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Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

Search for publications

Only original articles, editorials, guidelines.

  • Viedma E, Dahdouh E, González-Alba JM, González-Bodi S, Martínez-García L, Lázaro-Perona F, Recio R, Rodríguez-Tejedor M, Folgueira MD, Cantón R, Delgado R, García-Rodríguez J, Galán JC, Mingorance J, On Behalf Of The Sars-CoV-Working Groups.

    Genomic Epidemiology of SARS-CoV-2 in Madrid, Spain, during the First Wave of the Pandemic: Fast Spread and Early Dominance by D614G Variants

    Microorganisms . 9(2): . Number of citations: 8

    [doi:10.3390/microorganisms9020454]

  • Troyano-Hernaez, Paloma, Reinosa, Roberto, Holguin, Africa.

    Evolution of SARS-CoV-2 Envelope, Membrane, Nucleocapsid, and Spike Structural Proteins from the Beginning of the Pandemic to September 2020: A Global and Regional Approach by Epidemiological Week

    VIRUSES-BASEL . 13(2): . Number of citations: 52

    [doi:10.3390/v13020243]

  • Garcia Garcia de Paredes A, Manicardi, Nicolo, Tellez, Luis, Ibañez L, Royo, Felix, Bermejo, Javier, Blanco, Carolina, Fondevila, Constantino, Fernandez Lanza, Val, Garcia-Bermejo, Laura, Falcon-Perez JM, Bañares R, Gracia-Sancho, Jordi, Albillos, Agustin.

    Molecular Profiling of Decompensated Cirrhosis by a Novel MicroRNA Signature

    Hepatology Communications . 5(2): 309-322. Number of citations: 10

    [doi:10.1002/hep4.1642]

  • Ponce-Alonso, Manuel, de la Fuente, Javier Saez, Rincon-Carlavilla, Angela, Moreno-Nunez, Paloma, Martinez-Garcia, Laura, Escudero-Sanchez, Rosa, Pintor, Rosario, Garcia-Fernandez, Sergio, Cobo, Javier.

    Impact of the coronavirus disease 2019 (COVID-19) pandemic on nosocomial Clostridioides difficile infection (Sept, 10.1017/ice.2020.454, 2020)

    INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY . 42(2): 250-250. Number of citations: 2

    [doi:10.1017/ice.2020.1380]

  • Hernandez-Garcia, Marta, Garcia-Fernandez, Sergio, Garcia-Castillo, Maria, Melo-Cristino, Jose, Pinto, Margarida F., Gonçalves E, Alves, Valquiria, Costa, Eliana, Ramalheira, Elmano, Sancho, Luisa, Diogo, Jose, Ferreira, Rui, Silva, Tania, Chaves, Catarina, Passaro, Leonor, Paixão L, Romano, Joao, Canton, Rafael, STEP study group.

    Confronting Ceftolozane-Tazobactam Susceptibility in Multidrug-Resistant Enterobacterales Isolates and Whole-Genome Sequencing Results (STEP Study)

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS . 57(2): 106259-106259. Number of citations: 7

    [doi:10.1016/j.ijantimicag.2020.106259]

  • López-Roa P, Martin-Higuera C, Ruiz-Serrano MJ, Toro C, Tato M, Simon M, Domingo D, Esteban J.

    Performance of Xpert MTB/RIF Ultra assay on respiratory and extra-respiratory samples in a high-resource setting with a low tuberculosis prevalence.

    DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE . 99(2): 115235-115235. Number of citations: 5

    [doi:10.1016/j.diagmicrobio.2020.115235]

  • Haro G, Bischofberger Valdes, C, Vicente-Guijarro, J, Diaz-Agero Perez, C, Fabregate-Fuente, M, Moreno-Nunez, P, Aranaz-Andres, J M, Research Group Covid-19 of the Hospital Universitario Ramón y Cajal.

    Decontamination of filtering facepiece respirators using a low-temperature-steam-2%-formaldehyde sterilization process during a pandemic: a safe alternative for re-use.

    JOURNAL OF HOSPITAL INFECTION . 108: 113-119. Number of citations: 3

    [doi:10.1016/j.jhin.2020.10.024]

  • Hernandez-Garcia M, Garcia-Castillo M, Garcia-Fernandez S, Melo-Cristino J, Pinto MF, Goncalves E, Alves V, Vieira AR, Ramalheira E, Sancho L, Diogo J, Ferreira R, Silva T, Chaves C, Bou G, Cercenado E, Delgado-Valverde M, Oliver A, Pitart C, Rodriguez-Lozano J, Tormo N, Romano J, Passaro L, Paixao L, Lopez-Mendoza D, Diaz-Reganon J, Canton R, STEP and SUPERIOR study groups.

    Distinct epidemiology and resistance mechanisms affecting ceftolozane/tazobactam in Pseudomonas aeruginosa isolates recovered from ICU patients in Spain and Portugal depicted by WGS

    The Journal of antimicrobial chemotherapy . 76(2): 370-379. Number of citations: 9

    [doi:10.1093/jac/dkaa430]

  • Baquero, Fernando, Levin, Bruce R..

    Proximate and ultimate causes of the bactericidal action of antibiotics

    NATURE REVIEWS MICROBIOLOGY . 19(2): 123-132. Number of citations: 80

    [doi:10.1038/s41579-020-00443-1]

  • Sainz, Talia, Delgado, Jaime, Mendez-Echevarria, Ana, Santiago, Begona, Lopez-Varela, Elisa, Aguilera-Alonso, David, Saavedra-Lozano, Jesus, Rodriguez-Fernandez, Rosa, Holguin, Africa, Navarro, Marisa L., Angeles Munoz-Fernandez M, Rivero-Calle, Irene, Solana, Maria Jose, Lopez-Herce, Jesus, Calvo, Cristina.

    The clinical relevance of the microbiome when managing paediatric infectious diseases-Narrative review

    ACTA PAEDIATRICA . 110(2): 441-449. Number of citations: 1

    [doi:10.1111/apa.15578]

  • Sanchez-Carrillo, Sergio, Ciordia, Sergio, Rojo, David, Zubeldia-Varela, Elisa, Mendez-Garcia, Celia, Martinez-Martinez, Monica, Barbas, Coral, Ruiz-Ruiz, Susana, Moya, Andres, Garriga, Maria, Salazar, Nuria, Botella-Carretero JI, Vega-Pinero, Belen, de los Reyes-Gavilan, Clara G., del Campo, Rosa, Ferrer, Manuel.

    A body weight loss- and health-promoting gut microbiota is established after bariatric surgery in individuals with severe obesity

    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS . 193: 113747-113747. Number of citations: 11

    [doi:10.1016/j.jpba.2020.113747]

  • Herencias, Cristina, Rodriguez-Beltran, Jeronimo, Leon-Sampedro, Ricardo, Alonso-del Valle, Aida, Palkovicova, Jana, Canton, Rafael, San Millan, Alvaro.

    Collateral sensitivity associated with antibiotic resistance plasmids

    ELIFE . 10: . Number of citations: 13

    [doi:10.7554/eLife.65130]

  • Hernandez-Garcia, Marta, Sanchez-Lopez, Javier, Martinez-Garcia, Laura, Becerra-Aparicio, Federico, Morosini, Maria Isabel, Ruiz-Garbajosa, Patricia, Canton, Rafael.

    Emergence of the New KPC-49 Variant Conferring an ESBL Phenotype with Resistance to Ceftazidime-Avibactam in the ST131-H30R1 Escherichia coli High-Risk Clone

    PATHOGENS . 10(1): . Number of citations: 12

    [doi:10.3390/pathogens10010067]

  • Arevalo-Rodriguez, Ingrid, Seron, Pamela, Buitrago-Garcia, Diana, Ciapponi, Agustin, Muriel, Alfonso, Zambrano-Achig, Paula, del Campo, Rosa, Galan-Montemayor, Juan Carlos, Simancas-Racines, Daniel, Perez-Molina, Jose A., Khan, Khalid Saeed, Zamora, Javier.

    Recommendations for SARS-CoV-2/COVID-19 testing: a scoping review of current guidance

    BMJ open . 11(1): . Number of citations: 14

    [doi:10.1136/bmjopen-2020-043004]

  • Casado JL, Haemmerle J, Vizcarra P, Rodriguez-Dominguez M, Velasco T, Velasco H, Centenera E, Romero-Hernandez B, Fernandez-Escribano M, Vallejo A.

    T-cell response after first dose of BNT162b2 SARS-CoV-2 vaccine among healthcare workers with previous infection or cross-reactive immunity

    CLINICAL & TRANSLATIONAL IMMUNOLOGY . 10(9): . Number of citations: 10

    [doi:10.1002/cti2.1341]

  • Gil-Gil T, Ochoa-Sánchez LE, Baquero F, Martínez JL.

    Antibiotic resistance: Time of synthesis in a post-genomic age

    Computational and Structural Biotechnology Journal . 19: 3110-3124. Number of citations: 14

    [doi:10.1016/j.csbj.2021.05.034]

  • Perez-Nadales, Elena, Alastruey-Izquierdo, Ana, Jose Linares-Sicilia, Maria, Carlos Soto-Debran, Juan, Abdala, Edson, Garcia-Rodriguez, Julio, Montejo, Miguel, Munoz, Patricia, Salavert Lleti, Miguel, Rezusta, Antonio, Perez de Pipaon, Maite Ruiz, Yanez, Lucrecia, Merino, Esperanza, Isolina Campos-Herrero, Maria, Maria Costa-Mateo, Jose, Fortun, Jesus, Garcia-Lozano, Tomas, Garcia-Vidal, Carolina, Fernandez-Ruiz, Mario, Sanchez-Reus, Ferran, Castro-Mendez, Carmen, Guerrero-Lozano, Inmaculada, Soler-Palacin, Pere, Maria Aguado, Jose, Martinez-Martinez, Luis, Torre-Cisneros, Julian, Nucci, Marcio, Spanish Fusariosis Study Grp.

    Invasive Fusariosis in Nonneutropenic Patients, Spain, 2000-2015

    EMERGING INFECTIOUS DISEASES . 27(1): 26-35. Number of citations: 13

    [doi:10.3201/eid2701.190782]

  • Martinez-Sanz, Javier, Jimenez, Daniel, Martinez-Campelo, Laura, Cruz, Raquel, Vizcarra, Pilar, Sanchez-Conde, Matilde, Ron, Raquel, Rodriguez, Mario, Herrera, Sabina, Moreno, Santiago, Lopez-Huertas, Maria Rosa, Serrano-Villar, Sergio.

    Role of ACE2 genetic polymorphisms in susceptibility to SARS-CoV-2 among highly exposed but non infected healthcare workers

    EMERGING MICROBES & INFECTIONS . 10(1): 493-496. Number of citations: 13

    [doi:10.1080/22221751.2021.1902755]