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Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

Search for publications

Only original articles, editorials, guidelines.

  • Smith H, Bossers A, Harders F, Wu G, Woodford N, Schwarz S, Guerra B, Rodríguez I, van Essen-Zandbergen A, Brouwer M, Mevius D.

    Characterization of Epidemic IncI1-I gamma Plasmids Harboring Ambler Class A and C Genes in Escherichia coli and Salmonella enterica from Animals and Humans

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY . 59(9): 5357-5365. Number of citations: 43

    [doi:10.1128/AAC.05006-14]

  • Reales-Calderón JA, Corona F, Monteoliva L, Gil C, Martínez JL.

    Quantitative proteomics unravels that the post-transcriptional regulator Crc modulates the generation of vesicles and secreted virulence determinants of Pseudomonas aeruginosa.

    Data in brief . 4: 450-453.

    [doi:10.1016/j.dib.2015.07.002]

  • Alvarez P, Martín L, Prieto L, Obiang J, Vargas A, Avedillo P, Rojo P, Fernández McPhee C, Benito A, Ramos JT, Holguín Á.

    HIV-1 variability and viral load technique could lead to false positive HIV-1 detection and to erroneous viral quantification in infected specimens.

    JOURNAL OF INFECTION . 71(3): 368-376. Number of citations: 15

    [doi:10.1016/j.jinf.2015.05.011]

  • Campos M, Llorens C, Sempere JM, Futami R, Rodriguez I, Carrasco P, Capilla R, Latorre A, Coque TM, Moya A, Baquero F.

    A membrane computing simulator of trans-hierarchical antibiotic resistance evolution dynamics in nested ecological compartments (ARES).

    BIOLOGY DIRECT . 10(1): 41-41. Number of citations: 14

    [doi:10.1186/s13062-015-0070-9]

  • Theuretzbacher U, Van Bambeke F, Cantón R, Giske CG, Mouton JW, Nation RL, Paul M, Turnidge JD, Kahlmeter G.

    Reviving old antibiotics

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY . 70(8): 2177-2181. Number of citations: 62

    [doi:10.1093/jac/dkv157]

  • Cabal A, Geue L, Gómez-Barrero S, Barth S, Bárcena C, Hamm K, Porrero MC, Valverde A, Cantón R, Menge C, Gortázar C, Domínguez L, Álvarez J.

    Detection of virulence-associated genes characteristic of intestinal Escherichia coli pathotypes, including the enterohemorrhagic/enteroaggregative O104:H4, in bovines from Germany and Spain

    MICROBIOLOGY AND IMMUNOLOGY . 59(8): 433-442. Number of citations: 11

    [doi:10.1111/1348-0421.12275]

  • Díez-Aguilar M, Morosini MI, López-Cerero L, Pascual Á, Calvo J, Martínez-Martínez L, Marco F, Vila J, Ortega A, Oteo J, Cantón R.

    Performance of EUCAST and CLSI approaches for co-amoxiclav susceptibility testing conditions for clinical categorization of a collection of Escherichia coli isolates with characterized resistance phenotypes

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY . 70(8): 2306-2310. Number of citations: 11

    [doi:10.1093/jac/dkv088]

  • Marcos-Zambrano LJ, Escribano P, Sanguinetti M, Gómez G de la Pedrosa E, De Carolis E, Vella A, Cantón R, Bouza E, Guinea J.

    Clusters of patients with candidaemia due to genotypes of Candida albicans and Candida parapsilosis: differences in frequency between hospitals

    CLINICAL MICROBIOLOGY AND INFECTION . 21(7): 677-683. Number of citations: 10

    [doi:10.1016/j.cmi.2015.03.007]

  • Roca I, Akova M, Baquero F, Carlet J, Cavaleri M, Coenen S, Cohen J, Findlay D, Gyssens I, Heure OE, Kahlmeter G, Kruse H, Laxminarayan R, Liébana E, López-Cerero L, MacGowan A, Martins M, Rodríguez-Baño J, Rolain JM, Segovia C, Sigauque B, Taconelli E, Wellington E, Vila J.

    The global threat of antimicrobial resistance: science for intervention.

    New microbes and new infections . 6: 22-29.

    [doi:10.1016/j.nmni.2015.02.007]

  • Fernández-Cooke E, Rojas P, Holguin A, Tomé MI, Jimenez de Ory S, Mellado MJ, Navarro ML, Rojo P, Ramos JT.

    Description and consequences of prescribing off-label antiretrovirals in the Madrid Cohort of HIV-infected children over a quarter of a century (1988-2012).

    ANTIVIRAL THERAPY . 21(1): 65-70. Number of citations: 4

    [doi:10.3851/IMP2973]

  • Torner N, Soldevila N, Garcia JJ, Launes C, Godoy P, Castilla J, Domínguez A.

    Effectiveness of non-pharmaceutical measures in preventing pediatric influenza: a case-control study

    Bmc Public Health . 15: 543-543. Number of citations: 15

    [doi:10.1186/s12889-015-1890-3]

  • Rojas Sánchez P, de Mulder M, Fernandez-Cooke E, Prieto L, Rojo P, Jiménez de Ory S, José Mellado M, Navarro M, Tomas Ramos J, Holguín Á, Madrid Cohort of HIV-Infected Children and Adolescents Integrated in the Paediat.

    Clinical and virologic follow-up in perinatally HIV-1-infected children and adolescents in Madrid with triple-class antiretroviral drug-resistant viruses.

    CLINICAL MICROBIOLOGY AND INFECTION . 21(6): . Number of citations: 7

    [doi:10.1016/j.cmi.2015.02.003]

  • Oteo J, Ortega A, Bartolomé R, Bou G, Conejo C, Fernández-Martínez M, González-López JJ, Martínez-García L, Martínez-Martínez L, Merino M, Miró E, Mora M, Navarro F, Oliver A, Pascual Á, Rodríguez-Baño J, Ruiz-Carrascoso G, Ruiz-Garbajosa P, Zamorano L, Bautista V, Pérez-Vázquez M, Campos J, GEIH-GEMARA (SEIMC) and REIPI.

    Prospective Multicenter Study of Carbapenemase-Producing Enterobacteriaceae from 83 Hospitals in Spain Reveals High In Vitro Susceptibility to Colistin and Meropenem

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY . 59(6): 3406-3412. Number of citations: 98

    [doi:10.1128/AAC.00086-15]

  • Rhee SY, Blanco JL, Jordan MR, Taylor J, Lemey P, Varghese V, Hamers RL, Bertagnolio S, de Wit TF, Aghokeng AF, Albert J, Avi R, Avila-Rios S, Bessong PO, Brooks JI, Boucher CA, Brumme ZL, Busch MP, Bussmann H, Chaix ML, Chin BS, D'Aquin TT, De Gascun CF, Derache A, Descamps D, Deshpande AK, Djoko CF, Eshleman SH, Fleury H, Frange P, Fujisaki S, Harrigan PR, Hattori J, Holguin A, Hunt GM, Ichimura H, Kaleebu P, Katzenstein D, Kiertiburanakul S, Kim JH, Kim SS, Li Y, Lutsar I, Morris L, Ndembi N, Kee PN, Paranjape RS, Peeters M, Poljak M, Price MA, Ragonnet-Cronin ML, Reyes-Terán G, Rolland M, Sirivichayakul S, Smith DM, Soares MA, Soriano VV, Ssemwanga D, Stanojevic M, Stefani MA, Sugiura W, Sungkanuparph S, Tanuri A, Tee KK, Truong HH, van de Vijver DA, Vidal N, Yang C, Yang R, Yebra G, Ioannidis JP, Vandamme AM, Shafer RW.

    Correction: Geographic and Temporal Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted HIV-1 Drug Resistance: An Individual-Patient- and Sequence-Level Meta-Analysis.

    PLOS MEDICINE . 12(6): .

    [doi:10.1371/journal.pmed.1001845]

  • Testa R, Cantón R, Giani T, Morosini MI, Nichols WW, Seifert H, Stefanik D, Rossolini GM, Nordmann P.

    In vitro activity of ceftazidime, ceftaroline and aztreonam alone and in combination with avibactam against European Gram-negative and Gram-positive clinical isolates

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS . 45(6): 641-646. Number of citations: 36

    [doi:10.1016/j.ijantimicag.2014.12.033]

  • Rodriguez-Dominguez M, Gonzalez-Alba JM, Puerta T, Menendez B, Sanchez-Diaz AM, Canton R, del Romero J, Galan JC.

    High Prevalence of Co-Infections by Invasive and Non-Invasive Chlamydia trachomatis Genotypes during the Lymphogranuloma Venereum Outbreak in Spain

    Plos One . 10(5): . Number of citations: 11

    [doi:10.1371/journal.pone.0126145]

  • Costa E, Rodríguez-Domínguez M, Clari MÁ, Giménez E, Galán JC, Navarro D.

    Comparison of the performance of 2 commercial multiplex PCR platforms for detection of respiratory viruses in upper and lower tract respiratory specimens

    DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE . 82(1): 40-43. Number of citations: 14

    [doi:10.1016/j.diagmicrobio.2015.02.004]

  • Rodríguez I, Novais Â, Lira F, Valverde A, Curião T, Martínez JL, Baquero F, Cantón R, Coque TM.

    Antibiotic-resistant Klebsiella pneumoniae and Escherichia coli high-risk clones and an IncFII(k) mosaic plasmid hosting Tn1 (blaTEM-4) in isolates from 1990 to 2004.

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY . 59(5): 2904-2908. Number of citations: 6

    [doi:10.1128/AAC.00296-15]