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Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

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Only original articles, editorials, guidelines.

  • Duarte B, Pereira AP, Freitas AR, Coque TM, Hammerum AM, Hasman H, Antunes P, Peixe L, Novais C.

    Identification of 2CS-CHX T operon signature of chlorhexidine tolerance among Enterococcus faecium .

    APPLIED AND ENVIRONMENTAL MICROBIOLOGY . 85(23): . Number of citations: 4

    [doi:10.1128/AEM.01589-19]

  • Fonseca E Silva D, Silva-Dias A, Gomes R, Martins-Oliveira I, Ramos MH, Rodrigues AG, Cantón R, Pina-Vaz C.

    Evaluation of rapid colistin susceptibility directly from positive blood cultures using a flow cytometry assay.

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS . 54(6): 820-823. Number of citations: 13

    [doi:10.1016/j.ijantimicag.2019.08.016]

  • de Barrios O, Sanchez-Moral L, Cortés M, Ninfali C, Profitós-Pelejà N, Martínez-Campanario MC, Siles L, Del Campo R, Fernández-Aceñero MJ, Darling DS, Castells A, Maurel J, Salas A, Dean DC, Postigo A.

    ZEB1 promotes inflammation and progression towards inflammation-driven carcinoma through repression of the DNA repair glycosylase MPG in epithelial cells.

    Gut . 68(12): 2129-2141. Number of citations: 15

    [doi:10.1136/gutjnl-2018-317294]

  • Kissling, Esther, Pozo, Francisco, Buda, Silke, Vilcu, Ana-Maria, Gherasim, Alin, Brytting, Mia, Domegan, Lisa, Gomez, Veronica, Meijer, Adam, Lazar, Mihaela, Vucina, Vesna Visekruna, Duerrwald, Ralf, van der Werf, Sylvie, Larrauri, Amparo, Enkirch, Theresa, O'Donnell, Joan, Guiomar, Raquel, Hooiveld, Mariette, Petrovic, Goranka, Stoian, Elena, Penttinen, Pasi, Valenciano, Marta, Preuss, Ute, Tolksdorf, Kristin, Biere, Barbara, Smallfield, Maria, Wedde, Marianne, Falchi, Alessandra, Masse, Shirley, Villechenaud, Natacha, Souty, Cecile, Blanchon, Thierry, Launay, Titouan, Enouf, Vincent, Behillil, Sylvie, Lina, Bruno, Valette, Martine, Mazagatos, Clara, Casas, Inmaculada, Garcia Comas, Luis, Insua Marisquerena, Maria Esther, Carlos Galan, Juan, Castilla, Jesus, Garcia Cenoz, Manuel, Navascues, Ana, Quinones Rubio, Carmen, Ibanez Perez, Ana Carmen, Martinez Ochoa, Eva, Blasco, Miriam, Gimenez Duran, Jaume, Maria Vanrell, Juana, Reina, Jordi, Castrillejo, Daniel, Wiman, Asa, Hunt, Meadhbh, Joyce, Michael, Levis, Olga, Collins, Claire, Dunford, Linda, Bennett, Charlene, Moran, Joanne, Tuite, Grainne, Connell, Jeff, de Gascun, Cillian, Rodrigues, Ana Paula, Machado, Ausenda, Nunes, Baltazar, Kislaya, Irina, Costa, Ines, Conde, Patricia, Cristovao, Paula, Pechirra, Pedro, Borges, Vitor, Bagheri, Mariam, van den Brink, Sharon, Dijkstra, Frederika, Goderski, Gabriel, van der Hoek, Wim, de Lange, Marit, Marzec, Ton, Overduin, Pieter, Reukers, Daphne, Teirlinck, Anne, Wijsman, Lisa, Donker, Ge, Mihai, Maria Elena, Cherciu, Carmen Maria, Alexandrescu, Viorel, Kaic, Bernard, Filipovic, Sanja Kurecic, Novosel, Iva Pem, Makaric, Zvjezdana Lovric, Zajec, Martina, Drazenovic, Vladimir, Moren, Alain, I-MOVE Primary Care Study Team.

    Low 2018/19 vaccine effectiveness against influenza A(H3N2) among 15-64-year-olds in Europe: exploration by birth cohort

    Eurosurveillance . 24(48): 31-42. Number of citations: 20

    [doi:10.2807/1560-7917.ES.2019.24.48.1900604]

  • Zorita-Garcia, Mario, Oscar Alonso-Ezpeleta, Luis, Cobo, Marta, del Campo, Rosa, Rico-Romano, Cristina, Mena-Alvarez, Jesus, Zubizarreta-Macho, Alvaro.

    Photodynamic therapy in endodontic root canal treatment significantly increases bacterial clearance, preventing apical periodontitis

    QUINTESSENCE INTERNATIONAL . 50(10): 782-789. Number of citations: 8

    [doi:10.3290/j.qi.a43249]

  • Bayjanov JR, Ekkelenkamp MB, Rogers MR, Cantón R, Benaissa-Trouw BJ, Díez-Aguilar M, Tunney M, Fluit AC.

    Whole genome analysis of Pandoraea species strains from cystic fibrosis patients.

    Future Microbiology . 14(16): 1357-1367. Number of citations: 2

    [doi:10.2217/fmb-2019-0038]

  • Waters VJ, Kidd TJ, Canton R, Ekkelenkamp MB, Johansen HK, LiPuma JJ, Bell SC, Elborn JS, Flume PA, VanDevanter DR, Gilligan P, Antimicrobial Resistance International Working Group in Cystic Fibrosis.

    Reconciling Antimicrobial Susceptibility Testing and Clinical Response in Antimicrobial Treatment of Chronic Cystic Fibrosis Lung Infections.

    CLINICAL INFECTIOUS DISEASES . 69(10): 1812-1816. Number of citations: 31

    [doi:10.1093/cid/ciz364]

  • Baquero F, Lanza VF, Baquero MR, Del Campo R, Bravo-Vázquez DA.

    Microcins in Enterobacteriaceae : Peptide Antimicrobials in the Eco-Active Intestinal Chemosphere.

    FRONTIERS IN MICROBIOLOGY . 10: 2261-2261. Number of citations: 43

    [doi:10.3389/fmicb.2019.02261]

  • López Y, Tato M, Gargallo-Viola D, Cantón R, Vila J, Zsolt I.

    Mutant prevention concentration of ozenoxacin for quinolone-susceptible or -resistant Staphylococcus aureus and Staphylococcus epidermidis.

    Plos One . 14(10): 223326-223326. Number of citations: 8

    [doi:10.1371/journal.pone.0223326]

  • Machuca, Isabel, Gutierrez-Gutierrez, Belen, Rivera-Espinar, Francisco, Cano, Angela, Gracia-Ahufinger, Irene, Guzman-Puche, Julia, Marfil-Perez, Eduardo, Perez-Nadales, Elena, Jose Caston, Juan, Bonomo, Robert A., Carmeli, Yehuda, Paterson, David, Pascual, Alvaro, Martinez-Martinez, Luis, Rodriguez-Bano, Jesus, Torre-Cisneros, Julian, Salamanca, E., de Cueto, M., Hsueh, P. -R., Viale, P., Bartoletti, M., Giannella, M., Pano-Pardo, J. R., Mora-Rillo, M., Navarro-San Francisco, C., Venditti, M., Falcone, M., Russo, A., Tumbarello, M., Trecarichi, E. M., Losito, A. R., Daikos, G., Skiada, A., Canton, R., Pintado, V., Ruiz, P., Doi, Y., Tuon, F. F., Karaiskos, I., Giamarellou, H., Schwaber, M. J., Azap, O. K., Souli, M., Antoniadou, A., Poulakou, G., Roilides, E., Iosifidis, E., Pournaras, S., Tsakris, A., Zarkotou, O., Akova, M., Helvaci, O., Sahin, A. O., Perez, F., Bermejo, J., Rucci, V., Oliver, A., Ruiz de Gopegui, E., Marinescu, C. I., de la Calle, C., Martinez, J. A., Morata, L., Soriano, A., Lowman, W., Almirante, B., Larrosa, N., Puig-Asensio, M., Garcia-Vazquez, E., Hernandez, A., Gomez, J., Bou, G., Prim, N., Navarro, F., Mirelis, B., Origuen, J., San Juan, R., Fernandez-Ruiz, M., Cisneros, J. M., Molina, J., Gonzalez, V., Farinas, M. C., Cano, M. E., Gozalo, M., Pena, C., Gomez-Zorrilla, S., Tubau, F., Pitout, J., Virmani, D., Natera, C., Marfil, E., Tacconelli, E., Riemenschneider, F., Calbo, E., Badia, C., Xercavins, M., Gasch, O., Fontanals, D., Jove, E., REIPI ESGBIS INCREMENT Grp.

    External validation of the INCREMENT-CPE mortality score in a carbapenem-resistant Klebsiella pneumoniae bacteraemia cohort: the prognostic significance of colistin resistance

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS . 54(4): 442-448. Number of citations: 6

    [doi:10.1016/j.ijantimicag.2019.07.017]

  • Hernández-García M, Pérez-Viso B, Navarro-San Francisco C, Baquero F, Morosini MI, Ruiz-Garbajosa P, Cantón R.

    Intestinal co-colonization with different carbapenemase-producing Enterobacterales isolates is not a rare event in an OXA-48 endemic area.

    Eclinicalmedicine . 15: 72-79. Number of citations: 15

    [doi:10.1016/j.eclinm.2019.09.005]

  • Piñeiro L, Galán JC, Vall-Mayans M.

    Infections caused by Chlamydia trachomatis (including lymphogranuloma venereum) and Mycoplasma genitalium.

    ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA . 37(8): 525-534. Number of citations: 2

    [doi:10.1016/j.eimc.2019.01.014]

  • Palacios-Baena ZR, Delgado-Valverde M, Valiente Méndez A, Almirante B, Gómez-Zorrilla S, Borrell N, Corzo JE, Gurguí M, de la Calle C, García-Álvarez L, Ramos L, Gozalo M, Morosini MI, Molina J, Causse M, Pascual Á, Rodríguez-Baño J, REIPI/GEIRAS-SEIMC BACTERIEMIA-MIC group.

    Impact of de-escalation on prognosis of patients with bacteraemia due to Enterobacteriaceae: a post-hoc analysis from a multicenter prospective cohort.

    CLINICAL INFECTIOUS DISEASES . 69(6): 956-962. Number of citations: 11

    [doi:10.1093/cid/ciy1032]

  • MacLean RC, San Millan A.

    The evolution of antibiotic resistance.

    Science . 365(6458): 1082-1083. Number of citations: 94

    [doi:10.1126/science.aax3879]

  • Gomez-Sala, Beatriz, Munoz-Atienza, Estefania, Diep, Dzung B., Feito, Javier, del Campo, Rosa, Nes, Ingolf F., Herranz, Carmen, Hernandez, Pablo E., Cintas, Luis M..

    Biotechnological potential and in vitro safety assessment of Lactobacillus curvatus BCS35, a multibacteriocinogenic strain isolated from dry-salted cod (Gadus morhua)

    LWT-FOOD SCIENCE AND TECHNOLOGY . 112: . Number of citations: 1

    [doi:10.1016/j.lwt.2019.05.117]

  • Sánchez-López J, Cantón R.

    Current status of ESKAPE microorganisms in Spain: Epidemiology and resistance phenotypes.

    REVISTA ESPANOLA DE QUIMIOTERAPIA . 32 Suppl 2: 27-31. Number of citations: 7

  • Hernando-Amado S, Coque TM, Baquero F, Martínez JL.

    Defining and combating antibiotic resistance from One Health and Global Health perspectives.

    Nature Microbiology . 4(9): 1432-1442. Number of citations: 256

    [doi:10.1038/s41564-019-0503-9]

  • Morosini MI, Díez-Aguilar M, Cantón R.

    Mechanisms of action and antimicrobial activity of ceftobiprole.

    REVISTA ESPANOLA DE QUIMIOTERAPIA . 32 Suppl 3: 3-10. Number of citations: 15