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Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

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Only original articles, editorials, guidelines.

  • Andersson DI, Balaban NQ, Baquero F, Courvalin P, Glaser P, Gophna U, Kishony R, Molin S, Tønjum T.

    Antibiotic resistance: turning evolutionary principles into clinical reality.

    FEMS MICROBIOLOGY REVIEWS . 44(2): 171-188. Number of citations: 90

    [doi:10.1093/femsre/fuaa001]

  • Garcia-Fernandez, Sergio, Garcia-Castillo, Maria, Melo-Cristino, Jose, Pinto, Margarida F., Gonçalves E, Alves, Valquiria, Vieira AR, Ramalheira, Elmano, Sancho, Luisa, Diogo, Jose, Ferreira, Rui, Silva, Daniela, Chaves, Catarina, Passaro, Leonor, Paixão L, Canton, Rafael, STEP Study Group.

    In vitro activity of ceftolozane-tazobactam against Enterobacterales and Pseudomonas aeruginosa causing urinary, intra-abdominal and lower respiratory tract infections in intensive care units in Portugal: The STEP multicenter study

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS . 55(3): 105887-105887. Number of citations: 13

    [doi:10.1016/j.ijantimicag.2020.105887]

  • Moles, Laura, Gomez, Marta, Moroder, Elena, Bustos, Gerardo, Melgar, Ana, del Campo, Rosa, Rodriguez, Juan M..

    Staphylococcus epidermidis in feedings and feces of preterm neonates

    Plos One . 15(2): . Number of citations: 7

    [doi:10.1371/journal.pone.0227823]

  • Schell, Celia M., Tedim, Ana P., Rodriguez-Banos, Mercedes, Sparo, Monica D., Lissarrague, Sabina, Basualdo, Juan A., Coque, Teresa M..

    Detection of beta-Lactamase-Producing Enterococcus faecalis and Vancomycin-Resistant Enterococcus faecium Isolates in Human Invasive Infections in the Public Hospital of Tandil, Argentina

    PATHOGENS . 9(2): . Number of citations: 4

    [doi:10.3390/pathogens9020142]

  • Ekkelenkamp, Miquel B., Canton, Rafael, Diez-Aguilar, Maria, Tunney, Michael M., Gilpin, Deirdre F., Bernardini, Francesca, Dale, Glenn E., Elborn, J. Stuart, Bayjanov, Jumamurat R., Fluit, Ad.

    Susceptibility of Pseudomonas aeruginosa Recovered from Cystic Fibrosis Patients to Murepavadin and 13 Comparator Antibiotics

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY . 64(2): . Number of citations: 18

    [doi:10.1128/AAC.01541-19]

  • Garcia-Fernandez, Sergio, Bala, Yohann, Armstrong, Tom, Garcia-Castillo, Maria, Burnham, Carey-Ann D., Wallace, Meghan A., Hardy, Dwight, Zambardi, Gilles, Canton, Rafael.

    Multicenter Evaluation of the New Etest Gradient Diffusion Method for Piperacillin-Tazobactam Susceptibility Testing of Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii Complex

    JOURNAL OF CLINICAL MICROBIOLOGY . 58(2): . Number of citations: 12

    [doi:10.1128/JCM.01042-19]

  • Rodriguez-Rojas, Lourdes, Suarez-Lopez, Amaya, Canton, Rafael, Ruiz-Garbajosa, Patricia.

    Eikenella corrodens causing deep-seated infections. Six-year experience in a University Hospital in Madrid

    ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA . 38(2): 76-78. Number of citations: 7

    [doi:10.1016/j.eimc.2019.04.004]

  • Larrosa MN, Benito, Natividad, Canton, Rafael, Canut, Andres, Cercenado, Emilia, Fernandez-Cuenca, Felipe, Guinea, Jesus, Lopez-Navas, Antonio, Moreno MÁ, Oliver, Antonio, Martinez-Martinez, Luis.

    From CLSI to EUCAST, a necessary step in Spanish laboratories

    ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA . 38(2): 79-83. Number of citations: 7

    [doi:10.1016/j.eimc.2018.09.014]

  • Quiñones D, Aung MS, Carmona Y, González MK, Pereda N, Hidalgo M, Rivero M, Zayas A, del Campo R, Urushibara N, Kobayashi N.

    High Prevalence of CTX-M Type Extended-Spectrum Beta-Lactamase Genes and Detection of NDM-1 Carbapenemase Gene in Extraintestinal Pathogenic Escherichia coli in Cuba.

    PATHOGENS . 9(1): . Number of citations: 14

    [doi:10.3390/pathogens9010065]

  • Fluit, Ad C., Rogers MRC, Diez-Aguilar, Maria, Canton, Rafael, Benaissa-Trouw, Barry J., Bayjanov, Jumamurat R., Ekkelenkamp, Miquel B..

    Draft genome sequence of the strain 16-537536, isolated from a patient with bronchiectasis and its relationship to the Pseudomonas koreensis group of the Pseudomonas fluorescens complex

    BMC research notes . 13(1): 10-10.

    [doi:10.1186/s13104-019-4863-2]

  • Roqué M, Martínez-García L, Solà I, Alonso-Coello P, Bonfill X, Zamora J.

    Toolkit of methodological resources to conduct systematic reviews.

    F1000Research . 9: 82-82. Number of citations: 8

    [doi:10.12688/f1000research.22032.3]

  • Kluytmans, J., Voss, A., Kahlmeter, G., Giske, C., MacGowan, A., Brown, D., Gatermann, S., Lina, G., Lindemann, C., Turnidge, J., Canton, R., Petinaki, E., Vaz, C. Pina, Rodriguez Bano, J..

    Obituary: Johan Willem Mouton

    CLINICAL MICROBIOLOGY AND INFECTION . 26(1): 125-126. Number of citations: 2

    [doi:10.1016/j.cmi.2019.11.002]

  • Vivancos-Gallego, Maria J., Okhai, Hajra, Perez-Elias, Maria J., Gomez-Ayerbe, Cristina, Moreno-Zamora, Ana, Casado, Jose L., Quereda, Carmen, Sanz JM, Sanchez-Conde, Matilde, Serrano-Villar, Sergio, Del Campo, Santos, Dronda, Fernando, Galan JC, Sabin, Caroline A., Moreno, Santiago.

    CD4(+):CD8(+) T-cell ratio changes in people with HIV receiving antiretroviral treatment

    ANTIVIRAL THERAPY . 25(2): 91-100. Number of citations: 4

    [doi:10.3851/IMP3354]

  • Merino, Irene, Porter, Stephen B., Johnston, Brian, Clabots, Connie, Thuras, Paul, Ruiz-Garbajosa, Patricia, Canton, Rafael, Johnson, James R..

    Molecularly defined extraintestinal pathogenic Escherichia coli status predicts virulence in a murine sepsis model better than does virotype, individual virulence genes, or clonal subset among E. coli ST131 isolates

    Virulence . 11(1): 327-336. Number of citations: 12

    [doi:10.1080/21505594.2020.1747799]

  • Freitas, Ana R, Tedim, Ana P, Novais, Carla, Lanza, Val F, Peixe, Luisa.

    Comparative genomics of global optrA-carrying Enterococcus faecalis uncovers a common chromosomal hotspot for optrA acquisition within a diversity of core and accessory genomes.

    Microbial genomics . 6(6): . Number of citations: 31

    [doi:10.1099/mgen.0.000350]

  • Montealegre, Maria Camila, Talavera Rodriguez, Alba, Roy, Subarna, Hossain, Muhammed Iqbal, Islam, Mohammad Aminul, Lanza, Val F., Julian, Timothy R..

    High Genomic Diversity and Heterogenous Origins of Pathogenic and Antibiotic-Resistant Escherichia coli in Household Settings Represent a Challenge to Reducing Transmission in Low-Income Settings

    mSphere . 5(1): . Number of citations: 19

    [doi:10.1128/mSphere.00704-19]

  • Freitas, Ana R., Novais, Carla, Peixe, Luisa, Coque, Teresa M..

    Isolation and Visualization of Plasmids from Gram-Positive Bacteria of Interest in Public Health

    Methods in molecular biology (Clifton, N.J.) . 2075: 21-38. Number of citations: 1

    [doi:10.1007/978-1-4939-9877-7_2]

  • Novais, Carla, Freitas, Ana R., Leon-Sampedro, Ricardo, Peixe, Luisa, Coque, Teresa M..

    Methods to Quantify DNA Transfer in Enterococcus

    Methods in molecular biology (Clifton, N.J.) . 2075: 111-122. Number of citations: 1

    [doi:10.1007/978-1-4939-9877-7_8]