1. Home
  2. Research
  3. Research Groups
  4. Biology and Evolution of Microorganisms

Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

Search for publications

Only original articles, editorials, guidelines.

  • Pastor-Vivero MD, Costa I Colomer J, Martín de Vicente C, Vicente-Santamaria S, Garcia Romero R, González Jiménez D, Luna Paredes C.

    Advances in the treatment of cystic fibrosis: CFTR modulators.

    Anales De Pediatria . 102(5): 503857-503857.

    [doi:10.1016/j.anpede.2025.503857]

  • Rodriguez-Temporal D, Adrados D, Alastruey-Izquierdo A, Alkorta M, Candela A, Canut A, Castro C, Cilla CG, de Dios Caballero J, Ercibengoa M, Fernández M, Fradejas I, Fraile O, Goyanes MJ, Gutiérrez A, López JI, López C, López-Calleja AI, López-Medrano R, Muñoz P, Ortega AM, Oviaño M, Peman J, Rodríguez-Mayo M, Ruiz A, Tristancho A, Rodríguez-Sánchez B.

    Current Performance of MALDI-TOF Mass Spectrometry Databases for the Identification of Dermatophyte Species

    JOURNAL OF FUNGI . 11(5): . Number of citations: 3

    [doi:10.3390/jof11050356]

  • García Romero R, López Cárdenes C, Crehuá Gaudiza E, Álvarez Beltrán M, Murray Hurtado M, Tutau Gómez C, Loverdos Eseverri I, Torcuato Rubio E, García Volpe C, Salcedo Lobato E, Medina Martínez M, Martin Fernández C, Moreno Álvarez A, Reyes Domínguez A, González Jiménez D.

    Improvement of intestinal inflammation after treatment with CFTR modulators in cystic fibrosis patients.

    Anales De Pediatria . 102(5): 503836-503836.

    [doi:10.1016/j.anpede.2025.503836]

  • Crehuá-Gaudiza E, Vicente Santamaría S, Álvarez Beltrán M, Martín Fernández C, Tutau Gómez C, Loverdos Eseverri I, García Romero R, Torcuato Rubio E, Del Brío Castillo R, Garriga García M, Gascón Galindo C, Gutiérrez Martínez JR, Castro Millán AM, Sierra San Nicolás S, Ortiz Pérez P, García Volpe C, Salcedo Lobato E, De La Mano Hernández A, Fernández González SM, Reyes Domínguez A, Peña-Quintana L, González Jiménez D.

    Effect of cystic fibrosis modulator therapies on serum levels of fat-soluble vitamins.

    Jpgn Reports . 6(2): 146-152. Number of citations: 2

    [doi:10.1002/jpr3.70007]

  • Vicente-Santamaría S, Torres-Guerrero ME, García-González M, Tabares-González A, Gascón-Galindo C, López-Cárdenes CM, Blitz-Castro E, Morales-Tirado A, Mota Goitia MI, Gutiérrez Martínez JR, Tutau Gómez C, García Romero R, Salcedo Lobato E, Peña Quintana L, Reyes Domínguez A, Torcuato Rubio E, Ortiz Pérez P, Fernández-Lorenzo AE, Moreno Álvarez A, Boga AS, Romero Rey H, Álvarez Beltrán M, Masip Simo E, González Jiménez D.

    Assessment of cystic fibrosis related liver disease in a pediatric cohort

    GASTROENTEROLOGIA Y HEPATOLOGIA . 48(5): 502321-502321. Number of citations: 1

    [doi:10.1016/j.gastrohep.2024.502321]

  • De La Villa S, Escrihuela-Vidal F, Fernández-Hidalgo N, Escudero-Sánchez R, Cabezón I, Boix-Palop L, Díaz-Pollán B, Goikoetxea AJ, García-País MJ, Pérez-Rodríguez MT, Crespo Á, Buzón-Martín L, Sanz-Peláez O, Ramos-Merino L, Silvante F, Muñoz P.

    Ceftaroline for bloodstream infections caused by methicillin-resistant Staphylococcus aureus: a multicentre retrospective cohort study

    CLINICAL MICROBIOLOGY AND INFECTION . 31(5): 793-801. Number of citations: 6

    [doi:10.1016/j.cmi.2024.11.022]

  • de Córdoba-Ansón PF, Linares-Ambohades I, Baquero F, Coque TM, Pérez-Cobas AE.

    The Respiratory Tract Microbiome and Human Health

    Microbial Biotechnology . 18(5): . Number of citations: 3

    [doi:10.1111/1751-7915.70147]

  • Arredondo-Alonso S, Pöntinen AK, Gama JA, Gladstone RA, Harms K, Tonkin-Hill G, Thorpe HA, Simonsen GS, Samuelsen Ø, Johnsen PJ, Corander J.

    Plasmid-driven strategies for clone success in Escherichia coli

    NATURE COMMUNICATIONS . 16(1): 2921-2921. Number of citations: 10

    [doi:10.1038/s41467-025-57940-1]

  • Becerra-Aparicio F, Gómez-Zorrilla S, Hernández-García M, Xanthopoulou K, Gijón D, Siverio A, Berbel D, Cercenado E, Rivera A, De Malet A, Xercavins M, Ruiz De Gopegui E, Canoura-Fernández L, Martínez JA, Seral C, Del Pozo JL, Cotarelo M, Ponz R, Higgins PG, Durán-Jordà X, Cantón R, Oliver A, Horcajada JP, Ruiz-Garbajosa P.

    Whole Genome Sequencing Analysis of Klebsiella pneumoniae Isolates from Health Care-Associated Bacteremia of Urinary Origin in Spain: Findings from the Multicenter ITUBRAS-2 Cohort Study

    Open forum infectious diseases . 12(4): .

    [doi:10.1093/ofid/ofaf164]

  • Ismail AS, Berryhill BA, Gil-Gil T, Manuel JA, Smith AP, Baquero F, Levin BR.

    The tradeoffs between persistence and mutation rates at sub-inhibitory antibiotic concentrations in Staphylococcus aureus

    Microbiology spectrum . 13(4): .

    [doi:10.1128/spectrum.02479-24]

  • Serrano-Tomás MI, Cabello M, Moreno-Nuñez P, Sanz JC, Cantón R, Sánchez-Díaz AM.

    Invasive pneumococcal disease in a tertiary hospital in Madrid: are we using pneumococcal vaccine correctly?

    Enfermedades Infecciosas Y Microbiologia Clinica (english Ed.) . 43(4): 210-214.

    [doi:10.1016/j.eimce.2025.03.009]

  • Peñalva G, Cantón R, Pérez-Rodríguez MT, González-López JJ, Rodríguez-Baño J, Barrio-Tofiño ED, Kirkegaard-Biosca C, Sánchez-Romero I, Gutiérrez-Villanueva A, Marrodán-Ciordia T, Guerra-Laso JM, Rosario-Quintana CD, Suárez-Hormiga L, Cámara J, Puig-Asensio M, Heredero E, Sepúlveda MA, Rodríguez-Díaz JC, Merino E, Cercenado E, Villa S, Siller M, Arnaiz F, Seral C, Lepe JA, Cisneros JM, Paño-Pardo JR.

    Burden of bacterial antimicrobial resistance among hospitalised patients in Spain: findings from three nationwide prospective studies

    LANCET REGIONAL HEALTH-EUROPE . 51: 101220-101220. Number of citations: 11

    [doi:10.1016/j.lanepe.2025.101220]

  • Vicente-Santamaría S, Tabares-González A, Gascón-Galindo C, Tutau-Gómez C, Álvarez-Beltrán M, Muñoz-Codoceo RA, Rubio-Murillo M, De-Los-Santos M, Salcedo-Lobato E, Masip-Simó E, García-Romero R, Fernández-Lorenzo AE, Moreno-Álvarez A, Serrano-Nieto J, Hierro-Llanillo L, Loverdos-Eseverri I, Crehuá-Gaudiza E, Juste-Ruiz M, Blitz-Castro E, Morales-Tirado A, López-Cárdenes CM, Bousoño-García C, González-Jiménez D.

    Current situation of pediatric cystic fibrosis-related liver disease: results of a Spanish nationwide study.

    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY . 37(4): 505-509.

    [doi:10.1097/MEG.0000000000002917]

  • Ruedas-López A, Tato M, Lerma L, Esteban J, Muñoz-Egea MC, Toro C, Domingo D, Prados-Rosales R, López-Roa P.

    Infection model of THP-1 cells, growth dynamics, and antimicrobial susceptibility of clinical Mycobacterium abscessus isolates from cystic fibrosis patients: Results from a multicentre study

    Plos One . 20(3): .

    [doi:10.1371/journal.pone.0319710]

  • Monge-Maillo B, Roger-Zapata D, Dronda F, Carrillo E, Moreno J, Corbacho-Loarte MD, Gayoso Cantero D, Martín O, Chamorro-Tojeiro S, Perez-Molina JA, Norman F, González-Sanz M, López-Vélez R.

    Case Report: Long-Term Follow-Up of Visceral Leishmaniasis and HIV Coinfected Patients Without Relapse: Lymphoproliferative Response After Stimulation with Soluble Leishmania Antigen

    Microorganisms . 13(3): .

    [doi:10.3390/microorganisms13030686]

  • Meyer R, Arpe L, Kansu A, Kelly V, Lindley K, O'Meara M, Del Carmen Rivero M, van Zundert S, Vicente-Santamaría S, Žaja O, Oliveros E, Olivier L, Joosten K.

    Gastrointestinal changes in paediatric malnutrition that may impact on nutrition choice

    Frontiers in Pediatrics . 13: 1523613-1523613. Number of citations: 2

    [doi:10.3389/fped.2025.1523613]

  • Bhowmick T, Canton R, Pea F, Quevedo J, Santerre Henriksen A, Timsit JF, Kaye KS.

    Cefepime-enmetazobactam: first approved cefepime-ß- lactamase inhibitor combination for multi-drug resistant Enterobacterales

    Future Microbiology . 20(4): 277-286. Number of citations: 11

    [doi:10.1080/17460913.2025.2468112]

  • Blasco L, Ibarguren-Quiles C, López-Causape C, Armán L, Barrio-Pujante A, Bleriot I, Pacios O, Fernández-García L, Ortiz-Cartagena C, Cant?n R, Oliver A, Tomás M.

    Study of the probability of resistance to phage infection in a collection of clinical isolates of Pseudomonas aeruginosa in relation to the presence of Pf phages

    Microbiology spectrum . 13(3): . Number of citations: 1

    [doi:10.1128/spectrum.03010-24]