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Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

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Only original articles, editorials, guidelines.

  • Pöntinen AK, Top, Janetta, Arredondo-Alonso, Sergio, Tonkin-Hill, Gerry, Freitas, Ana R., Novais, Carla, Gladstone, Rebecca A., Pesonen, Maiju, Meneses, Rodrigo, Pesonen, Henri, Lees, John A., Jamrozy, Dorota, Bentley, Stephen D., Lanza, Val F., Torres, Carmen, Peixe, Luisa, Coque, Teresa M., Parkhill, Julian, Schurch, Anita C., Willems RJL, Corander, Jukka.

    Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era

    NATURE COMMUNICATIONS . 12(1): 1523-1523. Number of citations: 41

    [doi:10.1038/s41467-021-21749-5]

  • Aranaz-Andres, Jesus Maria, McGee-Laso, Amaranta, Galan, Juan Carlos, Canton, Rafael, Mira, Jose.

    Activities and Perceived Risk of Transmission and Spread of SARS-CoV-2 among Specialists and Residents in a Third Level University Hospital in Spain

    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH . 18(6): . Number of citations: 3

    [doi:10.3390/ijerph18062838]

  • Carrasco, Teresa, Barquin, David, Ndarabu, Adolphe, Fernandez-Alonso, Mirian, Rubio-Garrido, Marina, Carlos, Silvia, Makonda, Benit, Holguin, Africa, Reina, Gabriel.

    HCV Diagnosis and Sequencing Using Dried Blood Spots from Patients in Kinshasa (DRC): A Tool to Achieve WHO 2030 Targets

    DIAGNOSTICS . 11(3): . Number of citations: 4

    [doi:10.3390/diagnostics11030522]

  • Rodriguez-Bano, Jesus, Rossolini, Gian Maria, Schultsz, Constance, Tacconelli, Evelina, Murthy, Srinivas, Ohmagari, Norio, Holmes, Alison, Bachmann, Till, Goossens, Herman, Canton, Rafael, Roberts, Adam P, Henriques-Normark, Birgitta, Clancy, Cornelius J, Huttner, Benedikt, Fagerstedt, Patriq, Lahiri, Shawon, Kaushic, Charu, Hoffman, Steven J, Warren, Margo, Zoubiane, Ghada, Essack, Sabiha, Laxminarayan, Ramanan, Plant, Laura.

    Antimicrobial resistance research in a post-pandemic world: Insights on antimicrobial resistance research in the COVID-19 pandemic.

    JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE . 25: 5-7. Number of citations: 23

    [doi:10.1016/j.jgar.2021.02.013]

  • Bardi, Tommaso, Pintado, Vicente, Gomez-Rojo, Maria, Escudero-Sanchez, Rosa, Azzam Lopez, Amal, Diez-Remesal, Yolanda, Martinez Castro, Nilda, Ruiz-Garbajosa, Patricia, Pestaña D.

    Nosocomial infections associated to COVID-19 in the intensive care unit: clinical characteristics and outcome

    EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES . 40(3): 495-502. Number of citations: 145

    [doi:10.1007/s10096-020-04142-w]

  • Serrano-Villar S, Talavera-Rodríguez A, Gosalbes MJ, Madrid N, Pérez-Molina JA, Elliott RJ, Navia B, Lanza VF, Vallejo A, Osman M, Dronda F, Budree S, Zamora J, Gutiérrez C, Manzano M, Vivancos MJ, Ron R, Martínez-Sanz J, Herrera S, Ansa U, Moya A, Moreno S.

    Fecal microbiota transplantation in HIV: A pilot placebo-controlled study

    NATURE COMMUNICATIONS . 12(1): 1139-1139. Number of citations: 34

    [doi:10.1038/s41467-021-21472-1]

  • Hernandez-Garcia, Marta, Garcia-Castillo, Maria, Garcia-Fernandez, Sergio, Lopez-Mendoza, Diego, Diaz-Reganon, Jazmin, Romano, Joao, Passaro, Leonor, Paixão L, Canton, Rafael.

    Presence of Chromosomal crpP-like Genes Is Not Always Associated with Ciprofloxacin Resistance in Pseudomonas aeruginosa Clinical Isolates Recovered in ICU Patients from Portugal and Spain

    Microorganisms . 9(2): . Number of citations: 7

    [doi:10.3390/microorganisms9020388]

  • Viedma E, Dahdouh E, González-Alba JM, González-Bodi S, Martínez-García L, Lázaro-Perona F, Recio R, Rodríguez-Tejedor M, Folgueira MD, Cantón R, Delgado R, García-Rodríguez J, Galán JC, Mingorance J, On Behalf Of The Sars-CoV-Working Groups.

    Genomic Epidemiology of SARS-CoV-2 in Madrid, Spain, during the First Wave of the Pandemic: Fast Spread and Early Dominance by D614G Variants

    Microorganisms . 9(2): . Number of citations: 8

    [doi:10.3390/microorganisms9020454]

  • Troyano-Hernaez, Paloma, Reinosa, Roberto, Holguin, Africa.

    Evolution of SARS-CoV-2 Envelope, Membrane, Nucleocapsid, and Spike Structural Proteins from the Beginning of the Pandemic to September 2020: A Global and Regional Approach by Epidemiological Week

    VIRUSES-BASEL . 13(2): . Number of citations: 52

    [doi:10.3390/v13020243]

  • Garcia Garcia de Paredes A, Manicardi, Nicolo, Tellez, Luis, Ibañez L, Royo, Felix, Bermejo, Javier, Blanco, Carolina, Fondevila, Constantino, Fernandez Lanza, Val, Garcia-Bermejo, Laura, Falcon-Perez JM, Bañares R, Gracia-Sancho, Jordi, Albillos, Agustin.

    Molecular Profiling of Decompensated Cirrhosis by a Novel MicroRNA Signature

    Hepatology Communications . 5(2): 309-322. Number of citations: 10

    [doi:10.1002/hep4.1642]

  • Ponce-Alonso, Manuel, de la Fuente, Javier Saez, Rincon-Carlavilla, Angela, Moreno-Nunez, Paloma, Martinez-Garcia, Laura, Escudero-Sanchez, Rosa, Pintor, Rosario, Garcia-Fernandez, Sergio, Cobo, Javier.

    Impact of the coronavirus disease 2019 (COVID-19) pandemic on nosocomial Clostridioides difficile infection (Sept, 10.1017/ice.2020.454, 2020)

    INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY . 42(2): 250-250. Number of citations: 2

    [doi:10.1017/ice.2020.1380]

  • Hernandez-Garcia, Marta, Garcia-Fernandez, Sergio, Garcia-Castillo, Maria, Melo-Cristino, Jose, Pinto, Margarida F., Gonçalves E, Alves, Valquiria, Costa, Eliana, Ramalheira, Elmano, Sancho, Luisa, Diogo, Jose, Ferreira, Rui, Silva, Tania, Chaves, Catarina, Passaro, Leonor, Paixão L, Romano, Joao, Canton, Rafael, STEP study group.

    Confronting Ceftolozane-Tazobactam Susceptibility in Multidrug-Resistant Enterobacterales Isolates and Whole-Genome Sequencing Results (STEP Study)

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS . 57(2): 106259-106259. Number of citations: 7

    [doi:10.1016/j.ijantimicag.2020.106259]

  • López-Roa P, Martin-Higuera C, Ruiz-Serrano MJ, Toro C, Tato M, Simon M, Domingo D, Esteban J.

    Performance of Xpert MTB/RIF Ultra assay on respiratory and extra-respiratory samples in a high-resource setting with a low tuberculosis prevalence.

    DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE . 99(2): 115235-115235. Number of citations: 5

    [doi:10.1016/j.diagmicrobio.2020.115235]

  • Haro G, Bischofberger Valdes, C, Vicente-Guijarro, J, Diaz-Agero Perez, C, Fabregate-Fuente, M, Moreno-Nunez, P, Aranaz-Andres, J M, Research Group Covid-19 of the Hospital Universitario Ramón y Cajal.

    Decontamination of filtering facepiece respirators using a low-temperature-steam-2%-formaldehyde sterilization process during a pandemic: a safe alternative for re-use.

    JOURNAL OF HOSPITAL INFECTION . 108: 113-119. Number of citations: 3

    [doi:10.1016/j.jhin.2020.10.024]

  • Hernandez-Garcia M, Garcia-Castillo M, Garcia-Fernandez S, Melo-Cristino J, Pinto MF, Goncalves E, Alves V, Vieira AR, Ramalheira E, Sancho L, Diogo J, Ferreira R, Silva T, Chaves C, Bou G, Cercenado E, Delgado-Valverde M, Oliver A, Pitart C, Rodriguez-Lozano J, Tormo N, Romano J, Passaro L, Paixao L, Lopez-Mendoza D, Diaz-Reganon J, Canton R, STEP and SUPERIOR study groups.

    Distinct epidemiology and resistance mechanisms affecting ceftolozane/tazobactam in Pseudomonas aeruginosa isolates recovered from ICU patients in Spain and Portugal depicted by WGS

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY . 76(2): 370-379. Number of citations: 9

    [doi:10.1093/jac/dkaa430]

  • Baquero, Fernando, Levin, Bruce R..

    Proximate and ultimate causes of the bactericidal action of antibiotics

    NATURE REVIEWS MICROBIOLOGY . 19(2): 123-132. Number of citations: 80

    [doi:10.1038/s41579-020-00443-1]

  • Sainz, Talia, Delgado, Jaime, Mendez-Echevarria, Ana, Santiago, Begona, Lopez-Varela, Elisa, Aguilera-Alonso, David, Saavedra-Lozano, Jesus, Rodriguez-Fernandez, Rosa, Holguin, Africa, Navarro, Marisa L., Angeles Munoz-Fernandez M, Rivero-Calle, Irene, Solana, Maria Jose, Lopez-Herce, Jesus, Calvo, Cristina.

    The clinical relevance of the microbiome when managing paediatric infectious diseases-Narrative review

    ACTA PAEDIATRICA . 110(2): 441-449. Number of citations: 1

    [doi:10.1111/apa.15578]

  • Sanchez-Carrillo, Sergio, Ciordia, Sergio, Rojo, David, Zubeldia-Varela, Elisa, Mendez-Garcia, Celia, Martinez-Martinez, Monica, Barbas, Coral, Ruiz-Ruiz, Susana, Moya, Andres, Garriga, Maria, Salazar, Nuria, Botella-Carretero JI, Vega-Pinero, Belen, de los Reyes-Gavilan, Clara G., del Campo, Rosa, Ferrer, Manuel.

    A body weight loss- and health-promoting gut microbiota is established after bariatric surgery in individuals with severe obesity

    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS . 193: 113747-113747. Number of citations: 11

    [doi:10.1016/j.jpba.2020.113747]