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Neurodegenerative Diseases: pathogenic mechanisms

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  • Díaz-Alonso J, Guzmán M, Galve-Roperh I.

    Endocannabinoids via CB1 receptors act as neurogenic niche cues during cortical development

    PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES . 367(1607, SI): 3229-3241. Number of citations: 56

    [doi:10.1098/rstb.2011.0385]

  • Díaz-Alonso J, Aguado T, Wu CS, Palazuelos J, Hofmann C, Garcez P, Guillemot F, Lu HC, Lutz B, Guzmán M, Galve-Roperh I.

    The CB1 Cannabinoid Receptor Drives Corticospinal Motor Neuron Differentiation through the Ctip2/Satb2 Transcriptional Regulation Axis

    JOURNAL OF NEUROSCIENCE . 32(47): 16651-16665. Number of citations: 58

    [doi:10.1523/JNEUROSCI.0681-12.2012]

  • Caffarel MM, Andradas C, Pérez-Gómez E, Guzmán M, Sánchez C.

    Cannabinoids: A new hope for breast cancer therapy?

    CANCER TREATMENT REVIEWS . 38(7): 911-918. Number of citations: 69

    [doi:10.1016/j.ctrv.2012.06.005]

  • Cardinal P, Bellocchio L, Clark S, Cannich A, Klugmann M, Lutz B, Marsicano G, Cota D.

    Hypothalamic CB1 Cannabinoid Receptors Regulate Energy Balance in Mice

    Endocrinology . 153(9): 4136-4143. Number of citations: 84

    [doi:10.1210/en.2012-1405]

  • Velasco G, Sánchez C, Guzmán M.

    Towards the use of cannabinoids as antitumour agents

    NATURE REVIEWS CANCER . 12(6): 436-444. Number of citations: 228

    [doi:10.1038/nrc3247]

  • Bénard G, Massa F, Puente N, Lourenço J, Bellocchio L, Soria-Gómez E, Matias I, Delamarre A, Metna-Laurent M, Cannich A, Hebert-Chatelain E, Mulle C, Ortega-Gutiérrez S, Martín-Fontecha M, Klugmann M, Guggenhuber S, Lutz B, Gertsch J, Chaouloff F, López-Rodríguez ML, Grandes P, Rossignol R, Marsicano G.

    Mitochondrial CB1 receptors regulate neuronal energy metabolism

    NATURE NEUROSCIENCE . 15(4): 558-564. Number of citations: 316

    [doi:10.1038/nn.3053]

  • Bañez-Coronel M, Porta S, Kagerbauer B, Mateu-Huertas E, Pantano L, Ferrer I, Guzmán M, Estivill X, Martí E.

    A Pathogenic Mechanism in Huntington's Disease Involves Small CAG-Repeated RNAs with Neurotoxic Activity

    PLOS GENETICS . 8(2): . Number of citations: 126

    [doi:10.1371/journal.pgen.1002481]

  • Palazuelos J, Ortega Z, Díaz-Alonso J, Guzmán M, Galve-Roperh I.

    CB2 Cannabinoid Receptors Promote Neural Progenitor Cell Proliferation via mTORC1 Signaling

    JOURNAL OF BIOLOGICAL CHEMISTRY . 287(2): 1198-1209. Number of citations: 108

    [doi:10.1074/jbc.M111.291294]

  • Lorente M, Torres S, Salazar M, Carracedo A, Hernández-Tiedra S, Rodríguez-Fornés F, García-Taboada E, Meléndez B, Mollejo M, Campos-Martín Y, Barcia JA, Guzmán M, Velasco G.

    Stimulation of ALK by the growth factor midkine renders glioma cells resistant to autophagy-mediated cell death

    Autophagy . 7(9): 1071-1073. Number of citations: 20

    [doi:10.4161/auto.7.9.15866]

  • Fernández-Ruiz J, Moreno-Martet M, Rodríguez-Cueto C, Palomo-Garo C, Gómez-Cañas M, Valdeolivas S, Guaza C, Romero J, Guzmán M, Mechoulam R, Ramos JA.

    Prospects for cannabinoid therapies in basal ganglia disorders

    BRITISH JOURNAL OF PHARMACOLOGY . 163(7, SI): 1365-1378. Number of citations: 80

    [doi:10.1111/j.1476-5381.2011.01365.x]

  • Vara D, Salazar M, Olea-Herrero N, Guzmán M, Velasco G, Díaz-Laviada I.

    Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy

    CELL DEATH AND DIFFERENTIATION . 18(7): 1099-1111. Number of citations: 187

    [doi:10.1038/cdd.2011.32]

  • Lorente M, Torres S, Salazar M, Carracedo A, Hernández-Tiedra S, Rodríguez-Fornés F, García-Taboada E, Meléndez B, Mollejo M, Campos-Martín Y, Lakatosh SA, Barcia J, Guzmán M, Velasco G.

    Stimulation of the midkine/ALK axis renders glioma cells resistant to cannabinoid antitumoral action

    CELL DEATH AND DIFFERENTIATION . 18(6): 959-973. Number of citations: 62

    [doi:10.1038/cdd.2010.170]

  • Andradas C, Caffarel MM, Pérez-Gómez E, Salazar M, Lorente M, Velasco G, Guzmán M, Sánchez C.

    The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK

    Oncogene . 30(2): 245-252. Number of citations: 134

    [doi:10.1038/onc.2010.402]

  • Salazar M, Hernández-Tiedra S, Torres S, Lorente M, Guzmán M, Velasco G.

    DETECTING AUTOPHAGY IN RESPONSE TO ER STRESS SIGNALS IN CANCER

    METHOD ENZYMOL . 489: 297-317. Number of citations: 22

    [doi:10.1016/B978-0-12-385116-1.00017-0]

  • Torres S, Lorente M, Rodríguez-Fornés F, Hernández-Tiedra S, Salazar M, García-Taboada E, Barcia J, Guzmán M, Velasco G.

    A Combined Preclinical Therapy of Cannabinoids and Temozolomide against Glioma

    MOLECULAR CANCER THERAPEUTICS . 10(1): 90-103. Number of citations: 173

    [doi:10.1158/1535-7163.MCT-10-0688]

  • Blázquez C, Chiarlone A, Sagredo O, Aguado T, Pazos MR, Resel E, Palazuelos J, Julien B, Salazar M, Börner C, Benito C, Carrasco C, Diez-Zaera M, Paoletti P, Díaz-Hernández M, Ruiz C, Sendtner M, Lucas JJ, de Yébenes JG, Marsicano G, Monory K, Lutz B, Romero J, Alberch J, Ginés S, Kraus J, Fernández-Ruiz J, Galve-Roperh I, Guzmán M.

    Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease

    Brain . 134(1): 119-136. Number of citations: 135

    [doi:10.1093/brain/awq278]

  • Caffarel MM, Andradas C, Mira E, Pérez-Gómez E, Cerutti C, Moreno-Bueno G, Flores JM, García-Real I, Palacios J, Mañes S, Guzmán M, Sánchez C.

    Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition

    MOLECULAR CANCER . 9: 196-196. Number of citations: 105

    [doi:10.1186/1476-4598-9-196]

  • Barana A, Amorós I, Caballero R, Gómez R, Osuna L, Lillo MP, Blázquez C, Guzmán M, Delpón E, Tamargo J.

    Endocannabinoids and cannabinoid analogues block cardiac hKv1.5 channels in a cannabinoid receptor-independent manner

    CARDIOVASCULAR RESEARCH . 85(1): 56-67. Number of citations: 36

    [doi:10.1093/cvr/cvp284]