1. Home
  2. Research
  3. Research Groups
  4. Biology and Evolution of Microorganisms

Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

Search for publications

Only original articles, editorials, guidelines.

  • Martínez de Aguirre P, Carlos S, Mbikayi S, Burgueño E, Barquín D, Tendobi C, Chiva L, Holguín Á, Reina G.

    Hepatitis B Virus Diagnosis Using Dried Blood Spots in the D.R. Congo: Overcoming Misdiagnosis to Achieve 2030 WHO Targets.

    Medical Sciences . 14(2): .

    [doi:10.3390/medsci14020271]

  • Cantón R, García-Castillo M, Hernández-García M, Sastre-Femenía MÀ, López-Causapé C, Ruiz-Garbajosa P, García Labrador L, Longshaw C, Oliver A.

    Cefiderocol activity against multidrug-resistant isolates from the PERSEUS study: relationship between cefiderocol minimum inhibitory concentration and clinical outcomes.

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY . 81(6): .

    [doi:10.1093/jac/dkag164]

  • Almeida-Santos AC, Tedim AP, Duarte B, Pereira AP, Silva LM, Teixeira J, Castro AP, Roer L, Hammerum AM, Hasman H, Coque TM, Novais C, Freitas AR, Peixe L.

    Twelve years of genomic surveillance of vancomycin-resistant Enterococcus faecium: emergence of linear vanA and bacteriocin-carrying plasmids challenging infection control.

    Genome Medicine . 18(1): . Number of citations: 1

    [doi:10.1186/s13073-026-01656-4]

  • Alberola A, de Salazar A, Fuentes A, Carracedo R, Illescas-López M, Rodríguez Baños MDC, Freyre C, Becerril B, Viciana I, López-Rodríguez I, Montiel N, Domínguez Castaño AM, Luzón-García MP, Ramírez Arellano E, Liébana-Martos C, Franco Álvarez de Luna F, Lozano MDC, Palop B, Sampedro A, Pérez AB, Algarate S, Rojo Alba S, Fraile P, Ocete D, Alcaraz MJ, Rodríguez JC, Hernández-Felices FJ, Martínez O, Domínguez V, Orta N, Gómez D, Cortell C, Camacho J, Sabater S, Iglesias Sánchez LÁ, Martín Y, Vallejo A, Molina L, Aroca M, Castro B, Lara M, Pena MJ, Rodríguez-Fernández A, González Praetorius A, Blas JJ, Beteta A, Gómez C, Rodríguez MJ, Illescas S, Abreu M, García Díez J, Beltrán I, Sandoval Torrientes M, Sáez R, Martín T, Tajada Alegre P, Lorenzo B, García Valero MT, Jiménez Sansegundo I, García-de Cruz S, Garcinuño S, Sáiz MÁ, Muñoz S, Fernández I, Lorenzo Juanes HM, Vidal-Acuña MR, Moldes LM, Calvo N, Trigo M, Gude MJ, Ordóñez P, Cortizo S, Blasco M, Sigcha M, Falces I, Galán JC, Arribi A, Alonso R, Iborra A, Del Amor Espín MJ, Cascales E, Pérez C, Fernández P, Navarro MD, Nuñez ML, Galán Ros J, Gil-Gallardo LJ, Miqueleiz A, Reina G, Elorduy L, Macho M, Gómez C, Liendo P, Salicio Y, Aguilera A, García F.

    Nationwide Implementation of Double Reflex Testing for Hepatitis Delta in Spain: Results From the Retrospective Phase of the Spain-DDR Study.

    ALIMENTARY PHARMACOLOGY & THERAPEUTICS . 63(10): 1390-1397. Number of citations: 3

    [doi:10.1111/apt.70543]

  • Baquero F, Pérez-Cobas AE, Lanza VF.

    Ecogenomic kinetics: wandering bacterial populations stumbling upon niches.

    TRENDS IN MICROBIOLOGY . 34(5): 468-471.

    [doi:10.1016/j.tim.2026.03.009]

  • De Salazar A, Negredo A, Galán JC, Del Peso T, Illescas M, Martínez-García L, Gimeno C, García F, Sánchez-Seco MP.

    Readiness Level of Spanish Labs to Detect Mpox Clade Ib: A Nationwide EQA.

    JOURNAL OF MEDICAL VIROLOGY . 98(5): .

    [doi:10.1002/jmv.70948]

  • Halperin AV, Schwartz F, Christophersen L, Pérez-Del Palacio J, Ponce-Alonso M, Avendaño-Ortiz J, Caballero JD, Cantón R, Moser C, Del Campo R.

    In Vitro Restoration of Colistin Susceptibility by Ivacaftor Synergy with Limited Reproducibility in a Murine Pneumonia Model.

    Antibiotics-Basel . 15(4): .

    [doi:10.3390/antibiotics15040414]

  • Baquero F, Cantón R, Alves Gama J, Rodríguez-Beltrán J.

    Antechokinetics, the kinetics of antimicrobial resistance molecules.

    Frontiers in Pharmacology . 17: 1792355-1792355.

    [doi:10.3389/fphar.2026.1792355]

  • Gil-Gil T, Berryhill BA, Witzany C, Regoes RR, Baquero F, Levin BR.

    The role of the innate immune system in shaping the dynamics of antimicrobial treatment.

    Biorxiv : The Preprint Server For Biology . : .

    [doi:10.64898/2026.04.09.717387]

  • Avendaño-Ortiz J, Ventosa-Cubillo J, Rodríguez-Jiménez C, Morales-Pérez D, Muñoz-Hernández R, Pavía-Ruz N, Navarro ML, Holguín Á.

    Perinatal HIV exposure is associated with long-term alterations in immune marker levels in children.

    Journal of Infection and Public Health . 19(4): 103168-103168. Number of citations: 1

    [doi:10.1016/j.jiph.2026.103168]

  • Józwiak G, Pla Verge M, Luraschi-Eggemann A, Mestiri C, McSorley E, Wilson-Owen D, La Fauci S, García-Castillo M, Delarze E, Fromm K, Munch L, Vogel C, Balasopoulos D, Cathomen G, Reiter S, Swiatkowski M, Totu R, Häussler S, Tenson T, Pagliara S, Cantón R, Greub G, Lisby G, Mullen W, Lockhart D, Cichocka D, Sturm A.

    Nanomotion-enabled ultra-rapid antibiotic susceptibility testing with magnetic bead-based pathogen enrichment for accelerated sepsis diagnostics.

    Scientific Reports . 16(1): .

    [doi:10.1038/s41598-026-44519-z]

  • Fernández-de-Bobadilla MD, Pérez-Cobas AE, Andremont A, Martínez JL, Baquero F, Lanza VF, Coque TM.

    The antimicrobial gut resistome of the Wayampi reveals a shared background of antibiotic and metal resistance genes with industrialized populations, underscoring the "robust-yet-fragile" architecture of human gut microbiomes.

    Microbiome . 14(1): .

    [doi:10.1186/s40168-026-02345-5]

  • Fluit AC, Bayjanov JR, Aguilar MD, Cantón R, Gilpin DF, Tunney MM, Ekkelenkamp MB.

    Qualitative analysis of genomic mutations and antibiotic susceptibility testing of Pseudomonas aeruginosa isolates from chronic lung infections.

    PLoS One . 21(3): .

    [doi:10.1371/journal.pone.0341613]

  • Romero-Rivera M, Fernández-de-Bobadilla MD, Beltrán M, del Campo R, Avendaño-Ortiz J, Herencias C.

    Genome assembly and functional predation analysis of novel Bdellovibrio isolates from human gut microbiota.

    Frontiers in Microbiology . 17: 1752098-1752098. Number of citations: 2

    [doi:10.3389/fmicb.2026.1752098]

  • Pérez-Martínez L, Romero L, Palacios E, Barbero R, Moreno-Blanco A, del Campo R, Blanco JR.

    Oral microbiota in patients with long COVID: A pilot study.

    Enfermedades Infecciosas Y Microbiologia Clinica (english Ed.) . 44(2): 503072-503072.

    [doi:10.1016/j.eimce.2026.503072]

  • Astiz N, Martínez de Aguirre P, Carlos S, Mbikayi S, Barquín D, Burgueño E, Holguín Á, Reina G.

    Long-term stability of dried blood spot samples for HIV diagnosis in adults from Kinshasa (Democratic Republic of Congo).

    JOURNAL OF CLINICAL VIROLOGY . 182: 105910-105910.

    [doi:10.1016/j.jcv.2025.105910]

  • Ramiro-Martínez P, Quinto I, Jaraba-Soto L, Lanza VF, Herencias-Rodríguez C, González Casanova A, Peña-Miller R, Rodríguez-Beltrán J.

    Plasmid mutation rates scale with copy number.

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA . 123(4): . Number of citations: 1

    [doi:10.1073/pnas.2526088123]

  • Cano-Pérez M, Caballero Pérez JD, Gómez García de la Pedrosa E, Gómez-López A.

    Biofilm Formation in Aspergillus fumigatus: A Comparative Study of Strains from Different Origins.

    Microorganisms . 14(2): . Number of citations: 2

    [doi:10.3390/microorganisms14020272]