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Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

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Only original articles, editorials, guidelines.

  • García-Castillo M, Máiz L, Morosini MI, Rodríguez-Baños M, Suarez L, Fernández-Olmos A, Baquero F, Cantón R, del Campo R.

    Emergence of a mutL mutation causing multilocus sequence typing-pulsed-field gel electrophoresis discrepancy among Pseudomonas aeruginosa isolates from a cystic fibrosis patient.

    JOURNAL OF CLINICAL MICROBIOLOGY . 50(5): 1777-1778. Number of citations: 19

    [doi:10.1128/JCM.05478-11]

  • Cantón R, Akóva M, Carmeli Y, Giske CG, Glupczynski Y, Gniadkowski M, Livermore DM, Miriagou V, Naas T, Rossolini GM, Samuelsen Ø, Seifert H, Woodford N, Nordmann P.

    Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe

    CLINICAL MICROBIOLOGY AND INFECTION . 18(5): 413-431. Number of citations: 607

    [doi:10.1111/j.1469-0691.2012.03821.x]

  • Novais Â, Viana D, Baquero F, Martínez-Botas J, Cantón R, Coque TM.

    Contribution of IncFII and broad-host IncA/C and IncN plasmids to the local expansion and diversification of phylogroup B2 Escherichia coli ST131 clones carrying blaCTX-M-15 and qnrS1 genes.

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY . 56(5): 2763-2766. Number of citations: 23

    [doi:10.1128/AAC.06001-11]

  • Valdezate S, Miranda C, Navarro A, Freitas AR, Cabrera JJ, Carrasco G, Coque TM, Jiménez-Romano E, Saéz-Nieto JA.

    Clonal outbreak of ST17 multidrug-resistant Enterococcus faecium harbouring an Inc18-like::Tn1546 plasmid in a haemo-oncology ward of a Spanish hospital

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY . 67(4): 832-836. Number of citations: 23

    [doi:10.1093/jac/dkr545]

  • Ruiz-Garbajosa P, de Regt M, Bonten M, Baquero F, Coque TM, Cantón R, Harmsen HJ, Willems RJ.

    High-density fecal Enterococcus faecium colonization in hospitalized patients is associated with the presence of the polyclonal subcluster CC17.

    EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES . 31(4): 519-522. Number of citations: 20

    [doi:10.1007/s10096-011-1342-7]

  • González-Candelas F, Astray J, Alonso J, Castro A, Cantón R, Galán JC, Garin O, Sáez M, Soldevila N, Baricot M, Castilla J, Godoy P, Delgado-Rodríguez M, Martín V, Mayoral JM, Pumarola T, Quintana JM, Tamames S, Domínguez A.

    Sociodemographic factors and clinical conditions associated to hospitalization in influenza A (H1N1) 2009 virus infected patients in Spain, 2009-2010.

    Plos One . 7(3): . Number of citations: 13

    [doi:10.1371/journal.pone.0033139]

  • Kuch A, Willems RJ, Werner G, Coque TM, Hammerum AM, Sundsfjord A, Klare I, Ruiz-Garbajosa P, Simonsen GS, van Luit-Asbroek M, Hryniewicz W, Sadowy E.

    Insight into antimicrobial susceptibility and population structure of contemporary human Enterococcus faecalis isolates from Europe

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY . 67(3): 551-558. Number of citations: 75

    [doi:10.1093/jac/dkr544]

  • Fernández-Olmos A, Morosini MI, Lamas A, García-Castillo M, García-García L, Cantón R, Máiz L.

    Clinical and Microbiological Features of a Cystic Fibrosis Patient Chronically Colonized with Pandoraea sputorum Identified by Combining 16S rRNA Sequencing and Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry

    JOURNAL OF CLINICAL MICROBIOLOGY . 50(3): 1096-1098. Number of citations: 21

    [doi:10.1128/JCM.05730-11]

  • Mouton JW, Brown DF, Apfalter P, Cantón R, Giske CG, Ivanova M, MacGowan AP, Rodloff A, Soussy CJ, Steinbakk M, Kahlmeter G.

    The role of pharmacokinetics/pharmacodynamics in setting clinical MIC breakpoints: the EUCAST approach

    CLINICAL MICROBIOLOGY AND INFECTION . 18(3): 37-45. Number of citations: 183

    [doi:10.1111/j.1469-0691.2011.03752.x]

  • Hawser SP, Bouchillon SK, Lascols C, Hackel M, Hoban DJ, Badal RE, Cantón R.

    Susceptibility of European Escherichia coli clinical isolates from intra-abdominal infections, extended-spectrum beta-lactamase occurrence, resistance distribution, and molecular characterization of ertapenem-resistant isolates (SMART 2008-2009)

    CLINICAL MICROBIOLOGY AND INFECTION . 18(3): 253-259. Number of citations: 34

    [doi:10.1111/j.1469-0691.2011.03550.x]

  • Yebra G, de Mulder M, Martín L, Rodríguez C, Labarga P, Viciana I, Berenguer J, Alemán MR, Pineda JA, García F, Holguín A.

    Most HIV type 1 non-B infections in the Spanish cohort of antiretroviral treatment-naïve HIV-infected patients (CoRIS) are due to recombinant viruses.

    JOURNAL OF CLINICAL MICROBIOLOGY . 50(2): 407-413. Number of citations: 34

    [doi:10.1128/JCM.05798-11]

  • Martín V, Maldonado-Barragán A, Moles L, Rodriguez-Baños M, Campo RD, Fernández L, Rodríguez JM, Jiménez E.

    Sharing of Bacterial Strains Between Breast Milk and Infant Feces

    JOURNAL OF HUMAN LACTATION . 28(1): 36-44. Number of citations: 212

    [doi:10.1177/0890334411424729]

  • Fernández-Olmos A, García-Castillo M, Morosini MI, Lamas A, Máiz L, Cantón R.

    MALDI-TOF MS improves routine identification of non-fermenting Gram negative isolates from cystic fibrosis patients

    JOURNAL OF CYSTIC FIBROSIS . 11(1): 59-62. Number of citations: 68

    [doi:10.1016/j.jcf.2011.09.001]

  • Cantón R, González-Alba JM, Galán JC.

    CTX-M enzymes: origin and diffusion

    FRONTIERS IN MICROBIOLOGY . 3: 110-110. Number of citations: 524

    [doi:10.3389/fmicb.2012.00110]

  • del Campo R, Martínez E, del Fresno C, Alenda R, Gómez-Piña V, Fernández-Ruíz I, Siliceo M, Jurado T, Toledano V, Arnalich F, García-Río F, López-Collazo E.

    Translocated LPS might cause endotoxin tolerance in circulating monocytes of cystic fibrosis patients.

    Plos One . 6(12): . Number of citations: 29

    [doi:10.1371/journal.pone.0029577]

  • Martínez García MÁ, Máiz Carro L, Catalán Serra P.

    Treatment of Non-Cystic Fibrosis Bronchiectasis

    ARCHIVOS DE BRONCONEUMOLOGIA . 47(12): 599-609. Number of citations: 13

    [doi:10.1016/j.arbres.2011.06.003]

  • Cantón R, Loza E, Aznar J, Calvo J, Cercenado E, Cisterna R, Romo FG, Hontangas JL, Calvo CR, Barrenechea AI, Tubau F, Weber I, Yuste P, Cavanillas R.

    Antimicrobial susceptibility of Gram-negative organisms from intraabdominal infections and evolution of isolates with extended spectrum ß-lactamases in the SMART study in Spain (2002-2010).

    REVISTA ESPANOLA DE QUIMIOTERAPIA . 24(4): 223-232. Number of citations: 27

  • D'Auria G, Galán JC, Rodríguez-Alcayna M, Moya A, Baquero F, Latorre A.

    Complete genome sequence of Acidaminococcus intestini RYC-MR95, a Gram-negative bacterium from the phylum Firmicutes.

    JOURNAL OF BACTERIOLOGY . 193(24): 7008-7009. Number of citations: 12

    [doi:10.1128/JB.06301-11]