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Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

Search for publications

Only original articles, editorials, guidelines.

  • Villa L, Capone A, Fortini D, Dolejska M, Rodríguez I, Taglietti F, De Paolis P, Petrosillo N, Carattoli A.

    Reversion to susceptibility of a carbapenem-resistant clinical isolate of Klebsiella pneumoniae producing KPC-3

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY . 68(11): 2482-2486. Number of citations: 37

    [doi:10.1093/jac/dkt235]

  • Delgado-Rodríguez M, Castilla J, Godoy P, Martín V, Soldevila N, Alonso J, Astray J, Baricot M, Galán JC, Castro A, Gónzález-Candelas F, Mayoral JM, Quintana JM, Pumarola T, Tamames S, Sáez M, Domínguez A, CIBERESP Cases and Controls in Pandemic Influenza Working Group, Spain.

    Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain.

    INFLUENZA AND OTHER RESPIRATORY VIRUSES . 7(6): 1336-1342. Number of citations: 5

    [doi:10.1111/irv.12119]

  • Díez-Aguilar M, Morosini MI, del Campo R, García-Castillo M, Zamora J, Cantón R.

    In Vitro Activity of Fosfomycin against a Collection of Clinical Pseudomonas aeruginosa Isolates from 16 Spanish Hospitals: Establishing the Validity of Standard Broth Microdilution as Susceptibility Testing Method

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY . 57(11): 5701-5703. Number of citations: 28

    [doi:10.1128/AAC.00589-13]

  • Tenover FC, Canton R, Kop J, Chan R, Ryan J, Weir F, Ruiz-Garbajosa P, LaBombardi V, Persing DH.

    Detection of Colonization by Carbapenemase-Producing Gram-Negative Bacilli in Patients by Use of the Xpert MDRO Assay

    JOURNAL OF CLINICAL MICROBIOLOGY . 51(11): 3780-3787. Number of citations: 63

    [doi:10.1128/JCM.01092-13]

  • Ruiz-Garbajosa P, Curiao T, Tato M, Gijón D, Pintado V, Valverde A, Baquero F, Morosini MI, Coque TM, Cantón R.

    Multiclonal dispersal of KPC genes following the emergence of non-ST258 KPC-producing Klebsiella pneumoniae clones in Madrid, Spain.

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY . 68(11): 2487-2492. Number of citations: 42

    [doi:10.1093/jac/dkt237]

  • Reales-Calderón JA, Sylvester M, Strijbis K, Jensen ON, Nombela C, Molero G, Gil C.

    Candida albicans induces pro-inflammatory and anti-apoptotic signals in macrophages as revealed by quantitative proteomics and phosphoproteomics

    JOURNAL OF PROTEOMICS . 91: 106-135. Number of citations: 31

    [doi:10.1016/j.jprot.2013.06.026]

  • Morosini MI, Quereda C, Gil H, Anda P, Núñez-Murga M, Cantón R, López-Vélez R.

    Melioidosis in Traveler from Africa to Spain

    EMERGING INFECTIOUS DISEASES . 19(10): 1656-1659. Number of citations: 21

    [doi:10.3201/eid1910.121785]

  • Wu G, Day MJ, Mafura MT, Nunez-Garcia J, Fenner JJ, Sharma M, van Essen-Zandbergen A, Rodríguez I, Dierikx C, Kadlec K, Schink AK, Chattaway M, Wain J, Helmuth R, Guerra B, Schwarz S, Threlfall J, Woodward MJ, Woodford N, Coldham N, Mevius D.

    Comparative Analysis of ESBL-Positive Escherichia coli Isolates from Animals and Humans from the UK, The Netherlands and Germany

    Plos One . 8(9): . Number of citations: 107

    [doi:10.1371/journal.pone.0075392]

  • Turrientes MC, Baquero F, Levin BR, Martínez JL, Ripoll A, González-Alba JM, Tobes R, Manrique M, Baquero MR, Rodríguez-Domínguez MJ, Cantón R, Galán JC.

    Normal mutation rate variants arise in a Mutator (Mut S) Escherichia coli population.

    Plos One . 8(9): . Number of citations: 29

    [doi:10.1371/journal.pone.0072963]

  • Cantón R, Horcajada JP, Oliver A, Garbajosa PR, Vila J.

    Inappropriate use of antibiotics in hospitals: the complex relationship between antibiotic use and antimicrobial resistance.

    ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA . 31 Suppl 4: 3-11.

    [doi:10.1016/S0213-005X(13)70126-5]

  • Gútiez L, Gómez-Sala B, Recio I, del Campo R, Cintas LM, Herranz C, Hernández PE.

    Enterococcus faecalis strains from food, environmental, and clinical origin produce ACE-inhibitory peptides and other bioactive peptides during growth in bovine skim milk

    INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY . 166(1): 93-101. Number of citations: 22

    [doi:10.1016/j.ijfoodmicro.2013.06.019]

  • de Toro M, García P, Rodríguez I, Rojo-Bezares B, Helmuth R, Sáenz Y, Rodicio MR, Guerra B, Torres C.

    Characterisation of plasmids implicated in the mobilisation of extended-spectrum and AmpC beta-lactamase genes in clinical Salmonella enterica isolates and temporal stability of the resistance genotype

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS . 42(2): 167-172. Number of citations: 12

    [doi:10.1016/j.ijantimicag.2013.04.016]

  • Holguín A, Norman F, Martín L, Mateos ML, Chacón J, López-Vélez R, Pérez-Molina JA.

    Dried blood as an alternative to plasma or serum for Trypanosoma cruzi IgG detection in screening programs.

    CLINICAL AND VACCINE IMMUNOLOGY . 20(8): 1197-1202. Number of citations: 17

    [doi:10.1128/CVI.00221-13]

  • Werner G, Coque TM, Franz CM, Grohmann E, Hegstad K, Jensen L, van Schaik W, Weaver K.

    Antibiotic resistant enterococci-Tales of a drug resistance gene trafficker

    INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY . 303(6-7): 360-379. Number of citations: 108

    [doi:10.1016/j.ijmm.2013.03.001]

  • Fernández-Olmos A, García-Castillo M, Alba JM, Morosini MI, Lamas A, Romero B, Galán JC, del Campo R, Cantón R.

    Population Structure and Antimicrobial Susceptibility of Both Nonpersistent and Persistent Pseudomonas aeruginosa Isolates Recovered from Cystic Fibrosis Patients

    JOURNAL OF CLINICAL MICROBIOLOGY . 51(8): 2761-2765. Number of citations: 19

    [doi:10.1128/JCM.00802-13]

  • Castilla J, Godoy P, Domínguez A, Martínez-Baz I, Astray J, Martín V, Delgado-Rodríguez M, Baricot M, Soldevila N, Mayoral JM, Quintana JM, Galán JC, Castro A, González-Candelas F, Garín O, Saez M, Tamames S, Pumarola T.

    Influenza Vaccine Effectiveness in Preventing Outpatient, Inpatient, and Severe Cases of Laboratory-Confirmed Influenza

    CLINICAL INFECTIOUS DISEASES . 57(2): 167-175. Number of citations: 90

    [doi:10.1093/cid/cit194]

  • Pagán I, Holguín A.

    Reconstructing the timing and dispersion routes of HIV-1 subtype B epidemics in the Caribbean and Central America: a phylogenetic story.

    Plos One . 8(7): . Number of citations: 12

    [doi:10.1371/journal.pone.0069218]

  • Vázquez C, Botella-Carretero JI, García-Albiach R, Pozuelo MJ, Rodríguez-Baños M, Baquero F, Baltadjieva MA, del Campo R.

    Screening in a Lactobacillus delbrueckii subsp. bulgaricus collection to select a strain able to survive to the human intestinal tract.

    NUTRICION HOSPITALARIA . 28(4): 1227-1235. Number of citations: 6

    [doi:10.3305/nh.2013.28.4.6540]