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Neurodegenerative diseases: therapy development

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  • Vázquez C, Tolón RM, Pazos MR, Moreno M, Koester EC, Cravatt BF, Hillard CJ, Romero J.

    Endocannabinoids regulate the activity of astrocytic hemichannels and the microglial response against an injury: In vivo studies

    NEUROBIOLOGY OF DISEASE . 79: 41-50. Number of citations: 30

    [doi:10.1016/j.nbd.2015.04.005]

  • Feliú A, Moreno-Martet M, Mecha M, Carrillo-Salinas FJ, de Lago E, Fernández-Ruiz J, Guaza C.

    A Sativex((R))-like combination of phytocannabinoids as a disease-modifying therapy in a viral model of multiple sclerosis

    BRITISH JOURNAL OF PHARMACOLOGY . 172(14, SI): 3579-3595. Number of citations: 41

    [doi:10.1111/bph.13159]

  • Espejo-Porras F, Piscitelli F, Verde R, Ramos JA, Di Marzo V, de Lago E, Fernández-Ruiz J.

    Changes in the endocannabinoid signaling system in CNS structures of TDP-43 transgenic mice: relevance for a neuroprotective therapy in TDP-43-related disorders

    JOURNAL OF NEUROIMMUNE PHARMACOLOGY . 10(2): 233-244. Number of citations: 30

    [doi:10.1007/s11481-015-9602-4]

  • Bañón S, Rosillo M, Gómez A, Pérez-Elias MJ, Moreno S, Casado JL.

    Effect of a monthly dose of calcidiol in improving vitamin D deficiency and secondary hyperparathyroidism in HIV-infected patients

    Endocrine . 49(2): 528-537. Number of citations: 16

    [doi:10.1007/s12020-014-0489-2]

  • Perucho J, Gonzalo-Gobernado R, Bazan E, Casarejos MJ, Jiménez-Escrig A, Asensio MJ, Herranz AS.

    Optimal excitation and emission wavelengths to analyze amino acids and optimize neurotransmitters quantification using precolumn OPA-derivatization by HPLC

    Amino Acids . 47(5): 963-973. Number of citations: 33

    [doi:10.1007/s00726-015-1925-1]

  • Manso L, Moreno F, Márquez R, Castelo B, Arcediano A, Arroyo M, Ballesteros AI, Calvo I, Echarri MJ, Enrech S, Gómez A, González Del Val R, López-Miranda E, Martín-Angulo M, Martínez-Jañez N, Olier C, Zamora P.

    Use of bevacizumab as a first-line treatment for metastatic breast cancer

    Current Oncology . 22(2): 51-60. Number of citations: 14

    [doi:10.3747/co.22.2210]

  • Morales P, Blasco-Benito S, Andradas C, Gómez-Cañas M, Flores JM, Goya P, Fernández-Ruiz J, Sánchez C, Jagerovic N.

    Selective, Nontoxic CB2 Cannabinoid o-Quinone with in Vivo Activity against Triple-Negative Breast Cancer

    JOURNAL OF MEDICINAL CHEMISTRY . 58(5): 2256-2264. Number of citations: 26

    [doi:10.1021/acs.jmedchem.5b00078]

  • García MC, Cinquina V, Palomo-Garo C, Rábano A, Fernández-Ruiz J.

    Identification of CB2 receptors in human nigral neurons that degenerate in Parkinson's disease

    NEUROSCIENCE LETTERS . 587: 1-4. Number of citations: 61

    [doi:10.1016/j.neulet.2014.12.003]

  • Fernández-Ruiz J, Romero J, Ramos JA.

    Endocannabinoids and Neurodegenerative Disorders: Parkinson's Disease, Huntington's Chorea, Alzheimer's Disease, and Others.

    Handbook of experimental pharmacology . 231: 233-259.

    [doi:10.1007/978-3-319-20825-1_8]

  • Valdeolivas S, Navarrete C, Cantarero I, Bellido ML, Muñoz E, Sagredo O.

    Neuroprotective Properties of Cannabigerol in Huntington's Disease: Studies in R6/2 Mice and 3-Nitropropionate-lesioned Mice

    Neurotherapeutics . 12(1): 185-199. Number of citations: 67

    [doi:10.1007/s13311-014-0304-z]

  • Ooms M, Rietjens R, Rangarajan JR, Vunckx K, Valdeolivas S, Maes F, Himmelreich U, Fernandez-Ruiz J, Bormans G, Van Laere K, Casteels C.

    Early decrease of type 1 cannabinoid receptor binding and phosphodiesterase 10A activity in vivo in R6/2 Huntington mice

    NEUROBIOLOGY OF AGING . 35(12): 2858-2869. Number of citations: 24

    [doi:10.1016/j.neurobiolaging.2014.06.010]

  • Fernandes VS, Ribeiro AS, Martínez P, López-Oliva ME, Barahona MV, Orensanz LM, Martínez-Sáenz A, Recio P, Benedito S, Bustamante S, García-Sacristán A, Prieto D, Hernández M.

    Hydrogen Sulfide Plays a Key Role in the Inhibitory Neurotransmission to the Pig Intravesical Ureter

    Plos One . 9(11): . Number of citations: 19

    [doi:10.1371/journal.pone.0113580]

  • Calatrava-Ferreras L, Gonzalo-Gobernado R, Reimers D, Herranz AS, Jiménez-Escrig A, Díaz-Gil JJ, Casarejos MJ, Montero-Vega MT, Bazán E.

    Neuroprotective Role of Liver Growth Factor ``LGF'' in an Experimental Model of Cerebellar Ataxia

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES . 15(10): 19056-19073. Number of citations: 4

    [doi:10.3390/ijms151019056]

  • Casarejos MJ, Perucho J, López-Sendón JL, García de Yébenes J, Bettencourt C, Gómez A, Ruiz C, Heutink P, Rizzu P, Mena MA.

    Trehalose Improves Human Fibroblast Deficits in a New CHIP-Mutation Related Ataxia

    Plos One . 9(9): . Number of citations: 21

    [doi:10.1371/journal.pone.0106931]

  • Moreno-Martet M, Espejo-Porras F, Fernández-Ruiz J, de Lago E.

    Changes in Endocannabinoid Receptors and Enzymes in the Spinal Cord of SOD1(G93A) Transgenic Mice and Evaluation of a Sativex (R)-like Combination of Phytocannabinoids: Interest for Future Therapies in Amyotrophic Lateral Sclerosis

    CNS NEUROSCIENCE & THERAPEUTICS . 20(9): 809-815. Number of citations: 37

    [doi:10.1111/cns.12262]

  • Moreno E, Andradas C, Medrano M, Caffarel MM, Pérez-Gómez E, Blasco-Benito S, Gómez-Cañas M, Pazos MR, Irving AJ, Lluís C, Canela EI, Fernández-Ruiz J, Guzmán M, McCormick PJ, Sánchez C.

    Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling

    JOURNAL OF BIOLOGICAL CHEMISTRY . 289(32): 21960-21972. Number of citations: 71

    [doi:10.1074/jbc.M114.561761]

  • Chiarlone A, Bellocchio L, Blázquez C, Resel E, Soria-Gómez E, Cannich A, Ferrero JJ, Sagredo O, Benito C, Romero J, Sánchez-Prieto J, Lutz B, Fernández-Ruiz J, Galve-Roperh I, Guzmán M.

    A restricted population of CB1 cannabinoid receptors with neuroprotective activity

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA . 111(22): 8257-8262. Number of citations: 109

    [doi:10.1073/pnas.1400988111]

  • Ribeiro AS, Fernandes VS, Martínez MP, Martínez-Sáenz A, Pazos MR, Orensanz LM, Recio P, Bustamante S, Carballido J, García-Sacristán A, Prieto D, Hernández M.

    Neuronal and non-neuronal bradykinin receptors are involved in the contraction and/or relaxation to the pig bladder neck smooth muscle

    NEUROUROLOGY AND URODYNAMICS . 33(5): 558-565. Number of citations: 3

    [doi:10.1002/nau.22434]