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Neurodegenerative diseases: pathogenic mechanisms

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  • Soria-Gómez E, Massa F, Bellocchio L, Rueda-Orozco PE, Ciofi P, Cota D, Oliet SH, Prospéro-García O, Marsicano G.

    CANNABINOID TYPE-1 RECEPTORS IN THE PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS INHIBIT STIMULATED FOOD INTAKE

    Neuroscience . 263: 46-53. Number of citations: 23

    [doi:10.1016/j.neuroscience.2014.01.005]

  • Soria-Gómez E, Bellocchio L, Reguero L, Lepousez G, Martin C, Bendahmane M, Ruehle S, Remmers F, Desprez T, Matias I, Wiesner T, Cannich A, Nissant A, Wadleigh A, Pape HC, Chiarlone AP, Quarta C, Verrier D, Vincent P, Massa F, Lutz B, Guzmán M, Gurden H, Ferreira G, Lledo PM, Grandes P, Marsicano G.

    The endocannabinoid system controls food intake via olfactory processes

    NATURE NEUROSCIENCE . 17(3): 407-415. Number of citations: 157

    [doi:10.1038/nn.3647]

  • Vallée M, Vitiello S, Bellocchio L, Hébert-Chatelain E, Monlezun S, Martin-Garcia E, Kasanetz F, Baillie GL, Panin F, Cathala A, Roullot-Lacarrière V, Fabre S, Hurst DP, Lynch DL, Shore DM, Deroche-Gamonet V, Spampinato U, Revest JM, Maldonado R, Reggio PH, Ross RA, Marsicano G, Piazza PV.

    Pregnenolone Can Protect the Brain from Cannabis Intoxication

    Science . 343(6166): 94-98. Number of citations: 181

    [doi:10.1126/science.1243985]

  • Yan Y, Serra V, Prudkin L, Scaltriti M, Murli S, Rodríguez O, Guzman M, Sampath D, Nannini M, Xiao Y, Wagle MC, Wu JQ, Wongchenko M, Hampton G, Ramakrishnan V, Lackner MR, Saura C, Roda D, Cervantes A, Tabernero J, Patel P, Baselga J.

    Evaluation and Clinical Analyses of Downstream Targets of the Akt Inhibitor GDC-0068

    Clinical cancer research : an official journal of the American Association for Cancer Research . 19(24): 6976-6986. Number of citations: 59

    [doi:10.1158/1078-0432.CCR-13-0978]

  • Bosier B, Bellocchio L, Metna-Laurent M, Soria-Gomez E, Matias I, Hebert-Chatelain E, Cannich A, Maitre M, Leste-Lasserre T, Cardinal P, Mendizabal-Zubiaga J, Canduela MJ, Reguero L, Hermans E, Grandes P, Cota D, Marsicano G.

    Astroglial CB1 cannabinoid receptors regulate leptin signaling in mouse brain astrocytes

    Molecular metabolism . 2(4): 393-404. Number of citations: 57

    [doi:10.1016/j.molmet.2013.08.001]

  • Ostapchenko VG, Beraldo FH, Guimarães AL, Mishra S, Guzman M, Fan J, Martins VR, Prado VF, Prado MA.

    Increased prion protein processing and expression of metabotropic glutamate receptor 1 in a mouse model of Alzheimer's disease

    JOURNAL OF NEUROCHEMISTRY . 127(3): 415-425. Number of citations: 32

    [doi:10.1111/jnc.12296]

  • Galve-Roperh I, Chiurchiù V, Díaz-Alonso J, Bari M, Guzmán M, Maccarrone M.

    Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation

    PROGRESS IN LIPID RESEARCH . 52(4): 633-650. Number of citations: 174

    [doi:10.1016/j.plipres.2013.05.004]

  • Salazar M, Lorente M, García-Taboada E, Hernández-Tiedra S, Davila D, Francis SE, Guzmán M, Kiss-Toth E, Velasco G.

    The pseudokinase tribbles homologue-3 plays a crucial role in cannabinoid anticancer action

    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS . 1831(10, SI): 1573-1578. Number of citations: 41

    [doi:10.1016/j.bbalip.2013.03.014]

  • Bishay P, Häussler A, Lim HY, Oertel B, Galve-Roperh I, Ferreirós N, Tegeder I.

    Anandamide deficiency and heightened neuropathic pain in aged mice

    Neuropharmacology . 71: 204-215. Number of citations: 20

    [doi:10.1016/j.neuropharm.2013.03.021]

  • Campos AC, Ortega Z, Palazuelos J, Fogaça MV, Aguiar DC, Díaz-Alonso J, Ortega-Gutiérrez S, Vázquez-Villa H, Moreira FA, Guzmán M, Galve-Roperh I, Guimarães FS.

    The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY . 16(6): 1407-1419. Number of citations: 155

    [doi:10.1017/S1461145712001502]

  • Pérez-Gómez E, Andradas C, Flores JM, Quintanilla M, Paramio JM, Guzmán M, Sánchez C.

    The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas

    Oncogene . 32(20): 2534-2542. Number of citations: 60

    [doi:10.1038/onc.2012.278]

  • Fogaça MV, Galve-Roperh I, Guimarães FS, Campos AC.

    Cannabinoids, Neurogenesis and Antidepressant Drugs: Is there a Link?

    CURRENT NEUROPHARMACOLOGY . 11(3): 263-275. Number of citations: 14

    [doi:10.2174/1570159X11311030003]

  • Bellocchio L, Soria-Gómez E, Quarta C, Metna-Laurent M, Cardinal P, Binder E, Cannich A, Delamarre A, Häring M, Martín-Fontecha M, Vega D, Leste-Lasserre T, Bartsch D, Monory K, Lutz B, Chaouloff F, Pagotto U, Guzman M, Cota D, Marsicano G.

    Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB1 receptor blockade

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA . 110(12): 4786-4791. Number of citations: 76

    [doi:10.1073/pnas.1218573110]

  • Hernán Pérez de la Ossa D, Lorente M, Gil-Alegre ME, Torres S, García-Taboada E, Aberturas Mdel R, Molpeceres J, Velasco G, Torres-Suárez AI.

    Local Delivery of Cannabinoid-Loaded Microparticles Inhibits Tumor Growth in a Murine Xenograft Model of Glioblastoma Multiforme

    Plos One . 8(1): . Number of citations: 56

    [doi:10.1371/journal.pone.0054795]

  • Casarejos MJ, Perucho J, Gomez A, Muñoz MP, Fernandez-Estevez M, Sagredo O, Fernandez Ruiz J, Guzman M, de Yebenes JG, Mena MA.

    Natural Cannabinoids Improve Dopamine Neurotransmission and Tau and Amyloid Pathology in a Mouse Model of Tauopathy

    JOURNAL OF ALZHEIMERS DISEASE . 35(3): 525-539. Number of citations: 64

    [doi:10.3233/JAD-130050]

  • Pamplona FA, Ferreira J, Menezes de Lima O, Duarte FS, Bento AF, Forner S, Villarinho JG, Bellocchio L, Bellochio L, Wotjak CT, Lerner R, Monory K, Lutz B, Canetti C, Matias I, Calixto JB, Marsicano G, Guimarães MZ, Takahashi RN.

    Anti-inflammatory lipoxin A(4) is an endogenous allosteric enhancer of CB1 cannabinoid receptor

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA . 109(51): 21134-21139. Number of citations: 128

    [doi:10.1073/pnas.1202906109]

  • Díaz-Alonso J, Guzmán M, Galve-Roperh I.

    Endocannabinoids via CB1 receptors act as neurogenic niche cues during cortical development

    PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES . 367(1607, SI): 3229-3241. Number of citations: 56

    [doi:10.1098/rstb.2011.0385]

  • Díaz-Alonso J, Aguado T, Wu CS, Palazuelos J, Hofmann C, Garcez P, Guillemot F, Lu HC, Lutz B, Guzmán M, Galve-Roperh I.

    The CB1 Cannabinoid Receptor Drives Corticospinal Motor Neuron Differentiation through the Ctip2/Satb2 Transcriptional Regulation Axis

    JOURNAL OF NEUROSCIENCE . 32(47): 16651-16665. Number of citations: 58

    [doi:10.1523/JNEUROSCI.0681-12.2012]