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Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

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Only original articles, editorials, guidelines.

  • Berendonk TU, Manaia CM, Merlin C, Fatta-Kassinos D, Cytryn E, Walsh F, Bürgmann H, Sørum H, Norström M, Pons MN, Kreuzinger N, Huovinen P, Stefani S, Schwartz T, Kisand V, Baquero F, Martinez JL.

    Tackling antibiotic resistance: the environmental framework.

    NATURE REVIEWS MICROBIOLOGY . 13(5): 310-317. Number of citations: 1036

    [doi:10.1038/nrmicro3439]

  • Mikalsen T, Pedersen T, Willems R, Coque TM, Werner G, Sadowy E, van Schaik W, Jensen LB, Sundsfjord A, Hegstad K.

    Investigating the mobilome in clinically important lineages of Enterococcus faecium and Enterococcus faecalis

    Bmc Genomics . 16: 282-282. Number of citations: 46

    [doi:10.1186/s12864-015-1407-6]

  • Miao J, Ling AV, Manthena PV, Gearing ME, Graham MJ, Crooke RM, Croce KJ, Esquejo RM, Clish CB, Morbid Obesity Study Group, Vicent D, Biddinger SB.

    Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis

    NATURE COMMUNICATIONS . 6: 6498-6498. Number of citations: 217

    [doi:10.1038/ncomms7498]

  • Luis Justicia, Jose, Sole, Amparo, Quintana-Gallego, Esther, Gartner, Silvia, de Gracia, Javier, Prados, Concepcion, Maiz, Luis.

    Management of pulmonary exacerbations in cystic fibrosis: still an unmet medical need in clinical practice

    EXPERT REVIEW OF RESPIRATORY MEDICINE . 9(2): 183-194. Number of citations: 10

    [doi:10.1586/17476348.2015.1016504]

  • Correa A, Del Campo R, Perenguez M, Blanco VM, Rodríguez-Baños M, Perez F, Maya JJ, Rojas L, Cantón R, Arias CA, Villegas MV.

    Dissemination of High-Risk Clones of Extensively Drug-Resistant Pseudomonas aeruginosa in Colombia

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY . 59(4): 2421-2425. Number of citations: 42

    [doi:10.1128/AAC.03926-14]

  • Rhee SY, Blanco JL, Jordan MR, Taylor J, Lemey P, Varghese V, Hamers RL, Bertagnolio S, Rinke de Wit TF, Aghokeng AF, Albert J, Avi R, Avila-Rios S, Bessong PO, Brooks JI, Boucher CA, Brumme ZL, Busch MP, Bussmann H, Chaix ML, Chin BS, D'Aquin TT, De Gascun CF, Derache A, Descamps D, Deshpande AK, Djoko CF, Eshleman SH, Fleury H, Frange P, Fujisaki S, Harrigan PR, Hattori J, Holguin A, Hunt GM, Ichimura H, Kaleebu P, Katzenstein D, Kiertiburanakul S, Kim JH, Kim SS, Li Y, Lutsar I, Morris L, Ndembi N, Ng KP, Paranjape RS, Peeters M, Poljak M, Price MA, Ragonnet-Cronin ML, Reyes-Terán G, Rolland M, Sirivichayakul S, Smith DM, Soares MA, Soriano VV, Ssemwanga D, Stanojevic M, Stefani MA, Sugiura W, Sungkanuparph S, Tanuri A, Tee KK, Truong HH, van de Vijver DA, Vidal N, Yang C, Yang R, Yebra G, Ioannidis JP, Vandamme AM, Shafer RW.

    Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient- and sequence-level meta-analysis.

    PLOS MEDICINE . 12(4): . Number of citations: 170

    [doi:10.1371/journal.pmed.1001810]

  • Romero-Hernández B, Tedim AP, Sánchez-Herrero JF, Librado P, Rozas J, Muñoz G, Baquero F, Cantón R, Del Campo R.

    Streptococcus gallolyticus subsp. gallolyticus from human and animal origins: genetic diversity, antimicrobial susceptibility, and characterization of a vancomycin-resistant calf isolate carrying a vanA-Tn1546-like element.

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY . 59(4): 2006-2015. Number of citations: 13

    [doi:10.1128/AAC.04083-14]

  • Lanza VF, Tedim AP, Martínez JL, Baquero F, Coque TM.

    The Plasmidome of Firmicutes: Impact on the Emergence and the Spread of Resistance to Antimicrobials.

    Microbiology spectrum . 3(2): . Number of citations: 59

    [doi:10.1128/microbiolspec.PLAS-0039-2014]

  • García-Fernández S, Morosini MI, Marco F, Gijón D, Vergara A, Vila J, Ruiz-Garbajosa P, Cantón R.

    Evaluation of the eazyplex (R) SuperBug CRE system for rapid detection of carbapenemases and ESBLs in clinical Enterobacteriaceae isolates recovered at two Spanish hospitals

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY . 70(4): 1047-1050. Number of citations: 41

    [doi:10.1093/jac/dku476]

  • Curiao T, Marchi E, Viti C, Oggioni MR, Baquero F, Martinez JL, Coque TM.

    Polymorphic variation in susceptibility and metabolism of triclosan-resistant mutants of Escherichia coli and Klebsiella pneumoniae clinical strains obtained after exposure to biocides and antibiotics.

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY . 59(6): 3413-3423. Number of citations: 24

    [doi:10.1128/AAC.00187-15]

  • Zischka M, Künne CT, Blom J, Wobser D, Sak?nç T, Schmidt-Hohagen K, Dabrowski PW, Nitsche A, Hübner J, Hain T, Chakraborty T, Linke B, Goesmann A, Voget S, Daniel R, Schomburg D, Hauck R, Hafez HM, Tielen P, Jahn D, Solheim M, Sadowy E, Larsen J, Jensen LB, Ruiz-Garbajosa P, Quiñones Pérez D, Mikalsen T, Bender J, Steglich M, Nübel U, Witte W, Werner G.

    Comprehensive molecular, genomic and phenotypic analysis of a major clone of Enterococcus faecalis MLST ST40

    Bmc Genomics . 16: 175-175. Number of citations: 22

    [doi:10.1186/s12864-015-1367-x]

  • Cantón R, Máiz L, Escribano A, Olveira C, Oliver A, Asensio O, Gartner S, Roma E, Quintana-Gallego E, Salcedo A, Girón R, Barrio MI, Pastor MD, Prados C, Martínez-Martínez MT, Barberán J, Castón JJ, Martínez-Martínez L, Poveda JL, Vázquez C, de Gracia J, Solé A.

    Spanish Consensus on the Prevention and Treatment of Pseudomonas aeruginosa Bronchial Infections in Cystic Fibrosis Patients

    ARCHIVOS DE BRONCONEUMOLOGIA . 51(3): 140-150. Number of citations: 29

    [doi:10.1016/j.arbres.2014.09.021]

  • Valverde A, Turrientes MC, Norman F, San Martín E, Moreno L, Pérez-Molina JA, López-Vélez R, Cantón R.

    CTX-M-15-non-ST131 Escherichia coli isolates are mainly responsible of faecal carriage with ESBL-producing Enterobacteriaceae in travellers, immigrants and those visiting friends and relatives

    CLINICAL MICROBIOLOGY AND INFECTION . 21(3): . Number of citations: 24

    [doi:10.1016/j.cmi.2014.09.021]

  • Pérez-Losada M, Arenas M, Galán JC, Palero F, González-Candelas F.

    Recombination in viruses: Mechanisms, methods of study, and evolutionary consequences

    INFECTION GENETICS AND EVOLUTION . 30: 296-307. Number of citations: 135

    [doi:10.1016/j.meegid.2014.12.022]

  • López-Collazo E, Jurado T, de Dios Caballero J, Pérez-Vázquez M, Vindel A, Hernández-Jiménez E, Tamames J, Cubillos-Zapata C, Manrique M, Tobes R, Máiz L, Cantón R, Baquero F, Del Campo R.

    In vivo attenuation and genetic evolution of a ST247-SCCmecI MRSA clone after 13 years of pathogenic bronchopulmonary colonization in a patient with cystic fibrosis: implications of the innate immune response.

    MUCOSAL IMMUNOLOGY . 8(2): 362-371. Number of citations: 12

    [doi:10.1038/mi.2014.73]

  • Tedim AP, Ruiz-Garbajosa P, Corander J, Rodríguez CM, Cantón R, Willems RJ, Baquero F, Coque TM.

    Population biology of intestinal enterococcus isolates from hospitalized and nonhospitalized individuals in different age groups.

    APPLIED AND ENVIRONMENTAL MICROBIOLOGY . 81(5): 1820-1831. Number of citations: 55

    [doi:10.1128/AEM.03661-14]

  • Baquero F, Lanza VF, Cantón R, Coque TM.

    Public health evolutionary biology of antimicrobial resistance: priorities for intervention.

    EVOLUTIONARY APPLICATIONS . 8(3): 223-239. Number of citations: 37

    [doi:10.1111/eva.12235]

  • Shaw E, Benito N, Rodríguez-Baño J, Padilla B, Pintado V, Calbo E, Pallarés MA, Gozalo M, Ruiz-Garbajosa P, Horcajada JP.

    Risk factors for severe sepsis in community-onset bacteraemic urinary tract infection: Impact of antimicrobial resistance in a large hospitalised cohort

    JOURNAL OF INFECTION . 70(3): 247-254. Number of citations: 13

    [doi:10.1016/j.jinf.2014.09.011]