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Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

Search for publications

Only original articles, editorials, guidelines.

  • Camargo JF, Simkins J, Beduschi T, Tekin A, Aragon L, Pérez-Cardona A, Prado CE, Morris MI, Abbo LM, Cantón R.

    Successful Treatment of Carbapenemase-Producing Pandrug-Resistant Klebsiella pneumoniae Bacteremia

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY . 59(10): 5903-5908. Number of citations: 41

    [doi:10.1128/AAC.00655-15]

  • Díez-Aguilar M, Morosini MI, Tedim AP, Rodríguez I, Aktas Z, Cantón R.

    Antimicrobial Activity of Fosfomycin-Tobramycin Combination against Pseudomonas aeruginosa Isolates Assessed by Time-Kill Assays and Mutant Prevention Concentrations

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY . 59(10): 6039-6045. Number of citations: 24

    [doi:10.1128/AAC.00822-15]

  • Garcia-Etxebarria K, Bracho MA, Galán JC, Pumarola T, Castilla J, Ortiz de Lejarazu R, Rodríguez-Dominguez M, Quintela I, Bonet N, Garcia-Garcerà M, Domínguez A, González-Candelas F, Calafell F.

    No Major Host Genetic Risk Factor Contributed to A(H1N1)2009 Influenza Severity

    Plos One . 10(9): . Number of citations: 15

    [doi:10.1371/journal.pone.0135983]

  • Gil-Bona A, Parra-Giraldo CM, Hernáez ML, Reales-Calderon JA, Solis NV, Filler SG, Monteoliva L, Gil C.

    Candida albicans cell shaving uncovers new proteins involved in cell wall integrity, yeast to hypha transition, stress response and host-pathogen interaction

    JOURNAL OF PROTEOMICS . 127(B): 340-351. Number of citations: 45

    [doi:10.1016/j.jprot.2015.06.006]

  • Reales-Calderón JA, Corona F, Monteoliva L, Gil C, Martínez JL.

    Quantitative proteomics unravels that the post-transcriptional regulator Crc modulates the generation of vesicles and secreted virulence determinants of Pseudomonas aeruginosa

    JOURNAL OF PROTEOMICS . 127(B): 352-364. Number of citations: 18

    [doi:10.1016/j.jprot.2015.06.009]

  • Smith H, Bossers A, Harders F, Wu G, Woodford N, Schwarz S, Guerra B, Rodríguez I, van Essen-Zandbergen A, Brouwer M, Mevius D.

    Characterization of Epidemic IncI1-I gamma Plasmids Harboring Ambler Class A and C Genes in Escherichia coli and Salmonella enterica from Animals and Humans

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY . 59(9): 5357-5365. Number of citations: 43

    [doi:10.1128/AAC.05006-14]

  • Reales-Calderón JA, Corona F, Monteoliva L, Gil C, Martínez JL.

    Quantitative proteomics unravels that the post-transcriptional regulator Crc modulates the generation of vesicles and secreted virulence determinants of Pseudomonas aeruginosa.

    Data in brief . 4: 450-453.

    [doi:10.1016/j.dib.2015.07.002]

  • Alvarez P, Martín L, Prieto L, Obiang J, Vargas A, Avedillo P, Rojo P, Fernández McPhee C, Benito A, Ramos JT, Holguín Á.

    HIV-1 variability and viral load technique could lead to false positive HIV-1 detection and to erroneous viral quantification in infected specimens.

    JOURNAL OF INFECTION . 71(3): 368-376. Number of citations: 15

    [doi:10.1016/j.jinf.2015.05.011]

  • Campos M, Llorens C, Sempere JM, Futami R, Rodriguez I, Carrasco P, Capilla R, Latorre A, Coque TM, Moya A, Baquero F.

    A membrane computing simulator of trans-hierarchical antibiotic resistance evolution dynamics in nested ecological compartments (ARES).

    BIOLOGY DIRECT . 10(1): 41-41. Number of citations: 14

    [doi:10.1186/s13062-015-0070-9]

  • Theuretzbacher U, Van Bambeke F, Cantón R, Giske CG, Mouton JW, Nation RL, Paul M, Turnidge JD, Kahlmeter G.

    Reviving old antibiotics

    The Journal of antimicrobial chemotherapy . 70(8): 2177-2181. Number of citations: 62

    [doi:10.1093/jac/dkv157]

  • Cabal A, Geue L, Gómez-Barrero S, Barth S, Bárcena C, Hamm K, Porrero MC, Valverde A, Cantón R, Menge C, Gortázar C, Domínguez L, Álvarez J.

    Detection of virulence-associated genes characteristic of intestinal Escherichia coli pathotypes, including the enterohemorrhagic/enteroaggregative O104:H4, in bovines from Germany and Spain

    MICROBIOLOGY AND IMMUNOLOGY . 59(8): 433-442. Number of citations: 11

    [doi:10.1111/1348-0421.12275]

  • Díez-Aguilar M, Morosini MI, López-Cerero L, Pascual Á, Calvo J, Martínez-Martínez L, Marco F, Vila J, Ortega A, Oteo J, Cantón R.

    Performance of EUCAST and CLSI approaches for co-amoxiclav susceptibility testing conditions for clinical categorization of a collection of Escherichia coli isolates with characterized resistance phenotypes

    The Journal of antimicrobial chemotherapy . 70(8): 2306-2310. Number of citations: 11

    [doi:10.1093/jac/dkv088]

  • Marcos-Zambrano LJ, Escribano P, Sanguinetti M, Gómez G de la Pedrosa E, De Carolis E, Vella A, Cantón R, Bouza E, Guinea J.

    Clusters of patients with candidaemia due to genotypes of Candida albicans and Candida parapsilosis: differences in frequency between hospitals

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases . 21(7): 677-683. Number of citations: 10

    [doi:10.1016/j.cmi.2015.03.007]

  • Roca I, Akova M, Baquero F, Carlet J, Cavaleri M, Coenen S, Cohen J, Findlay D, Gyssens I, Heure OE, Kahlmeter G, Kruse H, Laxminarayan R, Liébana E, López-Cerero L, MacGowan A, Martins M, Rodríguez-Baño J, Rolain JM, Segovia C, Sigauque B, Taconelli E, Wellington E, Vila J.

    The global threat of antimicrobial resistance: science for intervention.

    New microbes and new infections . 6: 22-29.

    [doi:10.1016/j.nmni.2015.02.007]

  • Fernández-Cooke E, Rojas P, Holguin A, Tomé MI, Jimenez de Ory S, Mellado MJ, Navarro ML, Rojo P, Ramos JT.

    Description and consequences of prescribing off-label antiretrovirals in the Madrid Cohort of HIV-infected children over a quarter of a century (1988-2012).

    ANTIVIRAL THERAPY . 21(1): 65-70. Number of citations: 4

    [doi:10.3851/IMP2973]

  • Torner N, Soldevila N, Garcia JJ, Launes C, Godoy P, Castilla J, Domínguez A.

    Effectiveness of non-pharmaceutical measures in preventing pediatric influenza: a case-control study

    Bmc Public Health . 15: 543-543. Number of citations: 15

    [doi:10.1186/s12889-015-1890-3]

  • Rojas Sánchez P, de Mulder M, Fernandez-Cooke E, Prieto L, Rojo P, Jiménez de Ory S, José Mellado M, Navarro M, Tomas Ramos J, Holguín Á, Madrid Cohort of HIV-Infected Children and Adolescents Integrated in the Paediat.

    Clinical and virologic follow-up in perinatally HIV-1-infected children and adolescents in Madrid with triple-class antiretroviral drug-resistant viruses.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases . 21(6): . Number of citations: 7

    [doi:10.1016/j.cmi.2015.02.003]

  • Oteo J, Ortega A, Bartolomé R, Bou G, Conejo C, Fernández-Martínez M, González-López JJ, Martínez-García L, Martínez-Martínez L, Merino M, Miró E, Mora M, Navarro F, Oliver A, Pascual Á, Rodríguez-Baño J, Ruiz-Carrascoso G, Ruiz-Garbajosa P, Zamorano L, Bautista V, Pérez-Vázquez M, Campos J, GEIH-GEMARA (SEIMC) and REIPI.

    Prospective Multicenter Study of Carbapenemase-Producing Enterobacteriaceae from 83 Hospitals in Spain Reveals High In Vitro Susceptibility to Colistin and Meropenem

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY . 59(6): 3406-3412. Number of citations: 98

    [doi:10.1128/AAC.00086-15]