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Biomarkers and Personalized Approach to Cancer Group (BioPAC)

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  • Friederich MW, Timal S, Powell CA, Dallabona C, Kurolap A, Palacios-Zambrano S, Bratkovic D, Derks TGJ, Bick D, Bouman K, Chatfield KC, Damouny-Naoum N, Dishop MK, Falik-Zaccai TC, Fares F, Fedida A, Ferrero I, Gallagher RC, Garesse R, Gilberti M, González C, Gowan K, Habib C, Halligan RK, Kalfon L, Knight K, Lefeber D, Mamblona L, Mandel H, Mory A, Ottoson J, Paperna T, Pruijn GJM, Rebelo-Guiomar PF, Saada A, Sainz B, Salvemini H, Schoots MH, Smeitink JA, Szukszto MJ, Ter Horst HJ, van den Brandt F, van Spronsen FJ, Veltman JA, Wartchow E, Wintjes LT, Zohar Y, Fernández-Moreno MA, Baris HN, Donnini C, Minczuk M, Rodenburg RJ, Van Hove JLK.

    Pathogenic variants in glutamyl-tRNA Gln amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder.

    NATURE COMMUNICATIONS . 9(1): 4065-4065. Number of citations: 20

    [doi:10.1038/s41467-018-06250-w]

  • Zagorac, Sladjana, Garcia-Bermejo, Laura, Sainz, Bruno, Jr..

    The Epigenetic Landscape of Pancreatic Cancer Stem Cells

    Epigenomes . 2(2): . Number of citations: 5

    [doi:10.3390/epigenomes2020010]

  • Alguacil-Núñez C, Ferrer-Ortiz I, García-Verdú E, López-Pirez P, Llorente-Cortijo IM, Sainz B.

    Current perspectives on the crosstalk between lung cancer stem cells and cancer-associated fibroblasts.

    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY . 125: 102-110. Number of citations: 17

    [doi:10.1016/j.critrevonc.2018.02.015]

  • González I, Earl J, Fernández LJ, Sainz B, Pinto A, Monge R, Alcalá S, Castillejo A, Soto JL, Carrato A.

    A Label Free Disposable Device for Rapid Isolation of Rare Tumor Cells from Blood by Ultrasounds.

    MICROMACHINES . 9(3): . Number of citations: 13

    [doi:10.3390/mi9030129]

  • Djurec M, Graña O, Lee A, Troulé K, Espinet E, Cabras L, Navas C, Blasco MT, Martín-Díaz L, Burdiel M, Li J, Liu Z, Vallespinós M, Sanchez-Bueno F, Sprick MR, Trumpp A, Sainz B, Al-Shahrour F, Rabadan R, Guerra C, Barbacid M.

    Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors.

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA . 115(6): 1147-1156. Number of citations: 79

    [doi:10.1073/pnas.1717802115]

  • Valle S, Martin-Hijano L, Alcalá S, Alonso-Nocelo M, Sainz B.

    The Ever-Evolving Concept of the Cancer Stem Cell in Pancreatic Cancer.

    Cancers . 10(2): . Number of citations: 65

    [doi:10.3390/cancers10020033]

  • D'Errico G, Machado HL, Sainz B.

    A current perspective on cancer immune therapy: step-by-step approach to constructing the magic bullet.

    Clinical And Translational Medicine . 6(1): 3-3. Number of citations: 44

    [doi:10.1186/s40169-016-0130-5]

  • da Silva IL, Montero-Montero L, Martín-Villar E, Martin-Pérez J, Sainz B, Renart J, Toscano Simões R, Soares Veloso É, Salviano Teixeira C, de Oliveira MC, Ferreira E, Quintanilla M.

    Reduced expression of the murine HLA-G homolog Qa-2 is associated with malignancy, epithelial-mesenchymal transition and stemness in breast cancer cells.

    SCIENTIFIC REPORTS . 7(1): 6276-6276. Number of citations: 8

    [doi:10.1038/s41598-017-06528-x]

  • López-Gómez M, Casado E, Muñoz M, Alcalá S, Moreno-Rubio J, D'Errico G, Jiménez-Gordo AM, Salinas S, Sainz B.

    Current evidence for cancer stem cells in gastrointestinal tumors and future research perspectives.

    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY . 107: 54-71. Number of citations: 3

    [doi:10.1016/j.critrevonc.2016.08.006]

  • Zagorac S, Alcala S, Fernandez Bayon G, Bou Kheir T, Schoenhals M, González-Neira A, Fernandez Fraga M, Aicher A, Heeschen C, Sainz B.

    DNMT1 Inhibition Reprograms Pancreatic Cancer Stem Cells via Upregulation of the miR-17-92 Cluster

    CANCER RESEARCH . 76(15): 4546-4558. Number of citations: 71

    [doi:10.1158/0008-5472.CAN-15-3268]

  • Sancho P, Alcala S, Usachov V, Hermann PC, Sainz B.

    The ever-changing landscape of pancreatic cancer stem cells.

    Pancreatology . 16(4): 489-496. Number of citations: 19

    [doi:10.1016/j.pan.2016.04.004]

  • Sainz B, Carron E, Vallespinós M, Machado HL.

    Cancer Stem Cells and Macrophages: Implications in Tumor Biology and Therapeutic Strategies

    MEDIATORS OF INFLAMMATION . 2016: 9012369-9012369. Number of citations: 66

    [doi:10.1155/2016/9012369]

  • Cioffi M, Vallespinos-Serrano M, Trabulo SM, Fernandez-Marcos PJ, Firment AN, Vazquez BN, Vieira CR, Mulero F, Camara JA, Cronin UP, Perez M, Soriano J, G Galvez B, Castells-Garcia A, Haage V, Raj D, Megias D, Hahn S, Serrano L, Moon A, Aicher A, Heeschen C.

    MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3

    CELL REPORTS . 12(10): 1594-1605. Number of citations: 79

    [doi:10.1016/j.celrep.2015.08.006]

  • Hohwieler M, Illing A, Hermann PC, Mayer T, Stockmann M, Perkhofer L, Eiseler T, Antony JS, Müller M, Renz S, Kuo CC, Lin Q, Sendler M, Breunig M, Kleiderman SM, Lechel A, Zenker M, Leichsenring M, Rosendahl J, Zenke M, Sainz B, Mayerle J, Costa IG, Seufferlein T, Kormann M, Wagner M, Liebau S, Kleger A.

    Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling.

    Gut . : .

    [doi:10.1136/gutjnl-2016-312423]

  • Martinelli P, Carrillo-de Santa Pau E, Cox T, Sainz B, Dusetti N, Greenhalf W, Rinaldi L, Costello E, Ghaneh P, Malats N, Büchler M, Pajic M, Biankin AV, Iovanna J, Neoptolemos J, Real FX.

    GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer.

    Gut . : .

    [doi:10.1136/gutjnl-2015-311256]

  • Villacampa A, Shamoon L, Valencia I, Morales C, Figueiras S, de la Cuesta F, Sánchez-Niño D, Díaz-Araya G, Sánchez-Pérez I, Lorenzo Ó, Sánchez-Ferrer CF, Peiró C.

    SARS-CoV-2 S Protein Reduces Cytoprotective Defenses and Promotes Human Endothelial Cell Senescence.

    AGING AND DISEASE . : .

    [doi:10.14336/AD.2024.0405]

  • Guerrero P, Albarrán V, González-Merino C, García de Quevedo C, Sotoca P, Chamorro J, Rosero DI, Barrill A, Alía V, Calvo JC, Moreno J, Pérez de Aguado P, Álvarez-Ballesteros P, San Román M, Serrano JJ, Soria A, Olmedo ME, Saavedra C, Cortés A, Gómez A, Lage Y, Ruiz Á, Ferreiro MR, Longo F, Guerra E, Martínez-Delfrade Í, Garrido P, Gajate P.

    Detrimental effect of an early exposure to antibiotics on the outcomes of immunotherapy in a multi-tumor cohort of patients.

    ONCOLOGIST . : .

    [doi:10.1093/oncolo/oyae284]

  • Biesma NC, Graus MUJE, Cirkel GA, Besselink MG, de Groot JWB, Koerkamp BG, Herbschleb KH, Los M, Verdonk RC, Wilmink JW, Cervantes A, Valle JW, Valkenburg-van Iersel LBJ, Froeling FEM, Molenaar IQ, Daamen LA, de Vos-Geelen J, van Santvoort HC.

    Perspectives of the medical oncologist regarding adjuvant chemotherapy for pancreatic cancer: An international expert survey and case vignette study.

    EJSO . 51(3): 109544-109544.

    [doi:10.1016/j.ejso.2024.109544]