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Neurodegenerative diseases: therapy development

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  • González-Naranjo P, Pérez-Macias N, Campillo NE, Pérez C, Arán VJ, Girón R, Sánchez-Robles E, Martín MI, Gómez-Cañas M, García-Arencibia M, Fernández-Ruiz J, Páez JA.

    Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease

    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY . 73: 56-72. Number of citations: 36

    [doi:10.1016/j.ejmech.2013.11.026]

  • Gonzalo-Gobernado R, Calatrava-Ferreras L, Perucho J, Reimers D, Casarejos MJ, Herranz AS, Jimenez-Escrig A, Diaz-Gil JJ, Bazan E.

    Liver growth factor as a tissue regenerating factor in neurodegenerative diseases.

    Recent patents on CNS drug discovery . 9(3): 173-180.

  • Rodríguez-Cueto C, Benito C, Romero J, Hernández-Gálvez M, Gómez-Ruiz M, Fernández-Ruiz J.

    Endocannabinoid-Hydrolysing Enzymes in the Post-Mortem Cerebellum of Humans Affected by Hereditary Autosomal Dominant Ataxias

    Pathobiology . 81(3): 149-159. Number of citations: 9

    [doi:10.1159/000358127]

  • Fernández-Fernández C, Callado LF, Girón R, Sánchez E, Erdozain AM, López-Moreno JA, Morales P, Rodríguez de Fonseca F, Fernández-Ruiz J, Goya P, Meana JJ, Martín MI, Jagerovic N.

    Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results

    DRUG DESIGN DEVELOPMENT AND THERAPY . 8: 263-277. Number of citations: 14

    [doi:10.2147/DDDT.S55045]

  • Morales P, Vara D, Goméz-Cañas M, Zúñiga MC, Olea-Azar C, Goya P, Fernández-Ruiz J, Díaz-Laviada I, Jagerovic N.

    Synthetic cannabinoid quinones: Preparation, in vitro antiproliferative effects and in vivo prostate antitumor activity

    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY . 70: 111-119. Number of citations: 28

    [doi:10.1016/j.ejmech.2013.09.043]

  • Espejo-Porras F, Fernández-Ruiz J, Pertwee RG, Mechoulam R, García C.

    Motor effects of the non-psychotropic phytocannabinoid cannabidiol that are mediated by 5-HT1A receptors

    Neuropharmacology . 75(SI): 155-163. Number of citations: 43

    [doi:10.1016/j.neuropharm.2013.07.024]

  • Pryce G, Cabranes A, Fernández-Ruiz J, Bisogno T, Di Marzo V, Long JZ, Cravatt BF, Giovannoni G, Baker D.

    Control of experimental spasticity by targeting the degradation of endocannabinoids using selective fatty acid amide hydrolase inhibitors

    MULTIPLE SCLEROSIS JOURNAL . 19(14): 1896-1904. Number of citations: 27

    [doi:10.1177/1352458513485982]

  • Valhondo M, Marco I, Martín-Fontecha M, Vázquez-Villa H, Ramos JA, Berkels R, Lauterbach T, Benhamú B, López-Rodríguez ML.

    New Serotonin 5-HT1A Receptor Agonists Endowed with Antinociceptive Activity in Vivo

    JOURNAL OF MEDICINAL CHEMISTRY . 56(20): 7851-7861. Number of citations: 22

    [doi:10.1021/jm400766k]

  • Valdeolivas S, Pazos MR, Bisogno T, Piscitelli F, Iannotti FA, Allarà M, Sagredo O, Di Marzo V, Fernández-Ruiz J.

    The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG

    CELL DEATH & DISEASE . 4: . Number of citations: 64

    [doi:10.1038/cddis.2013.387]

  • Perucho J, Casarejos MJ, Gómez A, Ruíz C, Fernández-Estevez MÁ, Muñoz MP, de Yébenes JG, Mena MÁ.

    Striatal Infusion of Glial Conditioned Medium Diminishes Huntingtin Pathology in R6/1 Mice

    Plos One . 8(9): . Number of citations: 9

    [doi:10.1371/journal.pone.0073120]

  • Pazos MR, Mohammed N, Lafuente H, Santos M, Martínez-Pinilla E, Moreno E, Valdizan E, Romero J, Pazos A, Franco R, Hillard CJ, Alvarez FJ, Martínez-Orgado J.

    Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: Role of 5HT(1A) and CB2 receptors

    Neuropharmacology . 71: 282-291. Number of citations: 132

    [doi:10.1016/j.neuropharm.2013.03.027]

  • Gómez del Rio MA, Sánchez-Reus MI, Iglesias I, Pozo MA, García-Arencibia M, Fernández-Ruiz J, García-García L, Delgado M, Benedí J.

    Neuroprotective Properties of Standardized Extracts of Hypericum perforatum on Rotenone Model of Parkinson's Disease.

    CNS NEUROL DISORD-DR . 12(5): 665-679.

  • Alvarado M, Decara J, Luque MJ, Hernandez-Folgado L, Gómez-Cañas M, Gómez-Ruiz M, Fernández-Ruiz J, Elguero J, Jagerovic N, Serrano A, Goya P, de Fonseca FR.

    Novel antiobesity agents: Synthesis and pharmacological evaluation of analogues of Rimonabant and of LH21

    BIOORGANIC & MEDICINAL CHEMISTRY . 21(7): 1708-1716. Number of citations: 16

    [doi:10.1016/j.bmc.2013.01.055]

  • Fernández-Fernández C, Decara J, Bermúdez-Silva FJ, Sánchez E, Morales P, Gómez-Cañas M, Gómez-Ruíz M, Callado LF, Goya P, Rodríguez de Fonseca F, Martín MI, Fernández-Ruíz J, Meana JJ, Jagerovic N.

    Description of a Bivalent Cannabinoid Ligand with Hypophagic Properties

    ARCHIV DER PHARMAZIE . 346(3): 171-179. Number of citations: 11

    [doi:10.1002/ardp.201200392]

  • Llorente-Folch I, Sahún I, Contreras L, Casarejos MJ, Grau JM, Saheki T, Mena MA, Satrústegui J, Dierssen M, Pardo B.

    AGC1-malate aspartate shuttle activity is critical for dopamine handling in the nigrostriatal pathway

    JOURNAL OF NEUROCHEMISTRY . 124(3): 347-362. Number of citations: 12

    [doi:10.1111/jnc.12096]

  • Fernández-Ruiz J, Sagredo O, Pazos MR, García C, Pertwee R, Mechoulam R, Martínez-Orgado J.

    Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY . 75(2): 323-333. Number of citations: 195

    [doi:10.1111/j.1365-2125.2012.04341.x]

  • Casarejos MJ, Perucho J, Gomez A, Muñoz MP, Fernandez-Estevez M, Sagredo O, Fernandez Ruiz J, Guzman M, de Yebenes JG, Mena MA.

    Natural Cannabinoids Improve Dopamine Neurotransmission and Tau and Amyloid Pathology in a Mouse Model of Tauopathy

    JOURNAL OF ALZHEIMERS DISEASE . 35(3): 525-539. Number of citations: 64

    [doi:10.3233/JAD-130050]

  • Granja AG, Carrillo-Salinas F, Pagani A, Gómez-Cañas M, Negri R, Navarrete C, Mecha M, Mestre L, Fiebich BL, Cantarero I, Calzado MA, Bellido ML, Fernandez-Ruiz J, Appendino G, Guaza C, Muñoz E.

    A Cannabigerol Quinone Alleviates Neuroinflammation in a Chronic Model of Multiple Sclerosis

    JOURNAL OF NEUROIMMUNE PHARMACOLOGY . 7(4): 1002-1016. Number of citations: 82

    [doi:10.1007/s11481-012-9399-3]