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Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

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Only original articles, editorials, guidelines.

  • Eckmann C, Akova M, Antonelli M, Bassetti M, Cantón R, Dryden M, Falcone M, Kanj SS, Kiertiburanakul S, Gilchrist M, Montravers P, Paterson DL, Senneville E, Soriano A, Timsit JF, Villegas MV, Viale P.

    Responsible use of new antibiotics for critically ill patients suffering from infections due to carbapenem-resistant organisms-a narrative review for an enablement strategy.

    JAC-Antimicrobial Resistance . 8(6): .

    [doi:10.1093/jacamr/dlag226]

  • Rodríguez-Molino P, Rodríguez Galet A, Falces-Romero I, Alcolea S, Méndez-Echevarría A, Del Rosal T, Cámara C, Grasa C, Calvo C, Martínez Balaguer M, Holguín Á, Sainz T.

    Vaccine Response Assessment in Children Using Dried Blood Spots: The DRIVE Study.

    JOURNAL OF INFECTIOUS DISEASES . 234(4): .

    [doi:10.1093/infdis/jiag274]

  • Simaluiza-Masabanda RJ, Pérez-Viso B, Cambisaca A, Chocho JL, Romero-Saritama JM, Ochoa S, Ullauri C, Lizalde A, Uchuari J, Jumbo C, Fernández H, Cantón R.

    Phenotypic and Molecular Characterization of ESBL-Producing Enterobacterales from Intestinal Colonization in Loja, Ecuador.

    Antibiotics-Basel . 15(10): .

    [doi:10.3390/antibiotics15100998]

  • Baquero F, Coque TM, Rodríguez-Beltrán J, Aracil-Gisbert S, Pérez-Cobas AE.

    Ecological Kinetics and Evolutionary Dynamics of Antibiotic Resistance in Complex Environments.

    Annual Review of Microbiology . 80(1): 263-285.

    [doi:10.1146/annurev-micro-042524-080452]

  • Illescas-López M, Muñoz P, de Salazar A, Delgado R, Iborra A, Galán JC, Carracedo R, Sigcha M, López-Causape C, Fuentes A, Aguilera A, Marco-Sánchez C, García F.

    HIV-1 APOBEC-context mutations detected by next-generation sequencing in plasma: implications for drug resistance interpretation.

    JOURNAL OF INFECTIOUS DISEASES . 234(3): .

    [doi:10.1093/infdis/jiag277]

  • García-García S, Rodríguez-Grande J, Siller-Ruíz M, Arjona-Torres C, Viedma E, Díez-Aguilar M, Hernández-García M, Fernández-Domínguez J, Cercenado E, Lázaro-Perona F, Oteo-Iglesias J, Ruiz-Garbajosa P, Cantón R, Valcárcel-Fraile N, Gallego L, Roiz-Mesones MP, Calvo-Montes J, Martínez-Martínez L, Ocampo-Sosa A, García-Fernández S.

    Evaluation of carbapenem inactivation method-based phenotypic assays for the detection of GES-type carbapenemases in Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii.

    JOURNAL OF CLINICAL MICROBIOLOGY . 64(9): .

    [doi:10.1128/jcm.00737-26]

  • Toledo D, Soldevila N, Galan JC, Godoy P, Morales-Suarez-Varela M, Rodriguez-Suárez M, Grau M, Fernández-Villa T, Morillo A, Navarro G, Chamorro J, Domínguez A.

    Influenza Vaccination Effectiveness in Preventing Hospitalization of Adults With Underlying Medical Conditions: A Multicentre Case-Control Study.

    Influenza and Other Respiratory Viruses . 20(9): .

    [doi:10.1111/irv.70304]

  • Khalid A, Gettins L, Scullion L, Liu X, Lin Wei LL, Masai AN, Guerin PJ, Allel K, Hemelaar J.

    Global and regional molecular epidemiology of HIV-1 during 1990-2024: systematic review, global survey, and analysis of prevalence.

    LANCET INFECTIOUS DISEASES . 26(9): 939-955.

    [doi:10.1016/S1473-3099(26)00142-8]

  • Hernández-García M, Pérez-Viso B, Nieto-Torres M, García-Castillo M, Michelena M, Martínez-Martínez L, Baquero F, Ruiz-Garbajosa P, Cantón R.

    Addressing therapeutic options for KPC-3-producing ST307-Klebsiella pneumoniae: insights from in vitro evolution and mutant prevention strategies.

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY . 70(8): .

    [doi:10.1128/aac.00488-26]

  • Cano-Fernandez M, Barrado L, Bermudez-Marvalc H, Cabrera-Pineda M, Diaz-De-La-Torre I, Domingo D, Hernandez S, Garcia-Martinez J, Lopez-Roa P, Loras-Gallego C, Muñoz-Egea M-C, Ruiz-Serrano M-J, Simon M, Tato M, Toro C, Valverde-Canovas JF, Viñuela-Gonzalez L, Esteban J, Salar-Vidal L.

    Evaluation of clinical usefulness of a commercial multiplex PCR for diagnosing mycobacterial infections: a multicenter study.

    Microbiology Spectrum . 14(8): .

    [doi:10.1128/spectrum.00175-26]

  • Chaves-Blanco L, Illescas-López M, Fuentes A, Carracedo R, Delgado-Iribarren A, Vázquez Blanquiño A, Blázquez AM, Sáez R, Miqueleiz A, Vidal MLR, Tosco T, Gómez C, Moldes L, Calvo N, Pérez Rodríguez L, Trigo M, Ocete MD, Alcaraz MJ, Iborra MA, García J, Blas JJ, Vallejo AM, Alberola Romano A, Illescas S, Rodriguez JC, Alonso R, Cámara M, Navarro MD, Núñez ML, Del Amor Espín MJ, Beteta A, Cascales E, Soria LM, Gacinuño S, Sandoval M, Cortizo S, Ordóñez P, Liendo P, Pérez-Ruiz M, Álvarez Argüelles M, García F, Rodriguez I, Gómez C, Elorduy L, Hernández Febles M, González-Praetorius A, Liébana C, Molina ML, Salicio Y, Macho M, Becerril B, Franco Álvarez F, Falces I, Algarate S, Gude MJ, Pablo D, Lara MM, Montiel N, Freyre C, Galán JC, Pérez AB, Lorenzo B, Fraile P, Sánchez-Yebra W, Viciana I, Sampedro A, Lozano MDC, Domínguez Castaño A, Ramírez E, Beltrán I, Martín T, Puerta A, Tajada P, Panés P, Martín A, Hurtado JC, López Braos J, Arjona F, Miró E, Ruiz M, Ramírez M, Gil Fortuño M, González Pellicer R, Acedo JM, Anel Pedroche J, Infante Urrios A, Domínguez V, Arán Tohá G, Martínez Macías O, Orta Mira N, Torres Sopena L, Cantudo P, Hernández MA, Arroyo Serrano T, Rando A, Garrido M, Fernández G, de Salazar A, Aguilera A, García F.

    Implementation of quantitative HBsAg testing in clinical microbiology laboratories in Spain: Results from a national GEHEP-SEIMC survey.

    Enfermedades Infecciosas Y Microbiologia Clinica (english Ed.) . 44(7): 503215-503215.

    [doi:10.1016/j.eimce.2026.503215]

  • Dezza FC, Pulido LB, Borreguero IB, Pérez FD, Jiménez VP, de la Rosa Riestra S, Bravo-Ferrer JM, Palacios-Baena ZR, Zuñiga MÁL, Cobo F, Gómez-Junyent J, Horcajada JP, Merino E, Parra M, López-Contreras J, Rivera A, Regueiro DS, Garcia MP, Cardenas SL, Sánchez MCG, Camacho IP, Ramos SMM, Jiménez EL, García AIA, Pérez-Rodríguez MT, Sousa A, Ruiz MS, de Las Revillas Almajano FA, Pérez LG, Agirre JG, Cano Á, Martínez-Marcos FJ, País MJG, Sánchez RE, de la Villa S, Ara JRY, Esteban-Moreno MÁ, Ruiz-Sancho A, Aragón MP, Fernández JA, Blandino AMB, Vilchez-Rueda HH, Álvarez-Marín R, Palacios AR, Vázquez EG, Álvarez EN, Rosso-Fernández C, Gutiérrez-Gutiérrez B, Pascual Á, López-Cerero L, Rodríguez-Baño J.

    Temocillin versus carbapenems for bacteraemia due to third-generation cephalosporin-resistant Enterobacterales in Spain (ASTARTÉ): a multicentre, phase 3, open-label, non-inferiority, randomised clinical trial.

    LANCET . 408(10553): 430-439.

    [doi:10.1016/S0140-6736(26)00760-9]

  • Boattini M, Bastos P, Gartzonika K, Christaki E, Mavromanolaki VE, Maraki S, Spiliopoulou A, Giormezis N, Lengerova G, Kalchev Y, Budimir A, Bedenic B, Rubic Z, Saskor A, Milanovic K, Licker M, Musuroi C, Juhász E, Kristóf K, Pirs M, Velimirovic I, Berktold M, Krajcíková A, Gryndlerova A, Drevinek P, Sedláková MH, Kolár M, Brzychczy-Wloch M, Olechowska-Jarzab A, Brauncajs M, Bielec F, Seliga-Gasior D, Podsiadly E, Riesbeck K, Andersson HS, Tønjum T, Berild JC, Leegaard TM, Rasmussen AN, Schønning K, Glöckner S, Rödel J, Posadas-Cantera S, Badr MT, Kintzinger T, Schaumburg F, Thelen P, Hamprecht A, Dudakova A, Jantsch J, Hoffmann K, Kaasch AJ, Jacot D, Greub G, Landi J, Ambretti S, Comini S, Ranieri SC, Serretiello E, Franci G, Fasciana T, Schade R, Yusuf E, Koeveringe SVKV, Vandamme S, Verroken A, Rodriguez-Villalobos H, Strubbe G, Vandendriessche S, Rabeau P, Corvec S, Dubois D, Floch P, Chainier D, Barraud O, Mizrahi A, Bacho C, Bouchiat C, Fatah T, Marchandin H, Jean-Pierre V, Ali S, Donnell SO, Doyle M, Ramsamaroo Z, Egan C, McNicholas S, Helgason KO, Öngen B, Karapinar BA, Oyardi Ö, Aksu B, Colomina-Rodriguez J, Torres I, Luengo RG, Escartín MNL, Perez MBV, Halperin AV, Cantón R, Seruca M, Mendes VS, Volovetska Y, Cristino JM, Costa C, Bianco G.

    Epidemiology and antimicrobial resistance patterns of Aeromonas species in Europe, 2020-2024 (AEuROMONAS).

    DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE . 115(4): 117384-117384.

    [doi:10.1016/j.diagmicrobio.2026.117384]

  • Casado JL, Vizcarra P, Izuzquiza I, Rodriguez-Dominguez MJ, Romero-Hernandez B, Moreno A, Vallejo A.

    Long-Term Serologic Outcomes Following Treatment of Syphilis in People With HIV: A Prospective Cohort Study.

    CLINICAL INFECTIOUS DISEASES . 83(1): 174-182.

    [doi:10.1093/cid/ciag193]

  • Pérez-Viso B, Hernández-García M, Fernández-de-Bobadilla MD, Baquero F, Aracil-Gisbert S, Coque TM, Del Campo R, Cantón R.

    The current discordance on Serratia spp. taxonomical diagnosis using proteomics or genomic tools.

    BMC MICROBIOLOGY . 26(1): .

    [doi:10.1186/s12866-026-05406-9]

  • Cantón R, Lim AN, Cortés V, Díaz-Regañón J.

    Uncomplicated Urinary Tract Infections: From an Invisible Impact to a Visible Change in Complex Care.

    CLINICAL INFECTIOUS DISEASES . 82(6): .

    [doi:10.1093/cid/ciaf705]

  • Nguyen NM, Weber A, Xavier BB, Rodríguez-Ruiz JP, Kola A, Behnke M, Geffers C, Goossens H, Harbarth S, Bonten M, Canton R, Gastmeier P, Glupczynski Y, Maechler F, Malhotra-Kumar S, On Behalf Of The R-Gnosis Wp Starcs Wp And Mistar Wp Study Groups.

    Genomic surveillance reveals long-term endemicity and outbreak potential of Klebsiella pneumoniae sequence type 48 in a German hospital and its global context.

    Microbial Genomics . 12(7): .

    [doi:10.1099/mgen.0.001707]

  • Paniagua-García M, Bernal-Aznar JM, Gkrania-Klotsas E, Soper I, Montoya MLP, Reynaga EA, Valiente A, Domínguez-Jiménez MC, Lombardi A, Navarro M, Cobo F, Freire M, Halperin AV, Alsina L, Garzaro M, Christ SCC, Laporte-Amargos J, de Gopegui-Bordes ER, Martínez-Martínez L, Oliveira MS, García-López V, Martinez-Marcos FJ, Cendejas E, Del Arco-Jiménez A, Chávez-Caballero M, López-Cardenas S, Rodríguez-Iglesias MA, Alonso CA, Giannella M, Gimeno-Gascón A, Sánchez-Suero P, Jiménez-Jorge S, Pachón J, Pachón-Ibáñez ME, Cordero E.

    Campylobacter spp Bloodstream Infections in Immunocompetent vs Immunodeficient Patients: A Multinational Cohort Study (2009-2024).

    Open Forum Infectious Diseases . 13(7): .

    [doi:10.1093/ofid/ofag380]