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Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

Search for publications

Only original articles, editorials, guidelines.

  • Werner G, Freitas AR, Coque TM, Sollid JE, Lester C, Hammerum AM, Garcia-Migura L, Jensen LB, Francia MV, Witte W, Willems RJ, Sundsfjord A.

    Host range of enterococcal vanA plasmids among Gram-positive intestinal bacteria.

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY . 66(2): 273-282. Number of citations: 47

    [doi:10.1093/jac/dkq455]

  • Laverde Gomez JA, van Schaik W, Freitas AR, Coque TM, Weaver KE, Francia MV, Witte W, Werner G.

    A multiresistance megaplasmid pLG1 bearing a hylEfm genomic island in hospital Enterococcus faecium isolates.

    INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY . 301(2): 165-175. Number of citations: 60

    [doi:10.1016/j.ijmm.2010.08.015]

  • Yebra G, de Mulder M, Martín L, Pérez-Cachafeiro S, Rodríguez C, Labarga P, García F, Tural C, Jaén A, Navarro G, Holguín A.

    Sensitivity of seven HIV subtyping tools differs among subtypes/recombinants in the Spanish cohort of naïve HIV-infected patients (CoRIS).

    ANTIVIRAL RESEARCH . 89(1): 19-25. Number of citations: 19

    [doi:10.1016/j.antiviral.2010.10.008]

  • Cantón R, Lumb J.

    Emerging resistance in Gram-negative pathogens and implications for clinical practice.

    Future Microbiology . 6(1): 19-22.

    [doi:10.2217/fmb.10.150]

  • Asensio A, Alvarez-Espejo T, Fernandez-Crehuet J, Ramos A, Vaque-Rafart J, Bishopberger C, Hernandez Navarrete M, Calbo-Torrecillas F, Campayo J, Canton R.

    Trends in yearly prevalence of third-generation cephalosporin and fluoroquinolone resistant Enterobacteriaceae infections and antimicrobial use in Spanish hospitals, Spain, 1999 to 2010.

    Eurosurveillance . 16(40): .

  • Gorantla S, Makarov E, Finke-Dwyer J, Castanedo A, Holguin A, Gebhart CL, Gendelman HE, Poluektova L.

    Links between progressive HIV-1 infection of humanized mice and viral neuropathogenesis.

    AMERICAN JOURNAL OF PATHOLOGY . 177(6): 2938-2949. Number of citations: 71

    [doi:10.2353/ajpath.2010.100536]

  • de Arellano ER, Alcamí J, López M, Soriano V, Holguín A.

    Drastic decrease of transcription activity due to hypermutated long terminal repeat (LTR) region in different HIV-1 subtypes and recombinants.

    ANTIVIRAL RESEARCH . 88(2): 152-159. Number of citations: 9

    [doi:10.1016/j.antiviral.2010.08.007]

  • Tato M, Morosini M, García L, Albertí S, Coque MT, Cantón R.

    Carbapenem Heteroresistance in VIM-1-Producing Klebsiella pneumoniae Isolates Belonging to the Same Clone: Consequences for Routine Susceptibility Testing

    JOURNAL OF CLINICAL MICROBIOLOGY . 48(11): 4089-4093. Number of citations: 48

    [doi:10.1128/JCM.01130-10]

  • Gómez García I, Gómez Mampaso E, Burgos Revilla J, Molina MR, Sampietro Crespo A, Buitrago LA, Gómez Rodríguez A, Baquero F.

    Tuberculous orchiepididymitis during 1978-2003 period: review of 34 cases and role of 16S rRNA amplification.

    Urology . 76(4): 776-781. Number of citations: 8

    [doi:10.1016/j.urology.2010.01.033]

  • Antunes P, Coque TM, Peixe L.

    Emergence of an IncI? plasmid encoding CMY-2 ß-lactamase associated with the international ST19 OXA-30-producing ß-lactamase Salmonella Typhimurium multidrug-resistant clone.

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY . 65(10): 2097-2100. Number of citations: 20

    [doi:10.1093/jac/dkq293]

  • Zamorano L, Juan C, Fernández-Olmos A, Ge Y, Cantón R, Oliver A.

    Activity of the new cephalosporin CXA-101 (FR264205) against Pseudomonas aeruginosa isolates from chronically-infected cystic fibrosis patients.

    CLINICAL MICROBIOLOGY AND INFECTION . 16(9): 1482-1487.

    [doi:10.1111/j.1469-0691.2009.03130.x]

  • Paniagua R, Valverde A, Coque TM, Baquero F, Cantón R.

    Assessment of prevalence and changing epidemiology of extended-spectrum beta-lactamase-producing Enterobacteriaceae fecal carriers using a chromogenic medium.

    DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE . 67(4): 376-379. Number of citations: 28

    [doi:10.1016/j.diagmicrobio.2010.03.012]

  • Curiao T, Morosini MI, Ruiz-Garbajosa P, Robustillo A, Baquero F, Coque TM, Cantón R.

    Emergence of bla KPC-3-Tn4401a associated with a pKPN3/4-like plasmid within ST384 and ST388 Klebsiella pneumoniae clones in Spain.

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY . 65(8): 1608-1614. Number of citations: 69

    [doi:10.1093/jac/dkq174]

  • Hawser SP, Bouchillon SK, Hoban DJ, Badal RE, Cantón R, Baquero F.

    Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrobial Resistance Trends (SMART).

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY . 54(7): 3043-3046. Number of citations: 68

    [doi:10.1128/AAC.00265-10]

  • Martín O, Valverde A, Morosini MI, Rodríguez-Domínguez M, Rodríguez-Baños M, Coque TM, Cantón R, del Campo R.

    Population analysis and epidemiological features of inhibitor-resistant-TEM-beta-lactamase-producing Escherichia coli isolates from both community and hospital settings in Madrid, Spain.

    JOURNAL OF CLINICAL MICROBIOLOGY . 48(7): 2368-2372. Number of citations: 17

    [doi:10.1128/JCM.00608-10]

  • Friaza V, la Horra Cd, Rodríguez-Domínguez MJ, Martín-Juan J, Cantón R, Calderón EJ, Del Campo R.

    Metagenomic analysis of bronchoalveolar lavage samples from patients with idiopathic interstitial pneumonia and its antagonic relation with Pneumocystis jirovecii colonization

    JOURNAL OF MICROBIOLOGICAL METHODS . 82(1): 98-101. Number of citations: 26

    [doi:10.1016/j.mimet.2010.03.026]

  • Pfaller MA, Diekema DJ, Gibbs DL, Newell VA, Barton R, Bijie H, Bille J, Chang SC, da Luz Martins M, Duse A, Dzierzanowska D, Ellis D, Finquelievich J, Gould I, Gur D, Hoosen A, Lee K, Mallatova N, Mallie M, Peng NG, Petrikos G, Santiago A, Trupl J, VanDen Abeele AM, Wadula J, Zaidi M.

    Geographic variation in the frequency of isolation and fluconazole and voriconazole susceptibilities of Candida glabrata: an assessment from the ARTEMIS DISK Global Antifungal Surveillance Program

    DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE . 67(2): 162-171. Number of citations: 62

    [doi:10.1016/j.diagmicrobio.2010.01.002]

  • Hegstad K, Mikalsen T, Coque TM, Werner G, Sundsfjord A.

    Mobile genetic elements and their contribution to the emergence of antimicrobial resistant Enterococcus faecalis and Enterococcus faecium.

    CLINICAL MICROBIOLOGY AND INFECTION . 16(6): 541-554. Number of citations: 206

    [doi:10.1111/j.1469-0691.2010.03226.x]