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Neurodegenerative diseases: pathogenic mechanisms

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  • Maroto IB, Costas-Insua C, Montero-Fernández C, Hermoso-López A, Lebouc M, Bajo-Grañeras R, Álvaro-Blázquez A, Blázquez C, Cannich A, Marsicano G, Martín R, Baufreton J, Rodríguez-Crespo I, Bellocchio L, Guzmán M.

    GAP43 Located on Corticostriatal Terminals Restrains Novelty-Induced Hyperactivity in Mice.

    JOURNAL OF NEUROSCIENCE . 44(39): .

    [doi:10.1523/JNEUROSCI.0701-24.2024]

  • Quintero JM, Diaz LE, Galve-Roperh I, Bustos RH, Leon MX, Beltran S, Dodd S.

    The endocannabinoid system as a therapeutic target in neuropathic pain: a review.

    EXPERT OPINION ON THERAPEUTIC TARGETS . 28(9): 739-755.

    [doi:10.1080/14728222.2024.2407824]

  • Costas-Insua C, Hermoso-López A, Moreno E, Montero-Fernández C, Álvaro-Blázquez A, Maroto IB, Sánchez-Ruiz A, Diez-Alarcia R, Blázquez C, Morales P, Canela EI, Casadó V, Urigüen L, Perea G, Bellocchio L, Rodríguez-Crespo I, Guzmán M.

    The CB(1) receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls.

    EMBO MOLECULAR MEDICINE . 16(4): 755-783.

    [doi:10.1038/s44321-024-00054-w]

  • Tundidor I, Seijo-Vila M, Blasco-Benito S, Rubert-Hernández M, Moreno-Bueno G, Bindila L, de la Rosa RF, Guzmán M, Sánchez C, Pérez-Gómez E.

    Fatty acid amide hydrolase drives adult mammary gland development by promoting luminal cell differentiation.

    Cell death discovery . 10(1): 12-12.

    [doi:10.1038/s41420-023-01788-1]

  • Maroto IB, Moreno E, Costas-Insua C, Merino-Gracia J, Diez-Alarcia R, Álvaro-Blázquez A, Canales Á, Canela EI, Casadó V, Urigüen L, Rodríguez-Crespo I, Guzmán M.

    Selective inhibition of cannabinoid CB(1) receptor-evoked signalling by the interacting protein GAP43.

    Neuropharmacology . 240: 109712-109712.

    [doi:10.1016/j.neuropharm.2023.109712]

  • Espina M, Di Franco N, Brañas-Navarro M, Navarro IR, Brito V, Lopez-Molina L, Costas-Insua C, Guzmán M, Ginés S.

    The GRP78-PERK axis contributes to memory and synaptic impairments in Huntington's disease R6/1 mice.

    NEUROBIOLOGY OF DISEASE . 184: 106225-106225.

    [doi:10.1016/j.nbd.2023.106225]

  • Tundidor I, Seijo-Vila M, Blasco-Benito S, Rubert-Hernández M, Adámez S, Andradas C, Manzano S, Álvarez-López I, Sarasqueta C, Villa-Morales M, González-Lois C, Ramírez-Medina E, Almoguera B, Sánchez-López AJ, Bindila L, Hamann S, Arnold N, Röcken C, Heras-Murillo I, Sancho D, Moreno-Bueno G, Caffarel MM, Guzmán M, Sánchez C, Pérez-Gómez E.

    Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer.

    NATURE COMMUNICATIONS . 14(1): 3130-3130.

    [doi:10.1038/s41467-023-38750-9]

  • Costas-Insua C, Seijo-Vila M, Blázquez C, Blasco-Benito S, Rodríguez-Baena FJ, Marsicano G, Pérez-Gómez E, Sánchez C, Sánchez-Laorden B, Guzmán M.

    Neuronal Cannabinoid CB(1) Receptors Suppress the Growth of Melanoma Brain Metastases by Inhibiting Glutamatergic Signalling.

    Cancers . 15(9): .

    [doi:10.3390/cancers15092439]

  • Maroto IB, Costas-Insua C, Berthoux C, Moreno E, Ruiz-Calvo A, Montero-Fernández C, Macías-Camero A, Martín R, García-Font N, Sánchez-Prieto J, Marsicano G, Bellocchio L, Canela EI, Casadó V, Galve-Roperh I, Núñez Á, Fernández de Sevilla D, Rodríguez-Crespo I, Castillo PE, Guzmán M.

    Control of a hippocampal recurrent excitatory circuit by cannabinoid receptor-interacting protein Gap43.

    NATURE COMMUNICATIONS . 14(1): 2303-2303. Number of citations: 1

    [doi:10.1038/s41467-023-38026-2]

  • Costas-Insua C, Guzmán M.

    Endocannabinoid signaling in glioma

    Glia . 71(1): 127-138. Number of citations: 3

    [doi:10.1002/glia.24173]

  • Manterola A, Chara JC, Aguado T, Palazuelos J, Matute C, Mato S.

    Cannabinoid CB(1) receptor expression in oligodendrocyte progenitors of the hippocampus revealed by the NG2-EYFP-knockin mouse.

    FRONTIERS IN NEUROANATOMY . 16: 1030060-1030060.

    [doi:10.3389/fnana.2022.1030060]

  • Sánchez-de la Torre A, Aguado T, Huerga-Gómez A, Santamaría S, Gentile A, Chara JC, Matute C, Monory K, Mato S, Guzmán M, Lutz B, Galve-Roperh I, Palazuelos J.

    Cannabinoid CB(1) receptor gene inactivation in oligodendrocyte precursors disrupts oligodendrogenesis and myelination in mice.

    CELL DEATH & DISEASE . 13(7): 585-585. Number of citations: 1

    [doi:10.1038/s41419-022-05032-z]

  • McAllister SD, Abood ME, Califano J, Guzmán M.

    Cannabinoid Cancer Biology and Prevention.

    Journal of the National Cancer Institute. Monographs . 2021(58): 99-106.

    [doi:10.1093/jncimonographs/lgab008]

  • Gómez-Almería M, Burgaz S, Costas-Insua C, Rodríguez-Cueto C, Santos-García I, Rodríguez-Crespo I, García C, Guzmán M, de Lago E, Fernández-Ruiz J.

    BiP Heterozigosity Aggravates Pathological Deterioration in Experimental Amyotrophic Lateral Sclerosis

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES . 22(22): . Number of citations: 2

    [doi:10.3390/ijms222212533]

  • Aguado, Tania, Huerga-Gomez, Alba, Sanchez-de la Torre, Anibal, Resel, Eva, Chara, Juan Carlos, Matute, Carlos, Mato, Susana, Galve-Roperh, Ismael, Guzman, Manuel, Palazuelos, Javier.

    Delta(9)-Tetrahydrocannabinol promotes functional remyelination in the mouse brain

    BRITISH JOURNAL OF PHARMACOLOGY . 178(20): 4176-4192. Number of citations: 6

    [doi:10.1111/bph.15608]

  • Costas-Insua C, Moreno E, Maroto IB, Ruiz-Calvo A, Bajo-Grañeras R, Martín-Gutiérrez D, Diez-Alarcia R, Vilaró MT, Cortés R, García-Font N, Martín R, Espina M, Botta J, Ginés S, McCormick PJ, Sánchez-Prieto J, Galve-Roperh I, Mengod G, Urigüen L, Marsicano G, Bellocchio L, Canela EI, Casadó V, Rodríguez-Crespo I, Guzmán M.

    Identification of BiP as a CB(1) receptor-interacting protein that fine-tunes cannabinoid signaling in the mouse brain.

    JOURNAL OF NEUROSCIENCE . 41(38): 7924-7941. Number of citations: 7

    [doi:10.1523/JNEUROSCI.0821-21.2021]

  • Maglio, Laura E., Noriega-Prieto, Jose A., Maroto, Irene B., Martin-Cortecero, Jesus, Muñoz-Callejas A, Callejo-Mostoles, Marta, Fernandez de Sevilla, David.

    IGF-1 facilitates extinction of conditioned fear

    ELIFE . 10: . Number of citations: 12

    [doi:10.7554/eLife.67267]

  • Huerga-Gomez, Alba, Aguado, Tania, Sanchez-de la Torre, Anibal, Bernal-Chico, Ana, Matute, Carlos, Mato, Susana, Guzman, Manuel, Galve-Roperh, Ismael, Palazuelos, Javier.

    Delta(9)-Tetrahydrocannabinol promotes oligodendrocyte development and CNS myelination in vivo

    Glia . 69(3): 532-545. Number of citations: 15

    [doi:10.1002/glia.23911]