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Neurodegenerative diseases: therapy development

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  • Espejo-Porras F, García-Toscano L, Rodríguez-Cueto C, Santos-García I, de Lago E, Fernández-Ruiz J.

    Targeting glial cannabinoid CB 2 receptors to delay the progression of the pathological phenotype in TDP-43 (A315T) transgenic mice, a model of amyotrophic lateral sclerosis.

    BRITISH JOURNAL OF PHARMACOLOGY . 176(10): 1585-1600. Number of citations: 30

    [doi:10.1111/bph.14216]

  • Gómez-Ruiz M, Rodríguez-Cueto C, Luna-Piñel E, Hernández-Gálvez M, Fernández-Ruiz J.

    Endocannabinoid System in Spinocerebellar Ataxia Type-3 and Other Autosomal-Dominant Cerebellar Ataxias: Potential Role in Pathogenesis and Expected Relevance as Neuroprotective Targets.

    FRONTIERS IN MOLECULAR NEUROSCIENCE . 12: 94-94. Number of citations: 8

    [doi:10.3389/fnmol.2019.00094]

  • Sagredo O, Palazuelos J, Gutierrez-Rodriguez A, Satta V, Galve-Roperh I, Martínez-Orgado J.

    Cannabinoid signalling in the immature brain: Encephalopathies and neurodevelopmental disorders.

    BIOCHEMICAL PHARMACOLOGY . 157: 85-96. Number of citations: 9

    [doi:10.1016/j.bcp.2018.08.014]

  • Aymerich MS, Aso E, Abellanas MA, Tolon RM, Ramos JA, Ferrer I, Romero J, Fernández-Ruiz J.

    Cannabinoid pharmacology/therapeutics in chronic degenerative disorders affecting the central nervous system.

    BIOCHEMICAL PHARMACOLOGY . 157: 67-84. Number of citations: 51

    [doi:10.1016/j.bcp.2018.08.016]

  • Rodríguez-Cueto C, Santos-García I, García-Toscano L, Espejo-Porras F, Bellido M, Fernández-Ruiz J, Muñoz E, de Lago E.

    Neuroprotective effects of the cannabigerol quinone derivative VCE-003.2 in SOD1 G93A transgenic mice, an experimental model of amyotrophic lateral sclerosis.

    BIOCHEMICAL PHARMACOLOGY . 157: 217-226. Number of citations: 33

    [doi:10.1016/j.bcp.2018.07.049]

  • Del Rio C, Cantarero I, Palomares B, Gómez-Cañas M, Fernández-Ruiz J, Pavicic C, García-Martín A, Luz Bellido M, Ortega-Castro R, Pérez-Sánchez C, López-Pedrera C, Appendino G, Calzado MA, Muñoz E.

    VCE-004.3, a cannabidiol aminoquinone derivative, prevents bleomycin-induced skin fibrosis and inflammation through PPAR?- and CB 2 receptor-dependent pathways.

    BRITISH JOURNAL OF PHARMACOLOGY . 175(19): 3813-3831. Number of citations: 21

    [doi:10.1111/bph.14450]

  • Espejo-Porras F, Fernández-Ruiz J, de Lago E.

    Analysis of endocannabinoid receptors and enzymes in the post-mortem motor cortex and spinal cord of amyotrophic lateral sclerosis patients.

    AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION . 19(5-6): 377-386. Number of citations: 14

    [doi:10.1080/21678421.2018.1425454]

  • García C, Gómez-Cañas M, Burgaz S, Palomares B, Gómez-Gálvez Y, Palomo-Garo C, Campo S, Ferrer-Hernández J, Pavicic C, Navarrete C, Luz Bellido M, García-Arencibia M, Ruth Pazos M, Muñoz E, Fernández-Ruiz J.

    Benefits of VCE-003.2, a cannabigerol quinone derivative, against inflammation-driven neuronal deterioration in experimental Parkinson's disease: possible involvement of different binding sites at the PPAR? receptor.

    JOURNAL OF NEUROINFLAMMATION . 15(1): 19-19. Number of citations: 32

    [doi:10.1186/s12974-018-1060-5]

  • Murineddu G, Deligia F, Ragusa G, García-Toscano L, Gómez-Cañas M, Asproni B, Satta V, Cichero E, Pazos R, Fossa P, Loriga G, Fernández-Ruiz J, Pinna GA.

    Novel sulfenamides and sulfonamides based on pyridazinone and pyridazine scaffolds as CB 1 receptor ligand antagonists.

    BIOORGANIC & MEDICINAL CHEMISTRY . 26(1): 295-307. Number of citations: 3

    [doi:10.1016/j.bmc.2017.11.051]

  • Fernández-Ruiz J, Gómez-Ruiz M, García C, Hernández M, Ramos JA.

    Modeling Neurodegenerative Disorders for Developing Cannabinoid-Based Neuroprotective Therapies.

    METHOD ENZYMOL . 593: 175-198. Number of citations: 10

    [doi:10.1016/bs.mie.2017.06.021]

  • Lago-Fernandez A, Redondo V, Hernandez-Folgado L, Figuerola-Asencio L, Jagerovic N.

    New Methods for the Synthesis of Cannabidiol Derivatives.

    METHOD ENZYMOL . 593: 237-257. Number of citations: 3

    [doi:10.1016/bs.mie.2017.05.006]

  • Gómez-Cañas M, Morales P, García-Toscano L, Navarrete C, Muñoz E, Jagerovic N, Fernández-Ruiz J, García-Arencibia M, Pazos MR.

    Corrigendum to Biological characterization of PM226, a chromenoisoxazole, as a selective CB 2 receptor agonist with neuroprotective profile [Pharmacol. Res. 110 (August 2016) (2016) 205-215].

    PHARMACOLOGICAL RESEARCH . 120: 302-302.

    [doi:10.1016/j.phrs.2017.04.002]

  • Fernández-Trapero M, Espejo-Porras F, Rodríguez-Cueto C, Coates JR, Pérez-Díaz C, de Lago E, Fernández-Ruiz J.

    Upregulation of CB 2 receptors in reactive astrocytes in canine degenerative myelopathy, a disease model of amyotrophic lateral sclerosis.

    DISEASE MODELS & MECHANISMS . 10(5): 551-558. Number of citations: 33

    [doi:10.1242/dmm.028373]

  • Rodríguez-Cueto C, Hernández-Gálvez M, Hillard CJ, Maciel P, Valdeolivas S, Ramos JA, Gómez-Ruiz M, Fernández-Ruiz J.

    Altered striatal endocannabinoid signaling in a transgenic mouse model of spinocerebellar ataxia type-3.

    Plos One . 12(4): . Number of citations: 4

    [doi:10.1371/journal.pone.0176521]

  • Ceprián M, Jiménez-Sánchez L, Vargas C, Barata L, Hind W, Martínez-Orgado J.

    Cannabidiol reduces brain damage and improves functional recovery in a neonatal rat model of arterial ischemic stroke.

    Neuropharmacology . 116: 151-159. Number of citations: 45

    [doi:10.1016/j.neuropharm.2016.12.017]

  • Valdeolivas S, Sagredo O, Delgado M, Pozo MA, Fernández-Ruiz J.

    Effects of a Sativex-Like Combination of Phytocannabinoids on Disease Progression in R6/2 Mice, an Experimental Model of Huntington's Disease.

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES . 18(4): . Number of citations: 18

    [doi:10.3390/ijms18040684]

  • Ragusa G, Gómez-Cañas M, Morales P, Rodríguez-Cueto C, Pazos MR, Asproni B, Cichero E, Fossa P, Pinna GA, Jagerovic N, Fernández-Ruiz J, Murineddu G.

    New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking.

    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY . 127: 398-412. Number of citations: 9

    [doi:10.1016/j.ejmech.2017.01.002]

  • Rodríguez-Cueto C, Hernández-Gálvez M, Hillard CJ, Maciel P, García-García L, Valdeolivas S, Pozo MA, Ramos JA, Gómez-Ruiz M, Fernández-Ruiz J.

    DYSREGULATION OF THE ENDOCANNABINOID SIGNALING SYSTEM IN THE CEREBELLUM AND BRAINSTEM IN A TRANSGENIC MOUSE MODEL OF SPINOCEREBELLAR ATAXIA TYPE-3

    Neuroscience . 339: 191-209. Number of citations: 15

    [doi:10.1016/j.neuroscience.2016.09.046]