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Neurodegenerative diseases: therapy development

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  • Fernández-Ruiz J, Sagredo O, Pazos MR, García C, Pertwee R, Mechoulam R, Martínez-Orgado J.

    Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY . 75(2): 323-333. Number of citations: 195

    [doi:10.1111/j.1365-2125.2012.04341.x]

  • Casarejos MJ, Perucho J, Gomez A, Muñoz MP, Fernandez-Estevez M, Sagredo O, Fernandez Ruiz J, Guzman M, de Yebenes JG, Mena MA.

    Natural Cannabinoids Improve Dopamine Neurotransmission and Tau and Amyloid Pathology in a Mouse Model of Tauopathy

    JOURNAL OF ALZHEIMERS DISEASE . 35(3): 525-539. Number of citations: 64

    [doi:10.3233/JAD-130050]

  • Granja AG, Carrillo-Salinas F, Pagani A, Gómez-Cañas M, Negri R, Navarrete C, Mecha M, Mestre L, Fiebich BL, Cantarero I, Calzado MA, Bellido ML, Fernandez-Ruiz J, Appendino G, Guaza C, Muñoz E.

    A Cannabigerol Quinone Alleviates Neuroinflammation in a Chronic Model of Multiple Sclerosis

    JOURNAL OF NEUROIMMUNE PHARMACOLOGY . 7(4): 1002-1016. Number of citations: 82

    [doi:10.1007/s11481-012-9399-3]

  • Pazos MR, Cinquina V, Gómez A, Layunta R, Santos M, Fernández-Ruiz J, Martínez-Orgado J.

    Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function

    Neuropharmacology . 63(5): 776-783. Number of citations: 96

    [doi:10.1016/j.neuropharm.2012.05.034]

  • Ruiz C, Casarejos MJ, Rubio I, Gines S, Puigdellivol M, Alberch J, Mena MA, de Yebenes JG.

    The dopaminergic stabilizer, (-)-OSU6162, rescues striatal neurons with normal and expanded polyglutamine chains in huntingtin protein from exposure to free radicals and mitochondrial toxins

    BRAIN RESEARCH . 1459: 100-112. Number of citations: 8

    [doi:10.1016/j.brainres.2012.04.021]

  • de Lago E, Moreno-Martet M, Cabranes A, Ramos JA, Fernández-Ruiz J.

    Cannabinoids ameliorate disease progression in a model of multiple sclerosis in mice, acting preferentially through CB1 receptor-mediated anti-inflammatory effects

    Neuropharmacology . 62(7): 2299-2308. Number of citations: 60

    [doi:10.1016/j.neuropharm.2012.01.030]

  • Valdeolivas S, Satta V, Pertwee RG, Fernández-Ruiz J, Sagredo O.

    Sativex-like Combination of Phytocannabinoids is Neuroprotective in Malonate-Lesioned Rats, an Inflammatory Model of Huntington's Disease: Role of CB1 and CB2 Receptors

    ACS CHEMICAL NEUROSCIENCE . 3(5): 400-406. Number of citations: 58

    [doi:10.1021/cn200114w]

  • Sagredo O, Pazos MR, Valdeolivas S, Fernandez-Ruiz J.

    Cannabinoids: novel medicines for the treatment of Huntington's disease.

    Recent patents on CNS drug discovery . 7(1): 41-48.

  • Cumella J, Hernández-Folgado L, Girón R, Sánchez E, Morales P, Hurst DP, Gómez-Cañas M, Gómez-Ruiz M, Pinto DC, Goya P, Reggio PH, Martin MI, Fernández-Ruiz J, Silva AM, Jagerovic N.

    Chromenopyrazoles: Non-psychoactive and Selective CB1 Cannabinoid Agonists with Peripheral Antinociceptive Properties

    Chemmedchem . 7(3, SI): 452-463. Number of citations: 26

    [doi:10.1002/cmdc.201100568]

  • Perucho J, Casarejos MJ, Gomez A, Solano RM, de Yébenes JG, Mena MA.

    Trehalose protects from aggravation of amyloid pathology induced by isoflurane anesthesia in APP(swe) mutant mice.

    CURR ALZHEIMER RES . 9(3): 334-343.

  • Moreno-Martet M, Mestre L, Loría F, Guaza C, Fernández-Ruiz J, de Lago E.

    Identification of receptors and enzymes for endocannabinoids in NSC-34 cells: Relevance for in vitro studies with cannabinoids in motor neuron diseases

    NEUROSCIENCE LETTERS . 508(2): 67-72. Number of citations: 10

    [doi:10.1016/j.neulet.2011.12.020]

  • Ruiz C, Casarejos MJ, Gomez A, Solano R, de Yebenes JG, Mena MA.

    Protection by glia-conditioned medium in a cell model of Huntington disease.

    PLoS currents . 4: .

    [doi:10.1371/4fbca54a2028b]

  • Solano RM, Casarejos MJ, Gómez A, Perucho J, de Yébenes JG, Mena MA.

    Parkin Null Cortical Neuronal/Glial Cultures are Resistant to Amyloid-beta(1-42) Toxicity: A Role for Autophagy?

    JOURNAL OF ALZHEIMERS DISEASE . 32(1): 57-76. Number of citations: 11

    [doi:10.3233/JAD-2012-120406]

  • Marco I, Valhondo M, Martín-Fontecha M, Vázquez-Villa H, Del Río J, Planas A, Sagredo O, Ramos JA, Torrecillas IR, Pardo L, Frechilla D, Benhamú B, López-Rodríguez ML.

    New Serotonin 5-HT1A Receptor Agonists with Neuroprotective Effect against Ischemic Cell Damage

    JOURNAL OF MEDICINAL CHEMISTRY . 54(23): 7986-7999. Number of citations: 31

    [doi:10.1021/jm2007886]

  • Cardoso-Silva C, Barbería E, Ramos Atance JA, Maroto M, Hernández A, García-Godoy F.

    Microbiological analysis of gingivitis in pediatric patients under orthodontic treatment

    EUROPEAN JOURNAL OF PAEDIATRIC DENTISTRY . 12(4): 210-214. Number of citations: 8

  • Tapia-González S, Giráldez-Pérez RM, Cuartero MI, Casarejos MJ, Mena MÁ, Wang XF, Sánchez-Capelo A.

    Dopamine and alpha- synuclein dysfunction in Smad3 null mice

    MOLECULAR NEURODEGENERATION . 6: 72-72. Number of citations: 37

    [doi:10.1186/1750-1326-6-72]

  • Lafuente H, Alvarez FJ, Pazos MR, Alvarez A, Rey-Santano MC, Mielgo V, Murgia-Esteve X, Hilario E, Martinez-Orgado J.

    Cannabidiol Reduces Brain Damage and Improves Functional Recovery After Acute Hypoxia-Ischemia in Newborn Pigs

    PEDIATRIC RESEARCH . 70(3): 272-277. Number of citations: 65

    [doi:10.1203/PDR.0b013e3182276b11]

  • Sagredo O, Pazos MR, Satta V, Ramos JA, Pertwee RG, Fernández-Ruiz J.

    Neuroprotective Effects of Phytocannabinoid-Based Medicines in Experimental Models of Huntington's Disease

    JOURNAL OF NEUROSCIENCE RESEARCH . 89(9): 1509-1518. Number of citations: 62

    [doi:10.1002/jnr.22682]