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Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

Search for publications

Only original articles, editorials, guidelines.

  • Levin BR, McCall IC, Perrot V, Weiss H, Ovesepian A, Baquero F.

    A Numbers Game: Ribosome Densities, Bacterial Growth, and Antibiotic-Mediated Stasis and Death.

    Mbio . 8(1): . Number of citations: 30

    [doi:10.1128/mBio.02253-16]

  • Grundmann H, Glasner C, Albiger B, Aanensen DM, Tomlinson CT, Andrasevic AT, Cantón R, Carmeli Y, Friedrich AW, Giske CG, Glupczynski Y, Gniadkowski M, Livermore DM, Nordmann P, Poirel L, Rossolini GM, Seifert H, Vatopoulos A, Walsh T, Woodford N, Monnet DL, European Survey of Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) Working.

    Occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in the European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE): a prospective, multinational study.

    LANCET INFECTIOUS DISEASES . 17(2): 153-163.

    [doi:10.1016/S1473-3099(16)30257-2]

  • Bordallo-Cardona MÁ, Escribano P, Gómez G de la Pedrosa E, Marcos-Zambrano LJ, Cantón R, Bouza E, Guinea J.

    In Vitro Exposure to Increasing Micafungin Concentrations Easily Promotes Echinocandin Resistance in Candida glabrata Isolates.

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY . 61(2): . Number of citations: 26

    [doi:10.1128/AAC.01542-16]

  • Cantón R, Livermore DM, Morosini MI, Díaz-Regañón J, Rossolini GM, PREMIUM Study Group.

    Etest® versus broth microdilution for ceftaroline MIC determination with Staphylococcus aureus: results from PREMIUM, a European multicentre study.

    The Journal of antimicrobial chemotherapy . 72(2): 431-436. Number of citations: 14

    [doi:10.1093/jac/dkw442]

  • Rodrigues C, Novais Â, Sousa C, Ramos H, Coque TM, Cantón R, Lopes JA, Peixe L.

    Elucidating constraints for differentiation of major human Klebsiella pneumoniae clones using MALDI-TOF MS.

    EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES . 36(2): 379-386. Number of citations: 12

    [doi:10.1007/s10096-016-2812-8]

  • Ponce-Alonso M, Del Campo R, Fortun J, Canton R, Morosini MI.

    First description of late recurrence of catheter-associated bacteraemia due to Cellulosimicrobium cellulans.

    ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA . 35(2): 131-133. Number of citations: 3

    [doi:10.1016/j.eimc.2016.05.003]

  • Lanza VF, Baquero F, de la Cruz F, Coque TM.

    AcCNET (Accessory Genome Constellation Network): comparative genomics software for accessory genome analysis using bipartite networks.

    Bioinformatics . 33(2): 283-285. Number of citations: 31

    [doi:10.1093/bioinformatics/btw601]

  • Cantón R, Díez-Aguilar M, Morosini MI.

    Puntos de corte de dalbavancina y recomendaciones para el estudio de su actividad in vitro.

    ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA . 35 Suppl 1: 15-21.

    [doi:10.1016/S0213-005X(17)30030-7]

  • Ellington MJ, Ekelund O, Aarestrup FM, Canton R, Doumith M, Giske C, Grundman H, Hasman H, Holden M, Hopkins KL, Iredell J, Kahlmeter G, Köser CU, MacGowan A, Mevius D, Mulvey M, Naas T, Peto T, Rolain JM, Samuelsen Ø, Woodford N.

    The role of whole genome sequencing in antimicrobial susceptibility testing of bacteria: report from the EUCAST Subcommittee.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases . 23(1): 2-22. Number of citations: 245

    [doi:10.1016/j.cmi.2016.11.012]

  • Martínez JL, Coque TM, Lanza VF, de la Cruz F, Baquero F.

    Genomic and metagenomic technologies to explore the antibiotic resistance mobilome.

    Annals of the New York Academy of Sciences . 1388(1): 26-41. Number of citations: 24

    [doi:10.1111/nyas.13282]

  • Alvarez P, Prieto L, Martín L, Obiang J, Avedillo P, Vargas A, Rojo P, Fernández McPhee C, Sanz Canalejas L, Benito A, Tomás Ramos J, Holguín Á.

    Evaluation of four commercial virological assays for early infant HIV-1 diagnosis using dried blood specimens.

    PEDIATRIC RESEARCH . 81(1-1): 80-87. Number of citations: 11

    [doi:10.1038/pr.2016.183]

  • Tedim AP, Ruíz-Garbajosa P, Rodríguez MC, Rodríguez-Baños M, Lanza VF, Derdoy L, Cárdenas Zurita G, Loza E, Cantón R, Baquero F, Coque TM.

    Long-term clonal dynamics of Enterococcus faecium strains causing bloodstream infections (1995-2015) in Spain.

    The Journal of antimicrobial chemotherapy . 72(1): 48-55. Number of citations: 18

    [doi:10.1093/jac/dkw366]

  • Herrera S, Sorlí L, Pérez-Sáez MJ, Ruiz-Garbajosa P, Barrios C, Plasencia V, Montero M, Terradas R, Crespo M, Castells X, Cantón R, Pascual J, Horcajada JP.

    Characterization and rapid control of a vancomycin-resistant Enterococcus faecium (VREF) outbreak in a renal transplant unit in Spain: The environment matters.

    ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA . 35(1): 5-11. Number of citations: 4

    [doi:10.1016/j.eimc.2016.04.002]

  • Pagán I, Rojas P, Ramos JT, Holguín Á.

    Clinical Determinants of HIV-1B Between-Host Evolution and their Association with Drug Resistance in Pediatric Patients.

    Plos One . 11(12): . Number of citations: 3

    [doi:10.1371/journal.pone.0167383]

  • García-Fernández S, Morosini MI, Cobo M, Foruny JR, López-Sanromán A, Cobo J, Romero J, Cantón R, Del Campo R.

    Gut eradication of VIM-1 producing ST9 Klebsiella oxytoca after fecal microbiota transplantation for diarrhea caused by a Clostridium difficile hypervirulent R027 strain.

    DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE . 86(4): 470-471. Number of citations: 19

    [doi:10.1016/j.diagmicrobio.2016.09.004]

  • Freitas AR, Tedim AP, Francia MV, Jensen LB, Novais C, Peixe L, Sánchez-Valenzuela A, Sundsfjord A, Hegstad K, Werner G, Sadowy E, Hammerum AM, Garcia-Migura L, Willems RJ, Baquero F, Coque TM.

    Multilevel population genetic analysis of vanA and vanB Enterococcus faecium causing nosocomial outbreaks in 27 countries (1986-2012).

    The Journal of antimicrobial chemotherapy . 71(12): 3351-3366. Number of citations: 91

    [doi:10.1093/jac/dkw312]

  • San Millan A, Escudero JA, Gifford DR, Mazel D, MacLean RC.

    Multicopy plasmids potentiate the evolution of antibiotic resistance in bacteria.

    Nature Ecology & Evolution . 1(1): 10-10. Number of citations: 76

    [doi:10.1038/s41559-016-0010]

  • Norman FF, Chamorro S, Vázquez A, Sánchez-Seco MP, Pérez-Molina JA, Monge-Maillo B, Vivancos MJ, Rodríguez-Dominguez M, Galán JC, de Ory F, López-Vélez R.

    Sequential Chikungunya and Zika Virus Infections in a Traveler from Honduras.

    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE . 95(5): 1166-1168. Number of citations: 15

    [doi:10.4269/ajtmh.16-0426]