Milestones

1. Humphrey J, Brophy E, Kosoy R, Zeng B, Coccia E, Mattei D, Ravi A, Naito T, Efthymiou AG, Navarro E, De Sanctis C, Flores-Almazan V, Muller BZ, Snijders GJLJ, Allan A, Münch A, Kitata RB, Kleopoulos SP, Argyriou S, Malakates P, Psychogyiou K, Shao Z, Francoeur N, Tsai CF, Gritsenko MA, Monroe ME, Paurus VL, Weitz KK, Shi T, Sebra R, Liu T, de Witte LD, Goate AM, Bennett DA, Haroutunian V, Hoffman GE, Fullard JF, Roussos P, Raj T. Long-read RNA sequencing atlas of human microglia isoforms elucidates diseaseassociated genetic regulation of splicing. Nat Genet. 2025; 57(3):604-615. doi: 10.1038/s41588-025-02099-0.
2. Gómez-Almería M, Gonzalo-Consuegra C, Rodríguez-Cueto C, Cabañas-Cotillas M, Jiménez-Amor A, Machín-Díaz I, Wittwer MB, Dzygiel P, Clemente D, Grether U, Fernández-Ruiz J, de Lago E. Relevance of a peripheral site of action outside the brain-blood barrier for the benefi cial eff ects of CB2 receptor activation in experimental ALS in male mice. Cell Commun Signal. 2025; 23(1):427. doi: 10.1186/s12964-025-02418-2.
3. García-Toscano L, Rodríguez-Cueto C, Furiano A, Hind W, de Lago E, Fernández-Ruiz J. Preclinical evaluation of cannabidiolic acid as a neuroprotective agent in TDP-43 transgenic mice, an experimental model of amyotrophic lateral sclerosis. Biomed Pharmacother. 2025 Aug;189:118288. doi: 10.1016/j.biopha.2025.118288.
4. Alonso C, García-Culebras A, Satta V, Hernández-Fisac I, Sierra Á, Guimaré JA, Lizasoain I, Fernández-Ruiz J, Sagredo O. Investigation in blood-brain barrier integrity and susceptibility to immune cell penetration in a mouse model of Dravet syndrome. Brain Behav Immun Health. 2025 Jan 31;44:100955. doi: 10.1016/j.bbih.2025.100955.
5. Rodríguez-Carreiro S, Gómez-Cañas M, Lubrini F, Gonzalo-Consuegra C, Winkler M, Caprioglio D, Appendino G, García MC, Morales P, Jagerovic N, Fischer JT, Fiebich BL, Goetz MR, Muñoz E, Fernández-Ruiz J. Investigation in the CB1 and CB2 receptor binding profi le and intrinsic activity of (−) and (+)-enantiomers of some naturally occurring phytocannabinoids or synthetic derivatives. European Journal of Medicinal Chemistry Reports 14, 100262 doi: 10.1016/j.ejmcr.2025.100262.