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Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

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Only original articles, editorials, guidelines.

  • Norman FF, Gomez-Garcia de la Pedrosa E, Serrador M, González-López JJ, Gonzalez-Sanz M, Martín-Dávila P, Lora-Plaza A, Zaragoza O, Quereda C.

    Cryptococcus neoformans meningoencephalitis, chorioretinitis and recurrent obstructive pneumonia in an immunocompetent migrant from Paraguay.

    JOURNAL OF TRAVEL MEDICINE . 33(5): .

    [doi:10.1093/jtm/taag043]

  • Baquero F, Cantón R, Herencias C, Gama JA, Coque TM.

    Molecular war and peace: the concurrent path to antibiosis and antibiotic resistance.

    Frontiers in Microbiology . 17: 1851874-1851874.

    [doi:10.3389/fmicb.2026.1851874]

  • Yang Q, Tuon FF, Shah S, Kamat S, Mohamed N, Stone GG, Perez KK, Cantón R.

    In vitro activity of aztreonam/avibactam and comparators against Enterobacterales isolates from patients with hospital-acquired pneumonia, ventilator-associated pneumonia, and complicated intra-abdominal infections (ATLAS, 2021-2022).

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY . 81(7): .

    [doi:10.1093/jac/dkag198]

  • Luque-Ramírez M, de Lope Quiñones S, Quintero-Tobar A, Martínez-García MÁ, Insenser M, Nattero-Chávez L, Garriga M, Michael Fernández AC, Escobar-Morreale HF.

    Evidence of early subclinical atherosclerosis in women with exercise-induced hypothalamic amenorrhea.

    Human Reproduction Open . 2026(3): .

    [doi:10.1093/hropen/hoag055]

  • Halperin AV, Gómez-León S, Escudero-Sánchez R, Corbacho-Loarte MD, Suárez-Carantoña C, Saez de la Fuente J, Retamar-Gentil P, Cantón R.

    Structured integration of rapid antimicrobial susceptibility testing and antimicrobial resistance detection into an antimicrobial stewardship programme for bacteraemia.

    JAC-Antimicrobial Resistance . 8(3): .

    [doi:10.1093/jacamr/dlag067]

  • Muñoz Báez P, Illescas López M, de Salazar A, Falces Romero I, Pinto A, Portilla I, Masiá M, Peraire J, Alemán Valls MR, Sanchiz M, Iborra A, Baza B, Aguilera A, Olalla J, Espinosa N, Iribarren JA, Gisbert L, Imaz A, Montero M, Navarro Marcotegui M, Suárez-García I, Riera M, Pérez Elias MJ, Galán JC, García Fraile LJ, Sanz J, Ibarra Ugarte S, Bernal E, Blanco JR, Navarro G, Martínez O, Viciana Ramos MI, Mohamen-Balghata MO, Delgado E, Thompson MM, Moreno C, CoRIS C, Fuentes A, García F.

    Beyond Surveillance Mutations: Long-Term Trends and Clinical Relevance of Transmitted HIV Drug Resistance in Spain (2007-2023).

    Open Forum Infectious Diseases . 13(6): .

    [doi:10.1093/ofid/ofag296]

  • Fuentes-Valverde V, García P, Candela A, Santamarina-Fernández R, Avendaño-Ortiz J, Martínez-Alonso E, Oviaño M, Cantón R, Arenas J, Moscoso M, Bou G.

    Engineering low-endotoxin lipid A in a double auxotroph Pseudomonas aeruginosa to develop safer whole-cell vaccines.

    Frontiers in Cellular and Infection Microbiology . 16: 1840122-1840122. Number of citations: 1

    [doi:10.3389/fcimb.2026.1840122]

  • Bianco G, Bastos P, Gartzonika K, Christaki E, Mavromanolaki VE, Maraki S, Spiliopoulou A, Giormezis N, Lengerova G, Kalchev Y, Budimir A, Bedenic B, Rubic Z, Saskor A, Milanovic K, Licker M, Musuroi C, Juhász E, Kristóf K, Pirs M, Velimirovic I, Berktold M, Krajcíková A, Gryndlerova A, Drevinek P, Sedláková MH, Kolár M, Brzychczy-Wloch M, Olechowska-Jarzab A, Brauncajs M, Bielec F, Seliga-Gasior D, Podsiadly E, Riesbeck K, Andersson HS, Tønjum T, Berild JC, Leegaard TM, Nellemann Rasmussen A, Schønning K, Glöckner S, Rödel J, Posadas-Cantera S, Badr MT, Kintzinger T, Schaumburg F, Thelen P, Hamprecht A, Dudakova A, Jantsch J, Hoffmann K, Kaasch AJ, Jacot D, Greub G, Landi J, Ambretti S, Comini S, Chiatamone Ranieri S, Serretiello E, Franci G, Fasciana T, Schade R, Yusuf E, van Kleef-van Koeveringe S, Vandamme S, Verroken A, Rodriguez-Villalobos H, Strubbe G, Vandendriessche S, Rabeau P, Corvec S, Dubois D, Massip C, Chainier D, Barraud O, Mizrahi A, Bacho C, Bouchiat C, Fatah T, Marchandin H, Jean-Pierre V, Ali S, O'Donnell S, Doyle M, Ramsamaroo Z, Egan C, McNicholas S, Helgason KO, Öngen B, Karapinar BA, Oyardi Ö, Aksu B, Colomina-Rodriguez J, Torres I, Gilarranz Luengo R, Larrosa Escartín MN, Viñado Perez MB, Halperin AV, Cantón R, Seruca M, Santos Mendes V, Volovetska Y, Melo Cristino J, Costa C, Boattini M.

    Minor non-fermenting Gram-negative bacilli in Europe, 2020-2024 (MINOFEu).

    International Journal of Antimicrobial Agents . 67(6): 107772-107772.

    [doi:10.1016/j.ijantimicag.2026.107772]

  • Samuelsen Ø, López-Causapé C, Aarestrup FM, Bortolaia V, Brouwer MSM, Cantón R, Egli A, Grad YH, Hamprecht A, Haussler S, Holt KE, Hopkins KL, Howden BP, Jeannot K, Kahlmeter G, Köser CU, Mathers AJ, Naas T, Pournaras S, Ruppé E, Schön T, Stoesser N, Turnidge J, Werner G, Wright GD, Giske CG, Oliver A.

    The role of whole genome sequencing in antimicrobial susceptibility prediction of bacteria: 2025 update from the European Committee on Antimicrobial Susceptibility Testing Subcommittee.

    CLINICAL MICROBIOLOGY AND INFECTION . 32(7S): . Number of citations: 7

    [doi:10.1016/j.cmi.2026.05.012]

  • Martínez de Aguirre P, Carlos S, Mbikayi S, Burgueño E, Barquín D, Tendobi C, Chiva L, Holguín Á, Reina G.

    Hepatitis B Virus Diagnosis Using Dried Blood Spots in the D.R. Congo: Overcoming Misdiagnosis to Achieve 2030 WHO Targets.

    Medical Sciences . 14(2): .

    [doi:10.3390/medsci14020271]

  • Cantón R, García-Castillo M, Hernández-García M, Sastre-Femenía MÀ, López-Causapé C, Ruiz-Garbajosa P, García Labrador L, Longshaw C, Oliver A.

    Cefiderocol activity against multidrug-resistant isolates from the PERSEUS study: relationship between cefiderocol minimum inhibitory concentration and clinical outcomes.

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY . 81(6): .

    [doi:10.1093/jac/dkag164]

  • Almeida-Santos AC, Tedim AP, Duarte B, Pereira AP, Silva LM, Teixeira J, Castro AP, Roer L, Hammerum AM, Hasman H, Coque TM, Novais C, Freitas AR, Peixe L.

    Twelve years of genomic surveillance of vancomycin-resistant Enterococcus faecium: emergence of linear vanA and bacteriocin-carrying plasmids challenging infection control.

    Genome Medicine . 18(1): . Number of citations: 1

    [doi:10.1186/s13073-026-01656-4]

  • Alberola A, de Salazar A, Fuentes A, Carracedo R, Illescas-López M, Rodríguez Baños MDC, Freyre C, Becerril B, Viciana I, López-Rodríguez I, Montiel N, Domínguez Castaño AM, Luzón-García MP, Ramírez Arellano E, Liébana-Martos C, Franco Álvarez de Luna F, Lozano MDC, Palop B, Sampedro A, Pérez AB, Algarate S, Rojo Alba S, Fraile P, Ocete D, Alcaraz MJ, Rodríguez JC, Hernández-Felices FJ, Martínez O, Domínguez V, Orta N, Gómez D, Cortell C, Camacho J, Sabater S, Iglesias Sánchez LÁ, Martín Y, Vallejo A, Molina L, Aroca M, Castro B, Lara M, Pena MJ, Rodríguez-Fernández A, González Praetorius A, Blas JJ, Beteta A, Gómez C, Rodríguez MJ, Illescas S, Abreu M, García Díez J, Beltrán I, Sandoval Torrientes M, Sáez R, Martín T, Tajada Alegre P, Lorenzo B, García Valero MT, Jiménez Sansegundo I, García-de Cruz S, Garcinuño S, Sáiz MÁ, Muñoz S, Fernández I, Lorenzo Juanes HM, Vidal-Acuña MR, Moldes LM, Calvo N, Trigo M, Gude MJ, Ordóñez P, Cortizo S, Blasco M, Sigcha M, Falces I, Galán JC, Arribi A, Alonso R, Iborra A, Del Amor Espín MJ, Cascales E, Pérez C, Fernández P, Navarro MD, Nuñez ML, Galán Ros J, Gil-Gallardo LJ, Miqueleiz A, Reina G, Elorduy L, Macho M, Gómez C, Liendo P, Salicio Y, Aguilera A, García F.

    Nationwide Implementation of Double Reflex Testing for Hepatitis Delta in Spain: Results From the Retrospective Phase of the Spain-DDR Study.

    ALIMENTARY PHARMACOLOGY & THERAPEUTICS . 63(10): 1390-1397. Number of citations: 3

    [doi:10.1111/apt.70543]

  • Baquero F, Pérez-Cobas AE, Lanza VF.

    Ecogenomic kinetics: wandering bacterial populations stumbling upon niches.

    TRENDS IN MICROBIOLOGY . 34(5): 468-471.

    [doi:10.1016/j.tim.2026.03.009]

  • De Salazar A, Negredo A, Galán JC, Del Peso T, Illescas M, Martínez-García L, Gimeno C, García F, Sánchez-Seco MP.

    Readiness Level of Spanish Labs to Detect Mpox Clade Ib: A Nationwide EQA.

    JOURNAL OF MEDICAL VIROLOGY . 98(5): .

    [doi:10.1002/jmv.70948]

  • Halperin AV, Schwartz F, Christophersen L, Pérez-Del Palacio J, Ponce-Alonso M, Avendaño-Ortiz J, Caballero JD, Cantón R, Moser C, Del Campo R.

    In Vitro Restoration of Colistin Susceptibility by Ivacaftor Synergy with Limited Reproducibility in a Murine Pneumonia Model.

    Antibiotics-Basel . 15(4): .

    [doi:10.3390/antibiotics15040414]

  • Baquero F, Cantón R, Alves Gama J, Rodríguez-Beltrán J.

    Antechokinetics, the kinetics of antimicrobial resistance molecules.

    Frontiers in Pharmacology . 17: 1792355-1792355.

    [doi:10.3389/fphar.2026.1792355]

  • Gil-Gil T, Berryhill BA, Witzany C, Regoes RR, Baquero F, Levin BR.

    The role of the innate immune system in shaping the dynamics of antimicrobial treatment.

    Biorxiv : The Preprint Server For Biology . : .

    [doi:10.64898/2026.04.09.717387]