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Neurodegenerative diseases: therapy development

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  • Gómez-Cañas M, Rodríguez-Cueto C, Satta V, Hernández-Fisac I, Navarro E, Fernández-Ruiz J.

    Endocannabinoid-Binding Receptors as Drug Targets.

    Methods in molecular biology (Clifton, N.J.) . 2576: 67-94.

    [doi:10.1007/978-1-0716-2728-0_6]

  • Figuerola-Asencio, Laura, Morales, Paula, Zhao, Pingwei, Hurst, Dow P., Sayed, Sommayah S., Colon, Katsuya L., Gomez-Canas, Maria, Fernandez-Ruiz, Javier, Croatt, Mitchell P., Reggio, Patricia H., Abood, Mary E., Jagerovic, Nadine.

    Thienopyrimidine Derivatives as GPR55 Receptor Antagonists: Insight into Structure-Activity Relationship

    ACS MEDICINAL CHEMISTRY LETTERS . 14(1): 18-25.

    [doi:10.1021/acsmedchemlett.2c00325]

  • Maestro I, de la Ballina LR, Porras G, Corrochano S, De Lago E, Simonsen A, Boya P, Martinez A.

    Discovery of Mitophagy Inhibitors with Therapeutic Potential in Different Familial Amyotrophic Lateral Sclerosis Mutations.

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES . 23(20): . Number of citations: 1

    [doi:10.3390/ijms232012676]

  • Lastres-Becker I, de Lago E, Martínez A, Fernández-Ruiz J.

    New Statement about NRF2 in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.

    Biomolecules . 12(9): .

    [doi:10.3390/biom12091200]

  • Alonso C, Satta V, Díez-Gutiérrez P, Fernández-Ruiz J, Sagredo O.

    Preclinical investigation of ß-caryophyllene as a therapeutic agent in an experimental murine model of Dravet syndrome

    Neuropharmacology . 205: 108914-108914. Number of citations: 4

    [doi:10.1016/j.neuropharm.2021.108914]

  • Burgaz S, García C, Gonzalo-Consuegra C, Gómez-Almería M, Ruiz-Pino F, Unciti JD, Gómez-Cañas M, Alcalde J, Morales P, Jagerovic N, Rodríguez-Cueto C, de Lago E, Muñoz E, Fernández-Ruiz J.

    Preclinical Investigation in Neuroprotective Effects of the GPR55 Ligand VCE-006.1 in Experimental Models of Parkinson's Disease and Amyotrophic Lateral Sclerosis

    Molecules . 26(24): . Number of citations: 6

    [doi:10.3390/molecules26247643]

  • Gómez-Almería M, Burgaz S, Costas-Insua C, Rodríguez-Cueto C, Santos-García I, Rodríguez-Crespo I, García C, Guzmán M, de Lago E, Fernández-Ruiz J.

    BiP Heterozigosity Aggravates Pathological Deterioration in Experimental Amyotrophic Lateral Sclerosis

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES . 22(22): . Number of citations: 2

    [doi:10.3390/ijms222212533]

  • Rodriguez-Cueto, Carmen, Gomez-Almeria, Marta, Garcia Toscano, Laura, Romero, Julian, Hillard, Cecilia J., de Lago, Eva, Fernandez-Ruiz, Javier.

    Inactivation of the CB2 receptor accelerated the neuropathological deterioration in TDP-43 transgenic mice, a model of amyotrophic lateral sclerosis

    BRAIN PATHOLOGY . 31(6): . Number of citations: 11

    [doi:10.1111/bpa.12972]

  • Gonzalez-Mariscal, Isabel, Carmona-Hidalgo, Beatriz, Winkler, Matthias, Unciti-Broceta, Juan D, Escamilla, Alejandro, Gomez-Canas, Maria, Fernandez-Ruiz, Javier, Fiebich, Bernd L, Romero-Zerbo, Silvana-Yanina, Bermudez-Silva, Francisco J, Collado, Juan A, Muñoz E.

    (+)-trans-Cannabidiol-2-hydroxy pentyl is a dual CB1R antagonist/CB2R agonist that prevents diabetic nephropathy in mice

    PHARMACOLOGICAL RESEARCH . 169: 105492-105492. Number of citations: 6

    [doi:10.1016/j.phrs.2021.105492]

  • Burgaz S, García C, Gómez-Cañas M, Rolland A, Muñoz E, Fernández-Ruiz J.

    Neuroprotection with the Cannabidiol Quinone Derivative VCE-004.8 (EHP-101) against 6-Hydroxydopamine in Cell and Murine Models of Parkinson's Disease

    Molecules . 26(11): . Number of citations: 6

    [doi:10.3390/molecules26113245]

  • Galan-Ganga, M., Rodriguez-Cueto, C., Merchan-Rubira, J., Hernandez, F., avila, J., Posada-Ayala, M., Lanciego, J. L., Luengo, E., Lopez, M. G., Rabano, A., Fernandez-Ruiz, J., Lastres-Becker, I..

    Cannabinoid receptor CB2 ablation protects against TAU induced neurodegeneration

    Acta neuropathologica communications . 9(1): 90-90. Number of citations: 14

    [doi:10.1186/s40478-021-01196-5]

  • Sanchez Montero, Jose Maria, Agis-Torres, Angel, Solano, David, Söllhuber M, Fernandez, Maria, Villaro, Wilma, Gomez-Canas, Maria, Garcia-Arencibia, Moises, Fernandez-Ruiz, Javier, Egea, Javier, Martín MI, Giron, Rocio.

    Analogues of cannabinoids as multitarget drugs in the treatment of Alzheimer's disease

    EUROPEAN JOURNAL OF PHARMACOLOGY . 895: 173875-173875. Number of citations: 7

    [doi:10.1016/j.ejphar.2021.173875]

  • Rodríguez-Cueto C, García-Toscano L, Santos-García I, Gómez-Almería M, Gonzalo-Consuegra C, Espejo-Porras F, Fernández-Ruiz J, de Lago E.

    Targeting the CB2 receptor and other endocannabinoid elements to delay disease progression in amyotrophic lateral sclerosis

    BRITISH JOURNAL OF PHARMACOLOGY . 178(6): 1373-1387. Number of citations: 11

    [doi:10.1111/bph.15386]

  • Rojas, Pilar, Ramirez, Ana I., Cadena, Manuel, Fernandez-Albarral, Jose A., Salobrar-Garcia, Elena, Lopez-Cuenca, Ines, Santos-Garcia, Irene, de Lago, Eva, Urcelay-Segura, Jose L., Ramirez, Jose M., de Hoz, Rosa, Salazar, Juan J..

    Retinal Ganglion Cell Loss and Microglial Activation in a SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES . 22(4): . Number of citations: 6

    [doi:10.3390/ijms22041663]

  • Satta, Valentina, Alonso, Cristina, Diez, Paula, Martin-Suarez, Soraya, Rubio, Marta, Encinas, Juan M., Fernandez-Ruiz, Javier, Sagredo, Onintza.

    Neuropathological Characterization of a Dravet Syndrome Knock-In Mouse Model Useful for Investigating Cannabinoid Treatments

    FRONTIERS IN MOLECULAR NEUROSCIENCE . 13: 602801-602801. Number of citations: 12

    [doi:10.3389/fnmol.2020.602801]

  • Burgaz, Sonia, Garcia, Concepcion, Gomez-Canas, Maria, Navarrete, Carmen, Garcia-Martin, Adela, Rolland, Alain, del Rio, Carmen, Casarejos, Maria J., Muñoz E, Gonzalo-Consuegra, Claudia, Muñoz E, Fernandez-Ruiz, Javier.

    Neuroprotection with the cannabigerol quinone derivative VCE-003.2 and its analogs CBGA-Q and CBGA-Q-Salt in Parkinson's disease using 6-hydroxydopamine-lesioned mice

    MOLECULAR AND CELLULAR NEUROSCIENCE . 110: 103583-103583. Number of citations: 11

    [doi:10.1016/j.mcn.2020.103583]

  • Morales, Paula, Navarro, Gemma, Gomez-Autet, Marc, Redondo, Laura, Fernandez-Ruiz, Javier, Perez-Benito, Laura, Cordomi, Arnau, Pardo, Leonardo, Franco, Rafael, Jagerovic, Nadine.

    Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor**

    CHEMISTRY-A EUROPEAN JOURNAL . 26(68): 15839-15842. Number of citations: 15

    [doi:10.1002/chem.202003389]

  • Palomares, Belen, Garrido-Rodriguez, Martin, Gonzalo-Consuegra, Claudia, Gomez-Canas, Maria, Saen-oon, Suwipa, Soliva, Robert, Collado, Juan A., Fernandez-Ruiz, Javier, Morello, Gaetano, Calzado, Marco A., Appendino, Giovanni, Muñoz E.

    Delta(9)-Tetrahydrocannabinolic acid alleviates collagen-induced arthritis: Role of PPAR gamma and CB(1)receptors

    BRITISH JOURNAL OF PHARMACOLOGY . 177(17): 4034-4054. Number of citations: 9

    [doi:10.1111/bph.15155]