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Neurodegenerative diseases: therapy development

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  • Burgaz S, Navarro E, Rodríguez-Carreiro S, Navarrete C, Garrido-Rodríguez M, Lastres-Becker I, Chocarro J, Lanciego JL, Muñoz E, Fernández-Ruiz J.

    Investigation in the cannabigerol derivative VCE-003.2 as a disease-modifying agent in a mouse model of experimental synucleinopathy.

    BEHAVIORAL AND BRAIN FUNCTIONS . 20(1): 28-28.

    [doi:10.1186/s12993-024-00256-9]

  • Silva-Llanes I, Martín-Baquero R, Berrojo-Armisen A, Rodríguez-Cueto C, Fernández-Ruiz J, De Lago E, Lastres-Becker I.

    Beneficial Effect of Dimethyl Fumarate Drug Repositioning in a Mouse Model of TDP-43-Dependent Frontotemporal Dementia.

    ANTIOXIDANTS . 13(9): .

    [doi:10.3390/antiox13091072]

  • Aebi J, Atz K, Ametamey SM, Benz J, Blaising J, Butini S, Campiani G, Carreira EM, Collin L, de Lago E, Gazzi T, Gertsch J, Gobbi L, Guba W, Fernández-Ruiz J, Fingerle J, Haider A, He Y, Heitman LH, Honer M, Hunziker D, Kuhn B, Maccarrone M, Märki HP, Martin RE, Mohr P, Mu L, Nazaré M, Nippa DF, Oddi S, O'Hara F, Pacher P, Romero J, Röver S, Rufer AC, Schibli R, Schneider G, Stepan AF, Sykes DA, Ullmer C, Van der Stelt M, Veprintsev DB, Wittwer MB, Grether U.

    Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche's Endocannabinoid System Projects.

    Chimia . 78(7-8): 499-512.

    [doi:10.2533/chimia.2024.499]

  • Navarro E, Esteras N.

    A new mutation in the Parkinson's-related FBXO7 gene impairs mitochondrial and proteasomal function.

    FEBS JOURNAL . 291(12): 2562-2564.

    [doi:10.1111/febs.17155]

  • Gonzalo-Consuegra C, Santos-García I, García-Toscano L, Martín-Baquero R, Rodríguez-Cueto C, Wittwer MB, Dzygiel P, Grether U, de Lago E, Fernández-Ruiz J.

    Involvement of CB(1) and CB(2) receptors in neuroprotective effects of cannabinoids in experimental TDP-43 related frontotemporal dementia using male mice.

    BIOMEDICINE & PHARMACOTHERAPY . 174: 116473-116473.

    [doi:10.1016/j.biopha.2024.116473]

  • Alonso C, Satta V, Hernández-Fisac I, Fernández-Ruiz J, Sagredo O.

    Disease-modifying effects of cannabidiol, ß-caryophyllene and their combination in Syn1-Cre/Scn1aWT/A1783V mice, a preclinical model of Dravet syndrome

    Neuropharmacology . 237: 109602-109602.

    [doi:10.1016/j.neuropharm.2023.109602]

  • Rodríguez-Carreiro S, Navarro E, Muñoz E, Fernández-Ruiz J.

    The Cannabigerol Derivative VCE-003.2 Exerts Therapeutic Effects in 6-Hydroxydopamine-Lesioned Mice: Comparison with The Classic Dopaminergic Replacement Therapy.

    Brain Sciences . 13(9): .

    [doi:10.3390/brainsci13091272]

  • Santos-García I, Rodríguez-Cueto C, Villegas P, Piscitelli F, Lauritano A, Shen CJ, Di Marzo V, Fernández-Ruiz J, de Lago E.

    Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice.

    JOURNAL OF NEUROINFLAMMATION . 20(1): 108-108.

    [doi:10.1186/s12974-023-02792-z]

  • Salazar JJ, Satriano A, Matamoros JA, Fernández-Albarral JA, Salobrar-García E, López-Cuenca I, de Hoz R, Sánchez-Puebla L, Ramírez JM, Alonso C, Satta V, Hernández-Fisac I, Sagredo O, Ramírez AI.

    Retinal Tissue Shows Glial Changes in a Dravet Syndrome Knock-in Mouse Model.

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES . 24(3): .

    [doi:10.3390/ijms24032727]

  • Gómez-Cañas M, Rodríguez-Cueto C, Satta V, Hernández-Fisac I, Navarro E, Fernández-Ruiz J.

    Endocannabinoid-Binding Receptors as Drug Targets.

    Methods in molecular biology (Clifton, N.J.) . 2576: 67-94.

    [doi:10.1007/978-1-0716-2728-0_6]

  • Figuerola-Asencio, Laura, Morales, Paula, Zhao, Pingwei, Hurst, Dow P., Sayed, Sommayah S., Colon, Katsuya L., Gomez-Canas, Maria, Fernandez-Ruiz, Javier, Croatt, Mitchell P., Reggio, Patricia H., Abood, Mary E., Jagerovic, Nadine.

    Thienopyrimidine Derivatives as GPR55 Receptor Antagonists: Insight into Structure-Activity Relationship

    ACS MEDICINAL CHEMISTRY LETTERS . 14(1): 18-25.

    [doi:10.1021/acsmedchemlett.2c00325]

  • Maestro I, de la Ballina LR, Porras G, Corrochano S, De Lago E, Simonsen A, Boya P, Martinez A.

    Discovery of Mitophagy Inhibitors with Therapeutic Potential in Different Familial Amyotrophic Lateral Sclerosis Mutations.

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES . 23(20): . Number of citations: 1

    [doi:10.3390/ijms232012676]

  • Lastres-Becker I, de Lago E, Martínez A, Fernández-Ruiz J.

    New Statement about NRF2 in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.

    Biomolecules . 12(9): .

    [doi:10.3390/biom12091200]

  • Alonso C, Satta V, Díez-Gutiérrez P, Fernández-Ruiz J, Sagredo O.

    Preclinical investigation of ß-caryophyllene as a therapeutic agent in an experimental murine model of Dravet syndrome

    Neuropharmacology . 205: 108914-108914. Number of citations: 4

    [doi:10.1016/j.neuropharm.2021.108914]

  • Burgaz S, García C, Gonzalo-Consuegra C, Gómez-Almería M, Ruiz-Pino F, Unciti JD, Gómez-Cañas M, Alcalde J, Morales P, Jagerovic N, Rodríguez-Cueto C, de Lago E, Muñoz E, Fernández-Ruiz J.

    Preclinical Investigation in Neuroprotective Effects of the GPR55 Ligand VCE-006.1 in Experimental Models of Parkinson's Disease and Amyotrophic Lateral Sclerosis

    Molecules . 26(24): . Number of citations: 6

    [doi:10.3390/molecules26247643]

  • Gómez-Almería M, Burgaz S, Costas-Insua C, Rodríguez-Cueto C, Santos-García I, Rodríguez-Crespo I, García C, Guzmán M, de Lago E, Fernández-Ruiz J.

    BiP Heterozigosity Aggravates Pathological Deterioration in Experimental Amyotrophic Lateral Sclerosis

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES . 22(22): . Number of citations: 2

    [doi:10.3390/ijms222212533]

  • Rodriguez-Cueto, Carmen, Gomez-Almeria, Marta, Garcia Toscano, Laura, Romero, Julian, Hillard, Cecilia J., de Lago, Eva, Fernandez-Ruiz, Javier.

    Inactivation of the CB2 receptor accelerated the neuropathological deterioration in TDP-43 transgenic mice, a model of amyotrophic lateral sclerosis

    BRAIN PATHOLOGY . 31(6): . Number of citations: 11

    [doi:10.1111/bpa.12972]

  • Gonzalez-Mariscal, Isabel, Carmona-Hidalgo, Beatriz, Winkler, Matthias, Unciti-Broceta, Juan D, Escamilla, Alejandro, Gomez-Canas, Maria, Fernandez-Ruiz, Javier, Fiebich, Bernd L, Romero-Zerbo, Silvana-Yanina, Bermudez-Silva, Francisco J, Collado, Juan A, Muñoz E.

    (+)-trans-Cannabidiol-2-hydroxy pentyl is a dual CB1R antagonist/CB2R agonist that prevents diabetic nephropathy in mice

    PHARMACOLOGICAL RESEARCH . 169: 105492-105492. Number of citations: 6

    [doi:10.1016/j.phrs.2021.105492]