1. Home
  2. Research
  3. Research Groups
  4. Neurodegenerative diseases: pathogenic mechanisms

Neurodegenerative diseases: pathogenic mechanisms

Search for publications

Only original articles, editorials, guidelines.

  • Paraiso-Luna, Juan, Aguareles, Jose, Martin, Ricardo, Ayo-Martin, Ane C, Simon-Sanchez, Samuel, Garcia-Rincon, Daniel, Costas-Insua, Carlos, Garcia-Taboada, Elena, de Salas-Quiroga, Adan, Diaz-Alonso, Javier, Liste, Isabel, Sanchez-Prieto, Jose, Cappello, Silvia, Guzman, Manuel, Galve-Roperh, Ismael.

    Endocannabinoid signalling in stem cells and cerebral organoids drives differentiation to deep layer projection neurons via CB1 receptors.

    DEVELOPMENT . 147(24): . Number of citations: 6

    [doi:10.1242/dev.192161]

  • Blazquez, Cristina, Ruiz-Calvo, Andrea, Bajo-Graneras, Raquel, Baufreton, Jerome M., Resel, Eva, Varilh, Marjorie, Pagano Zottola, Antonio C., Mariani, Yamuna, Cannich, Astrid, Rodriguez-Navarro, Jose A., Marsicano, Giovanni, Galve-Roperh, Ismael, Bellocchio, Luigi, Guzman, Manuel.

    Cannabinoid-induced motor dysfunctionviaautophagy inhibition

    Autophagy . 16(12): 2289-2291. Number of citations: 1

    [doi:10.1080/15548627.2020.1827560]

  • Bartoll, Adrian, Toledano-Zaragoza, Ana, Casas, Josefina, Guzman, Manuel, Schuchman, Edward H., Ledesma, Maria Dolores.

    Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling

    EMBO MOLECULAR MEDICINE . 12(11): . Number of citations: 11

    [doi:10.15252/emmm.201911776]

  • Blazquez, Cristina, Ruiz-Calvo, Andrea, Bajo-Graneras, Raquel, Baufreton, Jerome M., Resel, Eva, Varilh, Marjorie, Pagano Zottola AC, Mariani, Yamuna, Cannich, Astrid, Rodriguez-Navarro, Jose A., Marsicano, Giovanni, Galve-Roperh, Ismael, Bellocchio, Luigi, Guzman, Manuel.

    Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination

    ELIFE . 9: . Number of citations: 5

    [doi:10.7554/eLife.56811]

  • Jimenez-Blasco, Daniel, Busquets-Garcia, Arnau, Hebert-Chatelain, Etienne, Serrat, Roman, Vicente-Gutierrez, Carlos, Ioannidou, Christina, Gomez-Sotres, Paula, Lopez-Fabuel, Irene, Resch-Beusher, Monica, Resel, Eva, Arnouil, Dorian, Saraswat, Dave, Varilh, Marjorie, Cannich, Astrid, Julio-Kalajzic, Francisca, Bonilla-Del Rio, Itziar, Almeida, Angeles, Puente, Nagore, Achicallende, Svein, Lopez-Rodriguez, Maria-Luz, Jolle, Charlotte, Deglon, Nicole, Pellerin, Luc, Josephine, Charlene, Bonvento, Gilles, Panatier, Aude, Lutz, Beat, Piazza, Pier-Vincenzo, Guzman, Manuel, Bellocchio, Luigi, Bouzier-Sore, Anne-Karine, Grandes, Pedro, Bolaños JP, Marsicano, Giovanni.

    Glucose metabolism links astroglial mitochondria to cannabinoid effects

    Nature . 583(7817): 603-608. Number of citations: 126

    [doi:10.1038/s41586-020-2470-y]

  • Fernandez-Ruiz, Javier, Galve-Roperh, Ismael, Sagredo, Onintza, Guzman, Manuel.

    Possible therapeutic applications of cannabis in the neuropsychopharmacology field

    EUROPEAN NEUROPSYCHOPHARMACOLOGY . 36: 217-234. Number of citations: 19

    [doi:10.1016/j.euroneuro.2020.01.013]

  • Moreno-Delgado D, Puigdellívol M, Moreno E, Rodríguez-Ruiz M, Botta J, Gasperini P, Chiarlone A, Howell LA, Scarselli M, Casadó V, Cortés A, Ferré S, Guzmán M, Lluís C, Alberch J, Canela EI, Ginés S, McCormick PJ.

    Modulation of dopamine D 1 receptors via histamine H 3 receptors is a novel therapeutic target for Huntington's disease.

    ELIFE . 9: . Number of citations: 16

    [doi:10.7554/eLife.51093]

  • Navas-Olive, Andrea, Valero, Manuel, Jurado-Parras, Teresa, de Salas-Quiroga, Adan, Averkin, Robert G., Gambino, Giuditta, Cid, Elena, de la Prida, Liset M..

    Multimodal determinants of phase-locked dynamics across deep-superficial hippocampal sublayers during theta oscillations

    NATURE COMMUNICATIONS . 11(1): 2217-2217. Number of citations: 31

    [doi:10.1038/s41467-020-15840-6]

  • de Salas-Quiroga, Adan, Garcia-Rincon, Daniel, Gomez-Dominguez, Daniel, Valero, Manuel, Simon-Sanchez, Samuel, Paraiso-Luna, Juan, Aguareles, Jose, Pujadas, Mitona, Muguruza, Carolina, Callado, Luis F., Lutz, Beat, Guzman, Manuel, de la Prida LM, Galve-Roperh, Ismael.

    Long-term hippocampal interneuronopathy drives sex-dimorphic spatial memory impairment induced by prenatal THC exposure

    NEUROPSYCHOPHARMACOLOGY . 45(5): 877-886. Number of citations: 36

    [doi:10.1038/s41386-020-0621-3]

  • Abrams, Donald I., Guzman, Manuel.

    Can Cannabis Cure Cancer?

    JAMA Oncology . 6(3): 323-324. Number of citations: 9

    [doi:10.1001/jamaoncol.2019.5983]

  • Ruiz-Calvo A, Bajo-Grañeras R, Maroto IB, Zian D, Grabner GF, García-Taboada E, Resel E, Zechner R, Zimmermann R, Ortega-Gutiérrez S, Galve-Roperh I, Bellocchio L, Guzmán M.

    Astroglial monoacylglycerol lipase controls mutant huntingtin-induced damage of striatal neurons.

    Neuropharmacology . 150: 134-144. Number of citations: 11

    [doi:10.1016/j.neuropharm.2019.03.027]

  • Aguareles J, Paraíso-Luna J, Palomares B, Bajo-Grañeras R, Navarrete C, Ruiz-Calvo A, García-Rincón D, García-Taboada E, Guzmán M, Muñoz E, Galve-Roperh I.

    Oral administration of the cannabigerol derivative VCE-003.2 promotes subventricular zone neurogenesis and protects against mutant huntingtin-induced neurodegeneration.

    Translational Neurodegeneration . 8: 9-9. Number of citations: 17

    [doi:10.1186/s40035-019-0148-x]

  • Blasco-Benito S, Moreno E, Seijo-Vila M, Tundidor I, Andradas C, Caffarel MM, Caro-Villalobos M, Urigüen L, Diez-Alarcia R, Moreno-Bueno G, Hernández L, Manso L, Homar-Ruano P, McCormick PJ, Bibic L, Bernadó-Morales C, Arribas J, Canals M, Casadó V, Canela EI, Guzmán M, Pérez-Gómez E, Sánchez C.

    Therapeutic targeting of HER2-CB 2 R heteromers in HER2-positive breast cancer.

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA . 116(9): 3863-3872. Number of citations: 30

    [doi:10.1073/pnas.1815034116]

  • García-Rincón D, Díaz-Alonso J, Paraíso-Luna J, Ortega Z, Aguareles J, de Salas-Quiroga A, Jou C, de Prada I, Martínez-Cerdeño V, Aronica E, Guzmán M, Pérez-Jiménez MÁ, Galve-Roperh I.

    Contribution of Altered Endocannabinoid System to Overactive mTORC1 Signaling in Focal Cortical Dysplasia.

    FRONTIERS IN PHARMACOLOGY . 9: 1508-1508. Number of citations: 6

    [doi:10.3389/fphar.2018.01508]

  • Roig-Puiggros S, Vigouroux RJ, Beckman D, Bocai NI, Chiou B, Davimes J, Gomez G, Grassi S, Hoque A, Karikari TK, Kiffer F, Lopez M, Lunghi G, Mazengenya P, Meier S, Olguín-Albuerne M, Oliveira MM, Paraíso-Luna J, Pradhan J, Radiske A, Ramos-Hryb AB, Ribeiro MC, Schellino R, Selles MC, Singh S, Theotokis P, Chédotal A.

    Construction and reconstruction of brain circuits: normal and pathological axon guidance.

    JOURNAL OF NEUROCHEMISTRY . 153(1): 10-32. Number of citations: 10

    [doi:10.1111/jnc.14900]

  • Sagredo O, Palazuelos J, Gutierrez-Rodriguez A, Satta V, Galve-Roperh I, Martínez-Orgado J.

    Cannabinoid signalling in the immature brain: Encephalopathies and neurodevelopmental disorders.

    BIOCHEMICAL PHARMACOLOGY . 157: 85-96. Number of citations: 9

    [doi:10.1016/j.bcp.2018.08.014]

  • Blasco-Benito S, Seijo-Vila M, Caro-Villalobos M, Tundidor I, Andradas C, García-Taboada E, Wade J, Smith S, Guzmán M, Pérez-Gómez E, Gordon M, Sánchez C.

    Appraising the entourage effect: Antitumor action of a pure cannabinoid versus a botanical drug preparation in preclinical models of breast cancer.

    BIOCHEMICAL PHARMACOLOGY . 157: 285-293.

    [doi:10.1016/j.bcp.2018.06.025]

  • Guzmán M.

    Cannabis for the Management of Cancer Symptoms: THC Version 2.0?

    Cannabis And Cannabinoid Research . 3(1): 117-119.

    [doi:10.1089/can.2018.0009]