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Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

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Only original articles, editorials, guidelines.

  • Romero-Hernández B, Tedim AP, Sánchez-Herrero JF, Librado P, Rozas J, Muñoz G, Baquero F, Cantón R, Del Campo R.

    Streptococcus gallolyticus subsp. gallolyticus from human and animal origins: genetic diversity, antimicrobial susceptibility, and characterization of a vancomycin-resistant calf isolate carrying a vanA-Tn1546-like element.

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY . 59(4): 2006-2015. Number of citations: 13

    [doi:10.1128/AAC.04083-14]

  • Lanza VF, Tedim AP, Martínez JL, Baquero F, Coque TM.

    The Plasmidome of Firmicutes: Impact on the Emergence and the Spread of Resistance to Antimicrobials.

    Microbiology spectrum . 3(2): . Number of citations: 59

    [doi:10.1128/microbiolspec.PLAS-0039-2014]

  • García-Fernández S, Morosini MI, Marco F, Gijón D, Vergara A, Vila J, Ruiz-Garbajosa P, Cantón R.

    Evaluation of the eazyplex (R) SuperBug CRE system for rapid detection of carbapenemases and ESBLs in clinical Enterobacteriaceae isolates recovered at two Spanish hospitals

    The Journal of antimicrobial chemotherapy . 70(4): 1047-1050. Number of citations: 41

    [doi:10.1093/jac/dku476]

  • Curiao T, Marchi E, Viti C, Oggioni MR, Baquero F, Martinez JL, Coque TM.

    Polymorphic variation in susceptibility and metabolism of triclosan-resistant mutants of Escherichia coli and Klebsiella pneumoniae clinical strains obtained after exposure to biocides and antibiotics.

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY . 59(6): 3413-3423. Number of citations: 24

    [doi:10.1128/AAC.00187-15]

  • Zischka M, Künne CT, Blom J, Wobser D, Sak?nç T, Schmidt-Hohagen K, Dabrowski PW, Nitsche A, Hübner J, Hain T, Chakraborty T, Linke B, Goesmann A, Voget S, Daniel R, Schomburg D, Hauck R, Hafez HM, Tielen P, Jahn D, Solheim M, Sadowy E, Larsen J, Jensen LB, Ruiz-Garbajosa P, Quiñones Pérez D, Mikalsen T, Bender J, Steglich M, Nübel U, Witte W, Werner G.

    Comprehensive molecular, genomic and phenotypic analysis of a major clone of Enterococcus faecalis MLST ST40

    Bmc Genomics . 16: 175-175. Number of citations: 22

    [doi:10.1186/s12864-015-1367-x]

  • Cantón R, Máiz L, Escribano A, Olveira C, Oliver A, Asensio O, Gartner S, Roma E, Quintana-Gallego E, Salcedo A, Girón R, Barrio MI, Pastor MD, Prados C, Martínez-Martínez MT, Barberán J, Castón JJ, Martínez-Martínez L, Poveda JL, Vázquez C, de Gracia J, Solé A.

    Spanish Consensus on the Prevention and Treatment of Pseudomonas aeruginosa Bronchial Infections in Cystic Fibrosis Patients

    ARCHIVOS DE BRONCONEUMOLOGIA . 51(3): 140-150. Number of citations: 29

    [doi:10.1016/j.arbres.2014.09.021]

  • Valverde A, Turrientes MC, Norman F, San Martín E, Moreno L, Pérez-Molina JA, López-Vélez R, Cantón R.

    CTX-M-15-non-ST131 Escherichia coli isolates are mainly responsible of faecal carriage with ESBL-producing Enterobacteriaceae in travellers, immigrants and those visiting friends and relatives

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases . 21(3): . Number of citations: 24

    [doi:10.1016/j.cmi.2014.09.021]

  • Pérez-Losada M, Arenas M, Galán JC, Palero F, González-Candelas F.

    Recombination in viruses: Mechanisms, methods of study, and evolutionary consequences

    INFECTION GENETICS AND EVOLUTION . 30: 296-307. Number of citations: 135

    [doi:10.1016/j.meegid.2014.12.022]

  • López-Collazo E, Jurado T, de Dios Caballero J, Pérez-Vázquez M, Vindel A, Hernández-Jiménez E, Tamames J, Cubillos-Zapata C, Manrique M, Tobes R, Máiz L, Cantón R, Baquero F, Del Campo R.

    In vivo attenuation and genetic evolution of a ST247-SCCmecI MRSA clone after 13 years of pathogenic bronchopulmonary colonization in a patient with cystic fibrosis: implications of the innate immune response.

    MUCOSAL IMMUNOLOGY . 8(2): 362-371. Number of citations: 12

    [doi:10.1038/mi.2014.73]

  • Tedim AP, Ruiz-Garbajosa P, Corander J, Rodríguez CM, Cantón R, Willems RJ, Baquero F, Coque TM.

    Population biology of intestinal enterococcus isolates from hospitalized and nonhospitalized individuals in different age groups.

    APPLIED AND ENVIRONMENTAL MICROBIOLOGY . 81(5): 1820-1831. Number of citations: 55

    [doi:10.1128/AEM.03661-14]

  • Baquero F, Lanza VF, Cantón R, Coque TM.

    Public health evolutionary biology of antimicrobial resistance: priorities for intervention.

    EVOLUTIONARY APPLICATIONS . 8(3): 223-239. Number of citations: 37

    [doi:10.1111/eva.12235]

  • Shaw E, Benito N, Rodríguez-Baño J, Padilla B, Pintado V, Calbo E, Pallarés MA, Gozalo M, Ruiz-Garbajosa P, Horcajada JP.

    Risk factors for severe sepsis in community-onset bacteraemic urinary tract infection: Impact of antimicrobial resistance in a large hospitalised cohort

    JOURNAL OF INFECTION . 70(3): 247-254. Number of citations: 13

    [doi:10.1016/j.jinf.2014.09.011]

  • Cueva C, Bartolomé B, Moreno-Arribas MV, Bustos I, Requena T, González-Manzano S, Santos-Buelga C, Turrientes MC, del Campo R.

    Susceptibility and Tolerance of Human Gut Culturable Aerobic Microbiota to Wine Polyphenols

    MICROBIAL DRUG RESISTANCE . 21(1): 17-24. Number of citations: 3

    [doi:10.1089/mdr.2014.0074]

  • Cano Megías M, González Albarrán O, Guisado Vasco P, Lamas Ferreiro A, Máiz Carro L.

    Insulin resistance, beta-cell dysfunction and differences in curves of plasma glucose and insulin in the intermediate points of the standard glucose tolerance test in adults with cystic fibrosis

    ENDOCRINOLOGIA Y NUTRICION . 62(2): 91-99. Number of citations: 14

    [doi:10.1016/j.endonu.2014.08.002]

  • Fernández McPhee C, Álvarez P, Prieto L, Obiang J, Avedillo P, Vargas A, Rojo P, Abad C, Ramos JT, Holguín A.

    HIV-1 infection using dried blood spots can be confirmed by Bio-Rad Geenius™ HIV 1/2 confirmatory assay.

    JOURNAL OF CLINICAL VIROLOGY . 63: 66-69. Number of citations: 9

    [doi:10.1016/j.jcv.2014.12.018]

  • Báez J, Hernández-García M, Guamparito C, Díaz S, Olave A, Guerrero K, Cantón R, Baquero F, Gahona J, Valenzuela N, Del Campo R, Silva J.

    Molecular characterization and genetic diversity of ESBL-producing Escherichia coli colonizing the migratory Franklin's gulls (Leucophaeus pipixcan) in Antofagasta, North of Chile.

    MICROBIAL DRUG RESISTANCE . 21(1): 111-116. Number of citations: 34

    [doi:10.1089/mdr.2014.0158]

  • Martínez JL, Coque TM, Baquero F.

    What is a resistance gene? Ranking risk in resistomes.

    NATURE REVIEWS MICROBIOLOGY . 13(2): 116-123. Number of citations: 443

    [doi:10.1038/nrmicro3399]

  • Brown D, Canton R, Dubreuil L, Gatermann S, Giske C, MacGowan A, Martinez-Martinez L, Mouton J, Skov R, Steinbakk M, Walton C, Heuer O, Struelens MJ, Diaz Hogberg L, Kahlmeter G.

    Widespread implementation of EUCAST breakpoints for antibacterial susceptibility testing in Europe

    Eurosurveillance . 20(2): 21-28. Number of citations: 23

    [doi:10.2807/1560-7917.ES2015.20.2.21008]