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Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

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Only original articles, editorials, guidelines.

  • Fernández-Garcia L, Blasco L, Bleriot I, Arman L, Ibarguren-Quiles C, Barrio-Pujante A, de Aledo MG, García-Contreras R, Cantón R, Wood TK, Tomas M.

    Phages and quorum sensing: findings to consider in phage therapy

    EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES . : .

    [doi:10.1007/s10096-025-05375-3]

  • Blanco-Martín T, Guzmán-Puche J, Hernández-García M, Muñoz-Rosa M, Elías-López C, Riazzo C, Torre-Cisneros J, Arca-Suárez J, Causse M, Bou G, Cantón R, Martínez-Martínez L.

    Mechanisms of resistance to ceftazidime/avibactam in mutants derived in vitro from Klebsiella pneumoniae producing OXA-48-like enzymes

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY . 80(12): 3265-3272.

    [doi:10.1093/jac/dkaf360]

  • Espinosa-Del-Barrio L, Gómez G de la Pedrosa E, Álvarez-Díaz N, Guzmán Martínez J, Corbacho Loarte MD, Escudero Sánchez R, Martín-Dávila P, Fortún Abete J, Cobo Reinoso J, Pintado García V, Gioia F.

    Aspergillus Endocarditis in Native Valves in Non-Traditional Hosts: A Systematic Review of a Case in a Patient with CREST Syndrome and Advanced Liver Cirrhosis.

    JOURNAL OF FUNGI . 11(12): .

    [doi:10.3390/jof11120836]

  • Álvarez Merino M, Cárdenes CML, Cavia SM, Rubio ET, Rodríguez-Martínez A, Santamaría SV, Torne CV, Beltrán MÁ, Galindo CG, Garriga García M, Alonso AM, Hurtado MM, Sierra San Nicolás S, Ortiz-Pérez P, Gutiérrez Martínez JR, González MS, Jiménez DG, Martín JJD.

    Impact on Body Composition After Two Years of Elexacaftor-Tezacaftor-Ivacaftor Therapy in Children with Cystic Fibrosis.

    Children-Basel . 12(12): .

    [doi:10.3390/children12121598]

  • Blanco JR, Del Campo R, Avendaño-Ortiz J, Laguna-Olmos M, Carnero A.

    The Role of Microbiota in Ovarian Cancer: Implications for Treatment Response and Therapeutic Strategies

    Cells . 14(22): .

    [doi:10.3390/cells14221813]

  • Guadarrama-Orozco KD, Esquivel-Hernández DA, Islas-Tolentino MÁ, Husain FM, Quezada H, García-Reyes S, Franco B, Marroquin-Mendiola DL, Lucero-Gil MG, Olvera-Falfan LP, Estrada-Velasco ÁY, Fabián Del Olmo MJ, Cocotl-Yañez M, Tomas M, Peña-Ocaña BA, Maeda T, Khan A, Arshad M, Cantón R, Oliver A, Kidd TJ, Valdez A, Cadet F, Toya S, Fontaine N, Ceapa CD, Kirigo J, Wood TK, García-Contreras R.

    Challenging the paradigm: non-canonical exoprotease cheating in clinical Pseudomonas aeruginosa isolates

    FEMS MICROBIOLOGY ECOLOGY . 101(11): .

    [doi:10.1093/femsec/fiaf106]

  • Gayoso Cantero D, Fernández-González P, Chamorro-Tojeiro S, Quereda C, Tato M, Berna-Rico E, Naharro-Rodríguez J, Perez-Molina JA.

    Clinical, therapeutic, and stigma-related challenges in leprosy and the emerging role of apremilast in managing leprosy reactions

    TRAVEL MEDICINE AND INFECTIOUS DISEASE . 68: 102918-102918.

    [doi:10.1016/j.tmaid.2025.102918]

  • Bastón-Paz N, Moreno-Blanco A, Palacios E, Olavarrieta L, Galeano J, Garriga M, Máiz L, Vicente-Santamaría S, Oteo-Iglesias J, López-Causapé C, Fuentes I, Oliver A, Cantón R, del Campo R, de Dios-Caballero J.

    Exploring the complexities of intestinal and pulmonary microbiota in cystic fibrosis: A multi-omics approach

    RESPIRATORY MEDICINE . 248: 108331-108331.

    [doi:10.1016/j.rmed.2025.108331]

  • Valadés-Alcaraz A, Medina-Sánchez C, Reinosa R, Ventosa-Cubillo J, Ventosa-Cubillo V, Holguín Á.

    Design and characterisation of high-affinity aptamers for detecting HIV integrase

    ANALYTICA CHIMICA ACTA . 1373: 344545-344545.

    [doi:10.1016/j.aca.2025.344545]

  • Labiod N, Sánchez-Seco MP, Goikoetxea J, Zurita ND, Norman FF, Martínez MM, Alonso PA, Hernández-Betancor A, Sempere-Alcocer MA, Moure Z, Ocete MD, Vicente MR, de la Calle-Prieto F, Gallego M, Domingo LC, Galán JC, Camprubí-Ferrer D, Meilán C, Perez-Hernandez I, Cabezón I, Hernández FJ, Bernal E, Vázquez A.

    Case series of Oropouche fever among travellers returning from Cuba to Spain, 2024

    Eurosurveillance . 30(41): .

    [doi:10.2807/1560-7917.ES.2025.30.41.2400719]

  • Asensi-Díaz E, Barbero Del Olmo L, Urrutia P, Lario A, Gómez-G de la Pedrosa E, García-Ruiz de Morales AG, Martín-Dávila P, Fortún J.

    When Fungal Prophylaxis Fails: A Rare Case of Rhodotorula mucilaginosa Fungemia with Suspected Abdominal Origin

    JOURNAL OF FUNGI . 11(10): . Number of citations: 1

    [doi:10.3390/jof11100723]

  • Halperin AV, Escudero R, García-Castillo M, Cardenas-Isasi MJ, Gioia F, Cobo J, Sánchez-Díaz AM, Cantón R.

    Randomized controlled diagnostic trial to assess dRAST time to result and its utility for antimicrobial stewardship recommendation in bacteremic patients

    Microbiology spectrum . 13(10): . Number of citations: 1

    [doi:10.1128/spectrum.00288-25]

  • Canton R, Halperín AV.

    Diagnostic stewardship in sepsis: minding the gap from the microbiology lab to ward

    REVISTA ESPANOLA DE QUIMIOTERAPIA . 38(Suppl 1): 11-20.

    [doi:10.37201/req/s01.02.2025]

  • Rodriguez-Tierno S, Sáez de la Fuente J, Fuertes Pina L, Escudero-Sánchez R, Ruiz-Garbajosa P, Guijarro Martínez P, Gioia F, Pintor Recuenco MDR, Álvarez-Díaz A.

    Real-life experience with use of cefiderocol in non-critically ill patients in a tertiary care hospital.

    Enfermedades Infecciosas Y Microbiologia Clinica (english Ed.) . 43(8): 510-514.

    [doi:10.1016/j.eimce.2025.05.009]

  • Rico-Caballero V, Romero-Rivera M, Moreno-Blanco A, Aira A, Casals-Pascual C, Rodríguez-Jiménez C, Quereda C, Soriano A, Del Campo R.

    Fecal microbiota transplant as treatment for recurrent urinary tract infections: a proof-of-concept study

    EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES . 44(10): 2549-2554.

    [doi:10.1007/s10096-025-05202-9]

  • Daneri L, Urbano A, Escudero-Sánchez R, Halperin AV, Moreno-Blanco A, Corbacho MD, Suárez-Carantoña C, Rodríguez-Jiménez C, Serrano-Villar S, Campo RD, Cobo J.

    Lyophilised fecal microbiota transfer in capsules for recurrent Clostridioides difficile infection

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS . 66(4): 107561-107561.

    [doi:10.1016/j.ijantimicag.2025.107561]

  • Sastre-Femenia MÀ, Fernández-Muñoz A, Gomis-Font MA, Taltavull B, López-Causapé C, Arca-Suárez J, Martínez-Martínez L, Cantón R, Larrosa N, Oteo-Iglesias J, Oliver A.

    Spanish nationwide survey of Pseudomonas aeruginosa cefiderocol antimicrobial susceptibility and resistance genomics

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS . 66(4): 107563-107563. Number of citations: 2

    [doi:10.1016/j.ijantimicag.2025.107563]

  • Avendaño-Ortiz J, Tribaldo A, Ballestero L, Gómez LA, Gracia I, Rodríguez JF, Ramírez NB, Bodoque-Villar R, Vaz-Salgado MÁ, Del Campo R, Redondo-Calvo FJ.

    Antimicrobial Activity of Natural Extracts Against Catheter-Colonizing Methicillin-Resistant Staphylococcus aureus Clinical Isolates

    Biomedicines . 13(9): .

    [doi:10.3390/biomedicines13092150]