibility testing using a machine learning-assisted nanomotion technology platform.

    NATURE COMMUNICATIONS . 15(1): 2037-2037.

    [doi:10.1038/s41467-024-46213-y]

  • Moratiel-Pellitero A, Zapata-García M, Gascón-Ruiz M, Sesma A, Quílez E, Ramirez-Labrada A, Martínez-Lostao L, Domingo MP, Esteban P, Yubero A, Barbero-Herranz R, Moreno-Blanco A, Paño JR, Lastra R, Pardo J, Isla D, Del Campo R, Gálvez E.

    Biomarkers of Immunotherapy Response in Patients with Non-Small-Cell Lung Cancer: Microbiota Composition, Short-Chain Fatty Acids, and Intestinal Permeability.

    Cancers . 16(6): .

    [doi:10.3390/cancers16061144]

  • Roer L, Kaya H, Tedim AP, Novais C, Coque TM, Aarestrup FM, Peixe L, Hasman H, Hammerum AM, Freitas AR.

    VirulenceFinder for Enterococcus faecium and Enterococcus lactis: an enhanced database for detection of putative virulence markers by using whole-genome sequencing data.

    Microbiology spectrum . 12(3): . Number of citations: 1

    [doi:10.1128/spectrum.03724-23]

  • Fortún J, Gómez-García de la Pedrosa E, Martínez-Lorca A, Paredes P, Martín-Dávila P, Gómez-López A, Buitrago MJ, López-Jiménez J, Gioia F, Escudero R, Alvarez-Alvarez ME, Soriano C, Moreno-García J, San Miguel D, Vicente N, Moreno S.

    A Phase I/IIa Prospective, Randomized, Open-Label Study on the Safety and Efficacy of Nebulized Liposomal Amphotericin for Invasive Pulmonary Aspergillosis.

    JOURNAL OF FUNGI . 10(3): . Number of citations: 1

    [doi:10.3390/jof10030191]

  • Mesquida A, Alcoceba E, Padilla E, Ramírez A, Merino P, González-Romo F, De Carolis E, Sanguinetti M, Mantecón-Vallejo MLÁ, Muñoz-Algarra M, Durán-Valle T, Pérez-Ayala A, Gómez-García-de-la-Pedrosa E, Del Carmen Martínez-Jiménez M, Sánchez-Castellano MÁ, Quiles-Melero I, Cuétara MS, Sánchez-García A, Muñoz P, Escribano P, Guinea J.

    Fluconazole-resistant Candida parapsilosis genotypes from hospitals located in five Spanish cities and one in Italy: Description of azole-resistance profiles associated with the Y132F ERG11p substitution.

    Mycoses . 67(3): .

    [doi:10.1111/myc.13706]

  • de Aguirre PM, Carlos S, Pina-Sánchez M, Mbikayi S, Burgueño E, Tendobi C, Chiva L, Holguín Á, Reina G.

    High pre-Delta and early-Omicron SARS-CoV-2 seroprevalence detected in dried blood samples from Kinshasa (D.R. Congo).

    JOURNAL OF MEDICAL VIROLOGY . 96(3): 29529-29529. Number of citations: 1

    [doi:10.1002/jmv.29529]