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Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

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Only original articles, editorials, guidelines.

  • Calvo-Lerma J, Hulst J, Boon M, Colombo C, Masip E, Ruperto M, Fornés-Ferrer V, van der Wiel E, Claes I, Garriga M, Roca M, Crespo-Escobar P, Bulfamante A, Woodcock S, Martínez-Barona S, Andrés A, de Boeck K, Ribes-Koninckx C, MyCyFAPP project.

    Clinical validation of an evidence-based method to adjust Pancreatic Enzyme Replacement Therapy through a prospective interventional study in paediatric patients with Cystic Fibrosis.

    Plos One . 14(3): . Number of citations: 6

    [doi:10.1371/journal.pone.0213216]

  • Moreno EC, Pascual A, Prieto-Cuadra D, Laza VF, Molina-Cerrillo J, Ramos-Muñoz ME, Rodríguez-Serrano EM, Soto JL, Carrato A, García-Bermejo ML, Guillén-Ponce C.

    Novel Molecular Characterization of Colorectal Primary Tumors Based on miRNAs.

    Cancers . 11(3): . Number of citations: 19

    [doi:10.3390/cancers11030346]

  • Villar J, Ambrós A, Mosteiro F, Martínez D, Fernández L, Ferrando C, Carriedo D, Soler JA, Parrilla D, Hernández M, Andaluz-Ojeda D, Añón JM, Vidal A, González-Higueras E, Martín-Rodríguez C, Díaz-Lamas AM, Blanco J, Belda J, Díaz-Domínguez FJ, Rico-Feijoó J, Martín-Delgado C, Romera MA, González-Martín JM, Fernández RL, Kacmarek RM.

    A Prognostic Enrichment Strategy for Selection of Patients With Acute Respiratory Distress Syndrome in Clinical Trials.

    CRITICAL CARE MEDICINE . 47(3): 377-385. Number of citations: 7

    [doi:10.1097/CCM.0000000000003624]

  • Castanheira M, Deshpande LM, Mendes RE, Canton R, Sader HS, Jones RN.

    Variations in the Occurrence of Resistance Phenotypes and Carbapenemase Genes Among Enterobacteriaceae Isolates in 20 Years of the SENTRY Antimicrobial Surveillance Program.

    Open forum infectious diseases . 6(Suppl 1): 23-33. Number of citations: 77

    [doi:10.1093/ofid/ofy347]

  • Díaz-Agero Pérez C, López-Fresneña N, Rincon Carlavilla AL, Hernandez Garcia M, Ruiz-Garbajosa P, Aranaz-Andrés JM, Maechler F, Gastmeier P, Bonten MJM, Canton R.

    Local prevalence of extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae intestinal carriers at admission and co-expression of ESBL and OXA-48 carbapenemase in Klebsiella pneumoniae : a prevalence survey in a Spanish University Hospital.

    BMJ open . 9(3): . Number of citations: 16

    [doi:10.1136/bmjopen-2018-024879]

  • Vila J, Hebert AA, Torrelo A, López Y, Tato M, García-Castillo M, Cantón R.

    Ozenoxacin: a review of preclinical and clinical efficacy.

    EXPERT REVIEW OF ANTI-INFECTIVE THERAPY . 17(3): 1-10. Number of citations: 21

    [doi:10.1080/14787210.2019.1573671]

  • Delhaes L, Touati K, Faure-Cognet O, Cornet M, Botterel F, DannaouiI E, Morio F, Le Pape P, Grenouillet F, Favennec L, Le Gal S, Nevez G, Duhamel A, Borman A, Saegeman V, Lagrou K, Gomez E, Carro ML, Canton R, Campana S, Buzina W, Chen S, Meyer W, Roilides E, Simitsopoulou M, Manso E, Cariani L, Biffi A, Fiscarelli E, Ricciotti G, Pihet M, Bouchara JP.

    Prevalence, geographic risk factor, and development of a standardized protocol for fungal isolation in cystic fibrosis: Results from the international prospective study MFIP.

    JOURNAL OF CYSTIC FIBROSIS . 18(2): 212-220. Number of citations: 25

    [doi:10.1016/j.jcf.2018.10.001]

  • Costa-Alcalde JJ, Barbeito-Castiñeiras G, González-Alba JM, Aguilera A, Galán JC, Pérez-Del-Molino ML.

    Comparative evaluation of the identification of rapidly growing non-tuberculous mycobacteria by mass spectrometry (MALDI-TOF MS), GenoType Mycobacterium CM/AS assay and partial sequencing of the rpoß gene with phylogenetic analysis as a reference method.

    ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA . 37(3): 160-166. Number of citations: 4

    [doi:10.1016/j.eimc.2018.04.012]

  • Filipovic, Sanja Kurecic, Visekruna-Vucina, Vesna, Novosel, Iva Pem, Lovric, Zvjezdana, Petrovic, Goranka, Drazenovic, Vladimir, Vince, Adriana, Topic, Antea, Mihalic, Jelena Budimir, Huljev, Eva, Luksic, Boris, Karabuva, Svjetlana, Cikes, Mihaela, Emborg, Hanne-Dorthe, Trebbien, Ramona, Helmuth, Ida Glode, Krause, Tyra Grove, Lina, Bruno, Falchi, Alessandra, Vilcu, Ana-Maria, Souty, Cecile, Blanchon, Thierry, Launay, Titouan, van der Werf, Sylvie, Enouf, Vincent, Behillil, Sylvie, Valette, Martine, Launay, Odile, Lachatre, Marie, Lenzi, Nezha, L'Honneur, Anne-Sophie, Galtier, Florence, Olivier, Gaget Olivier, Foulongne, Vincent, Merle, Corinne, Vanhems, Philippe, Laine, Fabrice, Lagathu, Gisele, Carrat, Fabrice, Valenciano, Marta, Kissling, Esther, Rose, Angela, Penttinen, Pasi, Buda, Silke, Preuss, Ute, Tolksdorf, Kristin, Biere, Barbara, Duerrwald, Ralf, Smallfield, Maria, Wedde, Marianne, Domegan, Lisa, Hunt, Meadhbh, O'Donnell, Joan, Joyce, Michael, Levis, Olga, Collins, Claire, Dunford, Linda, Moran, Joanne, Tuite, Grainne, Connell, Jeff, de Gascun, Cillian, Casado, Itziar, Fernandino, Leticia, Martinez-Baz, Ivan, Juanbeltz, Regna, Ibanez, Carlos Gomez, Aguinaga, Aitziber, Ezpeleta, Carmen, Meijer, Adam, van der Hoek, Wim, Bagheri, Mariam, van den Brink, Sharon, Dijkstra, Frederika, Goderski, Gabriel, de lange, Marit, Marzec, Ton, Overduin, Pieter, Poorter, Elsa, Reukers, Daphne, Teirlinck, Anne Carola, Wijsman, Lisa, Donker, Ge, Hooiveld, Mariette, Gomez, Veronica, Kislaya, Irina, Machado, Ausenda, Nunes, Baltazar, Paula Rodrigues, Ana, Conde, Patricia, Costa, Ines, Cristovao, Paula, Guiomar, Raquel, Pechirra, Pedro, Lazar, Mihaela, Cherciu, Carmen Maria, Mihai, Maria Elena, Stoian, Elena, Dragomirescu, Cerasella, Popa, Mircea Ioan, Juganariu, Gabriela, Gradinaru, Maria, Loghin, Izabela, Vlad, Liliana, Duca, Elena, Hurmuzache, Mihnea, Dorobat, Carmen, Tardei, Gratela, Melinte, Violeta, Zaharia, Mihaela, Popescu, Corneliu Petru, Ceausu, Emanoil, Florescu, Simin-Aysel, Gherasim, Alin, Garcia Comas, Luis, Insua Marisquerena, Maria Esther, Galan, Juan Carlos, Dolores Folgueira, Ma, Castilla, Jesus, Garcia Cenoz, Manuel, Navascues, Ana, Quinones Rubio, Carmen, Martinez Ochoa, Eva, Blasco, Miriam, Gimenez Duran, Jaume, Maria Vanrell, Juana, Reina, Jordi, Castrillejo, Daniel, Delgado, Concha, Oliva, Jesus, Larrauri, Amparo, Gherasim, Alin Manuel, Mazagatos, Clara, Pozo, Francisco, Casas, Inmaculada, Latorre, Miriam, Millan Lou, Maria Isabel, Maria Milagro, Ana, Aizpurua, Amaia, Cilla, Gustavo, Montes, Milagrosa, Brytting, Mia, Enkirch, Theresa, Carnahan, Annasara, Wiman, Asa, Pebody, Richard, Whitaker, Heather, Andrews, Nick, Ellis, Joanna, Marques, Diogo F. P., Cottrell, Simon, Reynolds, Arlene, Gunson, Rory, Shepherd, Samantha J., Thompson, Catherine, Galiano, Monica, Robertson, Chris, O'Doherty, Mark, Owens, Katie, Yonova, Ivelina, Moore, Catherine, Johnson, Jillian, de Lusignan, Simon, McMenamin, Jim, Zambon, Maria, European IVE Grp.

    Interim 2018/19 influenza vaccine effectiveness: six European studies, October 2018 to January 2019

    Eurosurveillance . 24(8): 2-14. Number of citations: 37

    [doi:10.2807/1560-7917.ES.2019.24.1900121]

  • Hemelaar J, Elangovan R, Yun J, Dickson-Tetteh L, Fleminger I, Kirtley S, Williams B, Gouws-Williams E, Ghys PD, WHO–UNAIDS Network for HIV Isolation Characterisation.

    Global and regional molecular epidemiology of HIV-1, 1990-2015: a systematic review, global survey, and trend analysis.

    The Lancet. Infectious diseases . 19(2): 143-155. Number of citations: 132

    [doi:10.1016/S1473-3099(18)30647-9]

  • Abodakpi H, Chang KT, Gao S, Sánchez-Díaz AM, Cantón R, Tam VH.

    Optimal Piperacillin-Tazobactam Dosing Strategies against Extended-Spectrum--Lactamase-Producing Enterobacteriaceae .

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY . 63(2): . Number of citations: 6

    [doi:10.1128/AAC.01906-18]

  • Barragán-Prada H, Ruiz-Hueso P, Tedim AP, González-Candelas F, Galán JC, Cantón R, Morosini MI.

    Emergence and dissemination of colistin-resistant Klebsiella pneumoniae isolates expressing OXA-48 plus CTX-M-15 in patients not previously treated with colistin in a Spanish university hospital.

    DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE . 93(2): 147-153. Number of citations: 3

    [doi:10.1016/j.diagmicrobio.2018.08.014]

  • Campos M, Capilla R, Naya F, Futami R, Coque T, Moya A, Fernandez-Lanza V, Cantón R, Sempere JM, Llorens C, Baquero F.

    Simulating Multilevel Dynamics of Antimicrobial Resistance in a Membrane Computing Model.

    Mbio . 10(1): . Number of citations: 17

    [doi:10.1128/mBio.02460-18]

  • Aravena C, Valencia B, Villegas A, Ortega M, Fernández R A, Araya R P, Saavedra A, del Campo R.

    Caracterización de cepas clínicas y ambientales de Salmonella enterica subsp. enterica serovar Heidelberg aisladas en Chile.

    REVISTA MEDICA DE CHILE . 147(1): 24-33. Number of citations: 3

    [doi:10.4067/S0034-98872019000100024]

  • Del Campo R, Martínez-García L, Sánchez-Díaz AM, Baquero F.

    Biology of Hand-to-Hand Bacterial Transmission.

    Microbiology spectrum . 7(1): . Number of citations: 4

    [doi:10.1128/microbiolspec.MTBP-0011-2016]

  • Ruppé E, Ghozlane A, Tap J, Pons N, Alvarez AS, Maziers N, Cuesta T, Hernando-Amado S, Clares I, Martínez JL, Coque TM, Baquero F, Lanza VF, Máiz L, Goulenok T, de Lastours V, Amor N, Fantin B, Wieder I, Andremont A, van Schaik W, Rogers M, Zhang X, Willems RJL, de Brevern AG, Batto JM, Blottière HM, Léonard P, Léjard V, Letur A, Levenez F, Weiszer K, Haimet F, Doré J, Kennedy SP, Ehrlich SD.

    Prediction of the intestinal resistome by a three-dimensional structure-based method.

    Nature Microbiology . 4(1): 112-123. Number of citations: 67

    [doi:10.1038/s41564-018-0292-6]

  • Pastor Ó, Guzmán-Lafuente P, Serna J, Muñoz-Hernández M, López Neyra A, García-Rozas P, García-Seisdedos D, Alcázar A, Lasunción MA, Busto R, Lamas Ferreiro A.

    A comprehensive evaluation of omega-3 fatty acid supplementation in cystic fibrosis patients using lipidomics.

    JOURNAL OF NUTRITIONAL BIOCHEMISTRY . 63: 197-205. Number of citations: 7

    [doi:10.1016/j.jnutbio.2018.09.026]

  • Díez-Aguilar M, Ekkelenkamp M, Morosini MI, Merino I, Caballero JD, Jones M, van Westreenen M, Tunney MM, Cantón R, Fluit AC.

    Antimicrobial susceptibility of non-fermenting Gram-negative pathogens isolated from cystic fibrosis patients.

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS . 53(1): 84-88. Number of citations: 15

    [doi:10.1016/j.ijantimicag.2018.09.001]