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Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

Search for publications

Only original articles, editorials, guidelines.

  • Aguilar G, Ruiz-Garbajosa P, Periañez Parraga L, Maroto-Díaz M, de Ceano-Vivas MDC, Villacampa Lordan A, Arranz Gonzalo S, de Lossada Juste A, Moya-Alarcón C, Gheorghe M, Torre-Cisneros J.

    Cost-Effectiveness Analysis of Aztreonam-Avibactam Compared with Colistin Plus Meropenem in Treating Metallo-Beta-Lactamase-Producing Enterobacterales Infections in Spain

    Infectious diseases and therapy . 15(1): 265-284.

    [doi:10.1007/s40121-025-01257-5]

  • Turnidge, John, Kahlmeter, Gunnar, Giske, Christian G, Canton, Rafael, Matuschek, Erika, Wootton, Mandy, Gatermann, Soren.

    How To: The Application and Analysis of Categorical Agreement in Antimicrobial Susceptibility Testing using EUCAST Breakpoints.

    CLINICAL MICROBIOLOGY AND INFECTION . : .

    [doi:10.1016/j.cmi.2025.12.018]

  • Baquero, Fernando, Coque, Teresa M., Baston-Paz, Natalia, Perez-Cobas, Ana Elena.

    Biophysics of Bacterial Colonial Structures and the Occupancy of Microecological Spaces

    BIOLOGY-BASEL . 15(1): .

    [doi:10.3390/biology15010056]

  • García-Ortega A, Del-Campo-Moreno R, Sánchez V, Hervás-Marín D, Avendaño-Ortiz J, Rivas-Guerrero A, Muriel A, Pedro-Tudela A, Taberner-Lino L, De-Juana C, Barreiro E, Lobo-Beristain JL, Jiménez D, Otero Candelera R.

    Evaluation of microbial-derived metabolites in patients with acute pulmonary embolism: findings from the MICTEP study

    Erj Open Research . 11(6): .

    [doi:10.1183/23120541.00541-2025]

  • Rodriguez-Galet A, Ventosa-Cubillo J, Eyene M, Mikue-Owono T, Nzang J, Ncogo P, Benito A, Domínguez-García A, Holguín Á.

    Immunity to six vaccine pathogens in HIV positive and HIV negative children in Equatorial Guinea

    SCIENTIFIC REPORTS . 15(1): 45747-45747.

    [doi:10.1038/s41598-025-28643-w]

  • Diab Casares L, Espinosa Pereiro J, Tórtola Fernández MT, Casas García X, Millet JP, Pomar Solchaga V, Navas Elorza E, Troya García J, Díaz de Santiago A, Luque Márquez R, Medina Gallardo JF, González Galán V, Montero Alonso M, Gil Brusola A, Rabuñal Rey R, Anibarro García L, Sanz Herrero F, Guna Serrano R, Garrigó Fullola M, Tato Díez M, Talavan Zanón T, Portero MF, Alonso García P, Saez López AM, Aznar ML, Martínez Campreciós J, Saborit N, Sánchez Montalvá A.

    Multicentre controlled open randomised clinical trial to assess efficacy and safety of an anti-tuberculosis drug combination based on optimised-dose rifampicin, optimised-dose moxifloxacin and optimised-dose linezolid for TB: the RML-TB trial protocol

    BMJ Open Respiratory Research . 12(1): .

    [doi:10.1136/bmjresp-2024-002475]

  • de Morales, Alejandro G. Garcia-Ruiz, Vivancos, Maria Jesus, Romero-Hernandez, Beatriz, Rial-Crestelo, David, de las Revillas, Francisco Arnaiz, Sanchez-Villegas, Jorge, Alonso, Marta Montero, Sanchez, Maria De La Villa Lopez, Valls, Maria Remedios Aleman, Moreno, Santiago, Martinez-Sanz, Javier, Perez-Elias, Maria Jesus, CoRIS.

    Low-effort HIV training in Spanish primary care: Long-term impact on testing and diagnosis

    ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA . 43(10): 645-651.

    [doi:10.1016/j.eimc.2025.06.016]

  • García-Ruiz de Morales AG, Vivancos MJ, Romero-Hernández B, Rial-Crestelo D, Arnaiz de Las Revillas F, Sanchez-Villegas J, Montero Alonso M, López Sánchez MV, Alemán Valls MR, Moreno S, Martínez-Sanz J, Pérez-Elías MJ.

    Low-effort HIV training in Spanish primary care: Long-term impact on testing and diagnosis.

    Enfermedades Infecciosas Y Microbiologia Clinica (english Ed.) . 43(10): 645-651.

    [doi:10.1016/j.eimce.2025.06.015]

  • Ramirez de Arellano E, López-Causapé C, Delgado-Valverde M, Arroyo Muñoz FJ, Alemparte-Pardavila E, Arca-Suárez J, Ayestarán I, Calvo Montes J, Cañada-Garcia J, Garcia-Cobos S, García-Fernández S, Gijón Cordero D, González-López JJ, Mir-Cros A, Nuvials X, Pérez-Vázquez M, Pomares-de la Peña A, Pampín-Garcia M, Riazzo C, Rodríguez-Gómez J, Rojo-Molinero E, Ruiz-Garbajosa P, Soriano C, Suberviola Cañas B, Taltavull B, Garnacho-Montero J, Oliver Palomo A, Oteo-Iglesias J.

    Multidrug-resistant gram-negative bacteria in Spanish ICU patients: clinical and microbiological characterization (MURAN-UCI Project)

    Microbiology spectrum . : .

    [doi:10.1128/spectrum.02987-25]

  • Fernández-Garcia L, Blasco L, Bleriot I, Arman L, Ibarguren-Quiles C, Barrio-Pujante A, de Aledo MG, García-Contreras R, Cantón R, Wood TK, Tomas M.

    Phages and quorum sensing: findings to consider in phage therapy

    EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES . : .

    [doi:10.1007/s10096-025-05375-3]

  • Blanco-Martín T, Guzmán-Puche J, Hernández-García M, Muñoz-Rosa M, Elías-López C, Riazzo C, Torre-Cisneros J, Arca-Suárez J, Causse M, Bou G, Cantón R, Martínez-Martínez L.

    Mechanisms of resistance to ceftazidime/avibactam in mutants derived in vitro from Klebsiella pneumoniae producing OXA-48-like enzymes

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY . 80(12): 3265-3272.

    [doi:10.1093/jac/dkaf360]

  • Espinosa-Del-Barrio L, Gómez G de la Pedrosa E, Álvarez-Díaz N, Guzmán Martínez J, Corbacho Loarte MD, Escudero Sánchez R, Martín-Dávila P, Fortún Abete J, Cobo Reinoso J, Pintado García V, Gioia F.

    Aspergillus Endocarditis in Native Valves in Non-Traditional Hosts: A Systematic Review of a Case in a Patient with CREST Syndrome and Advanced Liver Cirrhosis.

    JOURNAL OF FUNGI . 11(12): .

    [doi:10.3390/jof11120836]

  • Álvarez Merino M, Cárdenes CML, Cavia SM, Rubio ET, Rodríguez-Martínez A, Santamaría SV, Torne CV, Beltrán MÁ, Galindo CG, Garriga García M, Alonso AM, Hurtado MM, Sierra San Nicolás S, Ortiz-Pérez P, Gutiérrez Martínez JR, González MS, Jiménez DG, Martín JJD.

    Impact on Body Composition After Two Years of Elexacaftor-Tezacaftor-Ivacaftor Therapy in Children with Cystic Fibrosis.

    Children-Basel . 12(12): .

    [doi:10.3390/children12121598]

  • Blanco JR, Del Campo R, Avendaño-Ortiz J, Laguna-Olmos M, Carnero A.

    The Role of Microbiota in Ovarian Cancer: Implications for Treatment Response and Therapeutic Strategies

    Cells . 14(22): .

    [doi:10.3390/cells14221813]

  • Guadarrama-Orozco KD, Esquivel-Hernández DA, Islas-Tolentino MÁ, Husain FM, Quezada H, García-Reyes S, Franco B, Marroquin-Mendiola DL, Lucero-Gil MG, Olvera-Falfan LP, Estrada-Velasco ÁY, Fabián Del Olmo MJ, Cocotl-Yañez M, Tomas M, Peña-Ocaña BA, Maeda T, Khan A, Arshad M, Cantón R, Oliver A, Kidd TJ, Valdez A, Cadet F, Toya S, Fontaine N, Ceapa CD, Kirigo J, Wood TK, García-Contreras R.

    Challenging the paradigm: non-canonical exoprotease cheating in clinical Pseudomonas aeruginosa isolates

    FEMS MICROBIOLOGY ECOLOGY . 101(11): .

    [doi:10.1093/femsec/fiaf106]

  • Gayoso Cantero D, Fernández-González P, Chamorro-Tojeiro S, Quereda C, Tato M, Berna-Rico E, Naharro-Rodríguez J, Perez-Molina JA.

    Clinical, therapeutic, and stigma-related challenges in leprosy and the emerging role of apremilast in managing leprosy reactions

    TRAVEL MEDICINE AND INFECTIOUS DISEASE . 68: 102918-102918.

    [doi:10.1016/j.tmaid.2025.102918]

  • Bastón-Paz N, Moreno-Blanco A, Palacios E, Olavarrieta L, Galeano J, Garriga M, Máiz L, Vicente-Santamaría S, Oteo-Iglesias J, López-Causapé C, Fuentes I, Oliver A, Cantón R, del Campo R, de Dios-Caballero J.

    Exploring the complexities of intestinal and pulmonary microbiota in cystic fibrosis: A multi-omics approach

    RESPIRATORY MEDICINE . 248: 108331-108331.

    [doi:10.1016/j.rmed.2025.108331]

  • Valadés-Alcaraz A, Medina-Sánchez C, Reinosa R, Ventosa-Cubillo J, Ventosa-Cubillo V, Holguín Á.

    Design and characterisation of high-affinity aptamers for detecting HIV integrase

    ANALYTICA CHIMICA ACTA . 1373: 344545-344545.

    [doi:10.1016/j.aca.2025.344545]