Neurodegenerative Diseases: pathogenic mechanisms

2025 Activity indicators

6 competitive national public projects: ISCIII, MICINN, CIBERNED, MICIU
1 private project led
1 competitive HR contract
4 publications
FI: 52.90
Publications in Q1: 3 (75%)
Publications in D1: 3 (75%)
Project evaluators: 1 PI
Editorial committee members: 2 PI
10-month stay at a national center:
- Severo Ochoa Center for Molecular Biology (CBMSO)
1 visiting researcher and 3-month stay:
- National Autonomous University of Mexico (UNAM)

Milestones

Dudek KA, Paton SEJ, Binder LB, Collignon A, Dion-Albert L, Cadoret A, Lebel M, Lavoie O, Bouchard J, Kaufmann FN, Clavet-Fournier V, Manca C, Guzmán M, Campbell M, Turecki G, Mechawar N, Flamand N, Lavoie-Cardinal F, Silvestri C, Di Marzo V, Menard C. Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood-brain barrier alterations. Nat Neurosci. 2025 Apr;28(4):766-782. doi: 10.1038/s41593-025-01891-9.
Di Franco N, Bengoetxea de Tena I, Sanchez-Ruiz A, PeredaVelarde A, Enfedaque F, Gónzalez-Arias C, Rio LMM, Bortolozzi A, Rodriguez-Puertas R, Costas-Insua C, MolinaPorcel L, Vazquez-Oliver A, Ozaita A, Guzmán M, Perea G, Ginés S. Restoration of CB1 receptor function in hippocampal GABAergic neurons rescues memory defi cits in Huntington's disease models. Transl Neurodegener. 2025 Aug 25;14(1):44. doi: 10.1186/s40035-025-00500-w.
Simón-Sánchez S, den Boon F, García-Rincón D, Skrempou G, Paraíso-Luna J, Aguilera A, Nieto M, Werkman TR, Guzmán M, Chameau P, Galve-Roperh I. Prenatal Downregulation of CB1 Cannabinoid Receptors in the Mouse Prefrontal Cortex Disrupts Cortical Lamination and Induces a Transcriptional Signature Associated with Social Interaction Defi cits. J Neurosci. 2025 Oct 15;45(42):e0120252025. doi: 10.1523/ JNEUROSCI.0120-25.2025.
Zhao Z, Xu W, Feng EY, Cao S, Hermoso-López A, Peña-Vega P, Lloyd HC, Porter AKD, Guzmán M, Zheng N, Woo CM. PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates. Nat Chem Biol. 2026; 22(5):802-812. doi: 10.1038/ s41589-025-02106-9.
Start of the project "Ubiquitination of the CB1 receptor: a new molecular mechanism of cannabinoid tolerance?" (PID2024-156496OB-I00), led by Prof. Guzmán, within the call "Knowledge Generation Projects 2024" funded by MICIU.

Bibliometrics

	Articles	Accum. IF	Mean IF	Articles QI or Q2	% in Q1 or Q2	Articles D1	% in D1
2021	6	36.42	6.07	5	83	2	33
2022	2	13.23	6.61	2	100	1	50
2023	7	76.20	10.89	7	100	3	43
2024	5	30.80	6.16	5	100	2	40
2025	4	52.90	13.23	4	100	3	75
	24	209.55	8.59	23	96	11	46