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Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

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Only original articles, editorials, guidelines.

  • Herencias C, Álvaro-Llorente L, Ramiro-Martínez P, Fernández-Calvet A, Muñoz-Cazalla A, DelaFuente J, Graf FE, Jaraba-Soto L, Castillo-Polo JA, Cantón R, San Millán Á, Rodríguez-Beltrán J.

    ß-lactamase expression induces collateral sensitivity in Escherichia coli.

    NATURE COMMUNICATIONS . 15(1): 4731-4731.

    [doi:10.1038/s41467-024-49122-2]

  • Aracil-Gisbert S, Fernández-de-Bobadilla MD, Guerra-Pinto N, Serrano-Calleja S, Pérez-Cobas AE, Soriano C, de Pablo R, Lanza VF, Pérez-Viso B, Reuters S, Hasman H, Cantón R, Baquero F, Coque TM.

    The ICU environment contributes to the endemicity of the "Serratia marcescens complex" in the hospital setting.

    Mbio . 15(5): .

    [doi:10.1128/mbio.03054-23]

  • Taylor-Salmon E, Hill V, Paul LM, Koch RT, Breban MI, Chaguza C, Sodeinde A, Warren JL, Bunch S, Cano N, Cone M, Eysoldt S, Garcia A, Gilles N, Hagy A, Heberlein L, Jaber R, Kassens E, Colarusso P, Davis A, Baudin S, Rico E, Mejía-Echeverri Á, Scott B, Stanek D, Zimler R, Muñoz-Jordán JL, Santiago GA, Adams LE, Paz-Bailey G, Spillane M, Katebi V, Paulino-Ramírez R, Mueses S, Peguero A, Sánchez N, Norman FF, Galán JC, Huits R, Hamer DH, Vogels CBF, Morrison A, Michael SF, Grubaugh ND.

    Travel surveillance uncovers dengue virus dynamics and introductions in the Caribbean.

    NATURE COMMUNICATIONS . 15(1): 3508-3508.

    [doi:10.1038/s41467-024-47774-8]

  • Monzón S, Varona S, Negredo A, Vidal-Freire S, Patiño-Galindo JA, Ferressini-Gerpe N, Zaballos A, Orviz E, Ayerdi O, Muñoz-Gómez A, Delgado-Iribarren A, Estrada V, García C, Molero F, Sánchez-Mora P, Torres M, Vázquez A, Galán JC, Torres I, Causse Del Río M, Merino-Diaz L, López M, Galar A, Cardeñoso L, Gutiérrez A, Loras C, Escribano I, Alvarez-Argüelles ME, Del Río L, Simón M, Meléndez MA, Camacho J, Herrero L, Jiménez P, Navarro-Rico ML, Jado I, Giannetti E, Kuhn JH, Sanchez-Lockhart M, Di Paola N, Kugelman JR, Guerra S, García-Sastre A, Cuesta I, Sánchez-Seco MP, Palacios G.

    Monkeypox virus genomic accordion strategies.

    NATURE COMMUNICATIONS . 15(1): 3059-3059.

    [doi:10.1038/s41467-024-46949-7]

  • Levin BR, Berryhill BA, Gil-Gil T, Manuel JA, Smith AP, Choby JE, Andersson DI, Weiss DS, Baquero F.

    Theoretical considerations and empirical predictions of the pharmaco- and population dynamics of heteroresistance.

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA . 121(16): .

    [doi:10.1073/pnas.2318600121]

  • Hernandez-Beltran JCR, Rodríguez-Beltrán J, Aguilar-Luviano OB, Velez-Santiago J, Mondragón-Palomino O, MacLean RC, Fuentes-Hernández A, San Millán A, Peña-Miller R.

    Plasmid-mediated phenotypic noise leads to transient antibiotic resistance in bacteria.

    NATURE COMMUNICATIONS . 15(1): 2610-2610.

    [doi:10.1038/s41467-024-45045-0]

  • Sturm A, Józwiak G, Verge MP, Munch L, Cathomen G, Vocat A, Luraschi-Eggemann A, Orlando C, Fromm K, Delarze E, Swiatkowski M, Wielgoszewski G, Totu RM, García-Castillo M, Delfino A, Tagini F, Kasas S, Lass-Flörl C, Gstir R, Cantón R, Greub G, Cichocka D.

    Accurate and rapid antibiotic susceptibility testing using a machine learning-assisted nanomotion technology platform.

    NATURE COMMUNICATIONS . 15(1): 2037-2037.

    [doi:10.1038/s41467-024-46213-y]

  • Moratiel-Pellitero A, Zapata-García M, Gascón-Ruiz M, Sesma A, Quílez E, Ramirez-Labrada A, Martínez-Lostao L, Domingo MP, Esteban P, Yubero A, Barbero-Herranz R, Moreno-Blanco A, Paño JR, Lastra R, Pardo J, Isla D, Del Campo R, Gálvez E.

    Biomarkers of Immunotherapy Response in Patients with Non-Small-Cell Lung Cancer: Microbiota Composition, Short-Chain Fatty Acids, and Intestinal Permeability.

    Cancers . 16(6): .

    [doi:10.3390/cancers16061144]

  • Fortún J, Gómez-García de la Pedrosa E, Martínez-Lorca A, Paredes P, Martín-Dávila P, Gómez-López A, Buitrago MJ, López-Jiménez J, Gioia F, Escudero R, Alvarez-Alvarez ME, Soriano C, Moreno-García J, San Miguel D, Vicente N, Moreno S.

    A Phase I/IIa Prospective, Randomized, Open-Label Study on the Safety and Efficacy of Nebulized Liposomal Amphotericin for Invasive Pulmonary Aspergillosis.

    JOURNAL OF FUNGI . 10(3): .

    [doi:10.3390/jof10030191]

  • Mesquida A, Alcoceba E, Padilla E, Ramírez A, Merino P, González-Romo F, De Carolis E, Sanguinetti M, Mantecón-Vallejo MLÁ, Muñoz-Algarra M, Durán-Valle T, Pérez-Ayala A, Gómez-García-de-la-Pedrosa E, Del Carmen Martínez-Jiménez M, Sánchez-Castellano MÁ, Quiles-Melero I, Cuétara MS, Sánchez-García A, Muñoz P, Escribano P, Guinea J.

    Fluconazole-resistant Candida parapsilosis genotypes from hospitals located in five Spanish cities and one in Italy: Description of azole-resistance profiles associated with the Y132F ERG11p substitution.

    Mycoses . 67(3): .

    [doi:10.1111/myc.13706]

  • de Aguirre PM, Carlos S, Pina-Sánchez M, Mbikayi S, Burgueño E, Tendobi C, Chiva L, Holguín Á, Reina G.

    High pre-Delta and early-Omicron SARS-CoV-2 seroprevalence detected in dried blood samples from Kinshasa (D.R. Congo).

    JOURNAL OF MEDICAL VIROLOGY . 96(3): .

    [doi:10.1002/jmv.29529]

  • Gutiérrez-Gálvez L, García-Fernández D, Barrio MD, Luna M, Torres Í, Zamora F, Navío C, Milán-Rois P, Castellanos M, Abreu M, Cantón R, Galán JC, Somoza Á, Miranda R, García-Mendiola T, Lorenzo E.

    Free PCR virus detection via few-layer bismuthene and tetrahedral DNA nanostructured assemblies

    Talanta . 269: 125405-125405.

    [doi:10.1016/j.talanta.2023.125405]

  • Pascual S, Noble B, Ahmad-Saeed N, Aldridge C, Ambretti S, Amit S, Annett R, O'Shea SA, Barbui AM, Barlow G, Barrett L, Berth M, Bondi A, Boran N, Boyd SE, Chaves C, Clauss M, Davies P, Dianzo-Delgado IT, Esteban J, Fuchs S, Friis-Hansen L, Goldenberger D, Golle A, Groonroos JO, Hoffmann I, Hoffmann T, Hughes H, Ivanova M, Jezek P, Jones G, Ceren Karahan Z, Lass-Flörl C, Laurent F, Leach L, Horsbøll Pedersen ML, Loiez C, Lynch M, Maloney RJ, Marsh M, Milburn O, Mitchell S, Moore LSP, Moffat L, Murdjeva M, Murphy ME, Nayar D, Nigrisoli G, O'Sullivan F, Öz B, Peach T, Petridou C, Prinz M, Rak M, Reidy N, Rossolini GM, Roux AL, Ruiz-Garbajosa P, Saeed K, Salar-Vidal L, Salas Venero C, Selvaratnam M, Senneville E, Starzengruber P, Talbot B, Taylor V, Trebše R, Wearmouth D, Willinger B, Wouthuyzen-Bakker M, Couturier B, Allantaz F.

    Potential value of a rapid syndromic multiplex PCR for the diagnosis of native and prosthetic joint infections: a real-world evidence study.

    Journal Of Bone And Joint Infection . 9(1): 87-97.

    [doi:10.5194/jbji-9-87-2024]

  • Rodríguez-Artalejo FJ, Ruiz-Galiana J, Cantón R, De Lucas Ramos P, García-Botella A, García-Lledó A, Hernández-Sampelayo T, Gómez-Pavón J, González Del Castillo J, Martín-Delgado MC, Martín Sánchez FJ, Martínez-Sellés M, Molero García JM, Moreno Guillén S, García de Viedma D, Bouza E.

    COVID-19: On the threshold of the fifth year. The situation in Spain.

    REVISTA ESPANOLA DE QUIMIOTERAPIA . 37(1): 17-28.

    [doi:10.37201/req/123.2023]

  • Soriano-Martín A, Muñoz P, García-Rodríguez J, Cantón R, Vena A, Bassetti M, Bouza E.

    Unresolved issues in the diagnosis of catheter related candidemia: A position paper.

    REVISTA ESPANOLA DE QUIMIOTERAPIA . 37(1): 1-16.

    [doi:10.37201/req/112.2023]

  • Paniagua-García M, Bravo-Ferrer JM, Pérez-Galera S, Kostyanev T, de Kraker MEA, Feifel J, Palacios-Baena ZR, Schotsman J, Cantón R, Daikos GL, Carevic B, Dragovac G, Tan LK, Raka L, Hristea A, Viale P, Akova M, Cano Á, Reguera JM, Bartoloni A, Florescu SA, Benea S, Bukarica L, Asensio Á, Korten V, Grundmann H, Goossens H, Bonten MJ, Gutiérrez-Gutiérrez B, Rodríguez-Baño J.

    Attributable mortality of infections caused by carbapenem-resistant Enterobacterales: results from a prospective, multinational case-control-control matched cohorts study (EURECA).

    CLINICAL MICROBIOLOGY AND INFECTION . 30(2): 223-230.

    [doi:10.1016/j.cmi.2023.11.008]

  • Mateos-Nozal J, Rodríguez-Domínguez M, San Román J, Candel FJ, Villarrubia N, Pérez-Panizo N, Segura E, Cuñarro JM, Ramírez-Arellano MVM, Rodríguez-Ramos R, Pariente-Rodríguez R, Villar LM, Ramos P, Cantón R, Cruz-Jentoft AJ, Galán JC.

    Factors Associated with SARS-CoV-2 Infection in Fully Vaccinated Nursing Home Residents and Workers.

    VIRUSES-BASEL . 16(2): .

    [doi:10.3390/v16020186]

  • Baquero F, Rodríguez-Beltrán J, Coque TM, Del Campo R.

    Boosting Fitness Costs Associated with Antibiotic Resistance in the Gut: On the Way to Biorestoration of Susceptible Populations.

    Biomolecules . 14(1): .

    [doi:10.3390/biom14010076]