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Neurodegenerative diseases: therapy development

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  • Bañón S, Rosillo M, Gómez A, Pérez-Elias MJ, Moreno S, Casado JL.

    Effect of a monthly dose of calcidiol in improving vitamin D deficiency and secondary hyperparathyroidism in HIV-infected patients

    Endocrine . 49(2): 528-537. Number of citations: 16

    [doi:10.1007/s12020-014-0489-2]

  • Perucho J, Gonzalo-Gobernado R, Bazan E, Casarejos MJ, Jiménez-Escrig A, Asensio MJ, Herranz AS.

    Optimal excitation and emission wavelengths to analyze amino acids and optimize neurotransmitters quantification using precolumn OPA-derivatization by HPLC

    Amino Acids . 47(5): 963-973. Number of citations: 33

    [doi:10.1007/s00726-015-1925-1]

  • Manso L, Moreno F, Márquez R, Castelo B, Arcediano A, Arroyo M, Ballesteros AI, Calvo I, Echarri MJ, Enrech S, Gómez A, González Del Val R, López-Miranda E, Martín-Angulo M, Martínez-Jañez N, Olier C, Zamora P.

    Use of bevacizumab as a first-line treatment for metastatic breast cancer

    Current Oncology . 22(2): 51-60. Number of citations: 14

    [doi:10.3747/co.22.2210]

  • Morales P, Blasco-Benito S, Andradas C, Gómez-Cañas M, Flores JM, Goya P, Fernández-Ruiz J, Sánchez C, Jagerovic N.

    Selective, Nontoxic CB2 Cannabinoid o-Quinone with in Vivo Activity against Triple-Negative Breast Cancer

    JOURNAL OF MEDICINAL CHEMISTRY . 58(5): 2256-2264. Number of citations: 26

    [doi:10.1021/acs.jmedchem.5b00078]

  • García MC, Cinquina V, Palomo-Garo C, Rábano A, Fernández-Ruiz J.

    Identification of CB2 receptors in human nigral neurons that degenerate in Parkinson's disease

    NEUROSCIENCE LETTERS . 587: 1-4. Number of citations: 61

    [doi:10.1016/j.neulet.2014.12.003]

  • Fernández-Ruiz J, Romero J, Ramos JA.

    Endocannabinoids and Neurodegenerative Disorders: Parkinson's Disease, Huntington's Chorea, Alzheimer's Disease, and Others.

    Handbook of experimental pharmacology . 231: 233-259.

    [doi:10.1007/978-3-319-20825-1_8]

  • Valdeolivas S, Navarrete C, Cantarero I, Bellido ML, Muñoz E, Sagredo O.

    Neuroprotective Properties of Cannabigerol in Huntington's Disease: Studies in R6/2 Mice and 3-Nitropropionate-lesioned Mice

    Neurotherapeutics . 12(1): 185-199. Number of citations: 67

    [doi:10.1007/s13311-014-0304-z]

  • Ooms M, Rietjens R, Rangarajan JR, Vunckx K, Valdeolivas S, Maes F, Himmelreich U, Fernandez-Ruiz J, Bormans G, Van Laere K, Casteels C.

    Early decrease of type 1 cannabinoid receptor binding and phosphodiesterase 10A activity in vivo in R6/2 Huntington mice

    NEUROBIOLOGY OF AGING . 35(12): 2858-2869. Number of citations: 24

    [doi:10.1016/j.neurobiolaging.2014.06.010]

  • Fernandes VS, Ribeiro AS, Martínez P, López-Oliva ME, Barahona MV, Orensanz LM, Martínez-Sáenz A, Recio P, Benedito S, Bustamante S, García-Sacristán A, Prieto D, Hernández M.

    Hydrogen Sulfide Plays a Key Role in the Inhibitory Neurotransmission to the Pig Intravesical Ureter

    Plos One . 9(11): . Number of citations: 19

    [doi:10.1371/journal.pone.0113580]

  • Calatrava-Ferreras L, Gonzalo-Gobernado R, Reimers D, Herranz AS, Jiménez-Escrig A, Díaz-Gil JJ, Casarejos MJ, Montero-Vega MT, Bazán E.

    Neuroprotective Role of Liver Growth Factor ``LGF'' in an Experimental Model of Cerebellar Ataxia

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES . 15(10): 19056-19073. Number of citations: 4

    [doi:10.3390/ijms151019056]

  • Casarejos MJ, Perucho J, López-Sendón JL, García de Yébenes J, Bettencourt C, Gómez A, Ruiz C, Heutink P, Rizzu P, Mena MA.

    Trehalose Improves Human Fibroblast Deficits in a New CHIP-Mutation Related Ataxia

    Plos One . 9(9): . Number of citations: 21

    [doi:10.1371/journal.pone.0106931]

  • Moreno-Martet M, Espejo-Porras F, Fernández-Ruiz J, de Lago E.

    Changes in Endocannabinoid Receptors and Enzymes in the Spinal Cord of SOD1(G93A) Transgenic Mice and Evaluation of a Sativex (R)-like Combination of Phytocannabinoids: Interest for Future Therapies in Amyotrophic Lateral Sclerosis

    CNS NEUROSCIENCE & THERAPEUTICS . 20(9): 809-815. Number of citations: 37

    [doi:10.1111/cns.12262]

  • Moreno E, Andradas C, Medrano M, Caffarel MM, Pérez-Gómez E, Blasco-Benito S, Gómez-Cañas M, Pazos MR, Irving AJ, Lluís C, Canela EI, Fernández-Ruiz J, Guzmán M, McCormick PJ, Sánchez C.

    Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling

    JOURNAL OF BIOLOGICAL CHEMISTRY . 289(32): 21960-21972. Number of citations: 71

    [doi:10.1074/jbc.M114.561761]

  • Chiarlone A, Bellocchio L, Blázquez C, Resel E, Soria-Gómez E, Cannich A, Ferrero JJ, Sagredo O, Benito C, Romero J, Sánchez-Prieto J, Lutz B, Fernández-Ruiz J, Galve-Roperh I, Guzmán M.

    A restricted population of CB1 cannabinoid receptors with neuroprotective activity

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA . 111(22): 8257-8262. Number of citations: 109

    [doi:10.1073/pnas.1400988111]

  • Ribeiro AS, Fernandes VS, Martínez MP, Martínez-Sáenz A, Pazos MR, Orensanz LM, Recio P, Bustamante S, Carballido J, García-Sacristán A, Prieto D, Hernández M.

    Neuronal and non-neuronal bradykinin receptors are involved in the contraction and/or relaxation to the pig bladder neck smooth muscle

    NEUROUROLOGY AND URODYNAMICS . 33(5): 558-565. Number of citations: 3

    [doi:10.1002/nau.22434]

  • Devinsky O, Cilio MR, Cross H, Fernandez-Ruiz J, French J, Hill C, Katz R, Di Marzo V, Jutras-Aswad D, Notcutt WG, Martinez-Orgado J, Robson PJ, Rohrback BG, Thiele E, Whalley B, Friedman D.

    Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders

    Epilepsia . 55(6): 791-802. Number of citations: 502

    [doi:10.1111/epi.12631]

  • Rodríguez-Cueto C, Benito C, Fernández-Ruiz J, Romero J, Hernández-Gálvez M, Gómez-Ruiz M.

    Changes in CB1 and CB2 receptors in the post- mortem cerebellum of humans affected by spinocerebellar ataxias

    BRITISH JOURNAL OF PHARMACOLOGY . 171(6, SI): 1472-1489. Number of citations: 39

    [doi:10.1111/bph.12283]

  • Fernandez-Estevez MA, Casarejos MJ, López Sendon J, Garcia Caldentey J, Ruiz C, Gomez A, Perucho J, de Yebenes JG, Mena MA.

    Trehalose Reverses Cell Malfunction in Fibroblasts from Normal and Huntington's Disease Patients Caused by Proteosome Inhibition

    Plos One . 9(2): . Number of citations: 43

    [doi:10.1371/journal.pone.0090202]