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Biomarkers and Personalized Approach to Cancer Group (BioPAC)

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  • Urbanova M, Cihova M, Buocikova V, Slopovsky J, Dubovan P, Pindak D, Tomas M, García-Bermejo L, Rodríguez-Garrote M, Earl J, Kohl Y, Kataki A, Dusinska M, Sainz B Jr, Smolkova B, Gabelova A.

    Nanomedicine and epigenetics: New alliances to increase the odds in pancreatic cancer survival.

    BIOMEDICINE & PHARMACOTHERAPY . 165: 115179-115179. Number of citations: 1

    [doi:10.1016/j.biopha.2023.115179]

  • Herrero JM, Fabra D, Matesanz AI, Hernández C, Sánchez-Pérez I, Quiroga AG.

    Dithiobiureas Palladium(II) complexes' studies: From their synthesis to their biological action.

    JOURNAL OF INORGANIC BIOCHEMISTRY . 246: 112261-112261.

    [doi:10.1016/j.jinorgbio.2023.112261]

  • Vaz-Salgado MA, Villamayor M, Albarrán V, Alía V, Sotoca P, Chamorro J, Rosero D, Barrill AM, Martín M, Fernandez E, Gutierrez JA, Rojas-Medina LM, Ley L.

    Recurrent Glioblastoma: A Review of the Treatment Options.

    Cancers . 15(17): .

    [doi:10.3390/cancers15174279]

  • Banda Sánchez C, Cubo Mateo N, Saldaña L, Valdivieso A, Earl J, González Gómez I, Rodríguez-Lorenzo LM.

    Selection and Optimization of a Bioink Based on PANC-1- Plasma/Alginate/Methylcellulose for Pancreatic Tumour Modelling.

    POLYMERS . 15(15): .

    [doi:10.3390/polym15153196]

  • Bargiela-Iparraguirre J, Herrero JM, Pajuelo-Lozano N, Perez M, Perona R, Quiroga AG, Calés C, Sanchez-Perez I.

    Regulatory effects of miR-19a on MAD2 expression and tumorigenesis in gastric cancer.

    Genes & Diseases . 10(4): 1180-1182.

    [doi:10.1016/j.gendis.2023.02.025]

  • Díaz-Alejo JF, April-Monn S, Cihova M, Buocikova V, Villalón López J, Urbanova M, Lechuga CG, Tomas M, Dubovan P, Sánchez BL, Páez SC, Sanjuanbenito A, Lobo E, Romio de la Heras E, Guerra C, de la Pinta C, Barreto Melian E, Rodríguez Garrote M, Carrato A, Ruiz-Cañas L, Sainz B Jr, Torres A, Smolkova B, Earl J.

    Establishment of Pancreatic Cancer-Derived Tumor Organoids and Fibroblasts From Fresh Tissue

    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS . (195): . Number of citations: 1

    [doi:10.3791/65229]

  • Carrión-Marchante R, Pinto-Díez C, Klett-Mingo JI, Palacios E, Barragán-Usero M, Pérez-Morgado MI, Pascual-Mellado M, Alcalá S, Ruiz-Cañas L, Sainz B Jr, González VM, Martín ME.

    An Aptamer against MNK1 for Non-Small Cell Lung Cancer Treatment.

    Pharmaceutics . 15(4): .

    [doi:10.3390/pharmaceutics15041273]

  • Frank KJ, Mulero-Sánchez A, Berninger A, Ruiz-Cañas L, Bosma A, Görgülü K, Wu N, Diakopoulos KN, Kaya-Aksoy E, Ruess DA, Kabacaoglu D, Schmidt F, Kohlmann L, van Tellingen O, Thijssen B, van de Ven M, Proost N, Kossatz S, Weber WA, Sainz B Jr, Bernards R, Algül H, Lesina M, Mainardi S.

    Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical investigation for KRAS mutant pancreatic cancer.

    CELL REPORTS MEDICINE . 3(11): 100815-100815.

    [doi:10.1016/j.xcrm.2022.100815]

  • Cave DD, Buonaiuto S, Sainz B Jr, Fantuz M, Mangini M, Carrer A, Di Domenico A, Iavazzo TT, Andolfi G, Cortina C, Sevillano M, Heeschen C, Colonna V, Corona M, Cucciardi A, Di Guida M, Batlle E, De Luca A, Lonardo E.

    LAMC2 marks a tumor-initiating cell population with an aggressive signature in pancreatic cancer.

    Journal Of Experimental & Clinical Cancer Research . 41(1): 315-315. Number of citations: 1

    [doi:10.1186/s13046-022-02516-w]

  • Alonso-Nocelo M, Ruiz-Cañas L, Sancho P, Görgülü K, Alcalá S, Pedrero C, Vallespinos M, López-Gil JC, Ochando M, García-García E, David Trabulo SM, Martinelli P, Sánchez-Tomero P, Sánchez-Palomo C, Gonzalez-Santamaría P, Yuste L, Wörmann SM, Kabacaoglu D, Earl J, Martin A, Salvador F, Valle S, Martin-Hijano L, Carrato A, Erkan M, García-Bermejo L, Hermann PC, Algül H, Moreno-Bueno G, Heeschen C, Portillo F, Cano A, Sainz B Jr.

    Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma.

    Gut . 72(2): 345-359. Number of citations: 3

    [doi:10.1136/gutjnl-2021-325564]

  • Muñoz Velasco R, Jiménez Sánchez P, García García A, Blanco Martinez-Illescas R, Pastor Senovilla Á, Lozano Yagüe M, Trento A, García-Martin RM, Navarro D, Sainz B Jr, Rodríguez Peralto JL, Sánchez-Arévalo Lobo VJ.

    Targeting BPTF Sensitizes Pancreatic Ductal Adenocarcinoma to Chemotherapy by Repressing ABC-Transporters and Impairing Multidrug Resistance (MDR).

    Cancers . 14(6): .

    [doi:10.3390/cancers14061518]

  • Alors-Perez E, Blázquez-Encinas R, Alcalá S, Viyuela-García C, Pedraza-Arevalo S, Herrero-Aguayo V, Jiménez-Vacas JM, Mafficini A, Sánchez-Frías ME, Cano MT, Abollo-Jiménez F, Marín-Sanz JA, Cabezas-Sainz P, Lawlor RT, Luchini C, Sánchez L, Sánchez-Hidalgo JM, Ventura S, Martin-Hijano L, Gahete MD, Scarpa A, Arjona-Sánchez Á, Ibáñez-Costa A, Sainz B Jr, Luque RM, Castaño JP.

    Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug

    Journal Of Experimental & Clinical Cancer Research . 40(1): 382-382. Number of citations: 5

    [doi:10.1186/s13046-021-02153-9]

  • Walter K, Rodriguez-Aznar E, Ferreira MSV, Frappart PO, Dittrich T, Tiwary K, Meessen S, Lerma L, Daiss N, Schulte LA, Najafova Z, Arnold F, Usachov V, Azoitei N, Erkan M, Lechel A, Brümmendorf TH, Seufferlein T, Kleger A, Tabarés E, Günes C, Johnsen SA, Beier F, Sainz B Jr, Hermann PC.

    Telomerase and Pluripotency Factors Jointly Regulate Stemness in Pancreatic Cancer Stem Cells

    Cancers . 13(13): . Number of citations: 6

    [doi:10.3390/cancers13133145]

  • Ai, Jiaoyu, Wormann, Sonja M, Gorgulu, Kivanc, Vallespinos, Mireia, Zagorac, Sladjana, Alcala, Sonia, Wu, Nan, Kabacaoglu, Derya, Berninger, Alexandra, Navarro, Diego, Kaya-Aksoy, Ezgi, Ruess, Dietrich A, Ciecielski, Katrin J, Kowalska, Marlena, Demir, Ekin I, Ceyhan, Guralp O, Heid, Irina, Braren, Rickmer, Riemann, Marc, Schreiner, Sabrina, Hofmann, Samuel, Kutschke, Maria, Jastroch, Martin, Slotta-Huspenina, Julia, Muckenhuber, Alexander, Schlitter, Anna Melissa, Schmid, Roland M, Steiger, Katja, Diakopoulos, Kalliope N, Lesina, Marina, Sainz, Bruno Jr, Algul, Hana.

    BCL3 couples cancer stem cell enrichment with pancreatic cancer molecular subtypes.

    Gastroenterology . 161(1): 318. Number of citations: 4

    [doi:10.1053/j.gastro.2021.03.051]

  • Conde, Elisa, Earl, Julie, Crespo-Toro, Lorena, Blanco-Agudo, Carolina, Ramos-Munoz, Edurne, Rodriguez-Serrano, E. Macarena, Martinez avila, Jose Carlos, Salinas-Munoz, Laura, Serrano-Huertas, Silvia, Ferreiro, Reyes, Rodriguez-Garrote, Mercedes, Sainz B Jr, Massuti, Bartomeu, Alfonso, Pilar Garcia, Benavides, Manuel, Aranda, Enrique, Garcia-Bermejo, Maria Laura, Carrato, Alfredo.

    Biomarkers Associated with Regorafenib First-Line Treatment Benefits in Metastatic Colorectal Cancer Patients: REFRAME Molecular Study

    Cancers . 13(7): . Number of citations: 6

    [doi:10.3390/cancers13071710]

  • Earl, Julie, Barreto, Emma, Castillo, Maria E., Fuentes, Raquel, Rodriguez-Garrote, Mercedes, Ferreiro, Reyes, Reguera, Pablo, Munoz, Gloria, Garcia-Seisdedos, David, Lopez, Jorge Villalon, Sainz, Bruno, Malats, Nuria, Carrato, Alfredo.

    Somatic Mutation Profiling in the Liquid Biopsy and Clinical Analysis of Hereditary and Familial Pancreatic Cancer Cases Reveals KRAS Negativity and a Longer Overall Survival

    Cancers . 13(7): . Number of citations: 4

    [doi:10.3390/cancers13071612]

  • Gout, Johann, Perkhofer, Lukas, Morawe, Mareen, Arnold, Frank, Ihle, Michaela, Biber, Stephanie, Lange, Sebastian, Roger, Elodie, Kraus, Johann M., Stifter, Katja, Hahn, Stephan A., Zamperone, Andrea, Engleitner, Thomas, Muller M, Walter, Karolin, Rodriguez-Aznar, Eva, Sainz B Jr, Hermann, Patrick C., Hessmann, Elisabeth, Muller S, Azoitei, Ninel, Lechel, Andre, Liebau, Stefan, Wagner, Martin, Simeone, Diane M., Kestler, Hans A., Seufferlein, Thomas, Wiesmuller L, Rad, Roland, Frappart, Pierre-Olivier, Kleger, Alexander.

    Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer

    Gut . 70(4): 743-760. Number of citations: 39

    [doi:10.1136/gutjnl-2019-319970]

  • Courtois, Sarah, de Luxan-Delgado, Beatriz, Penin-Peyta, Laure, Royo-Garcia, Alba, Parejo-Alonso, Beatriz, Jagust, Petra, Alcala, Sonia, Rubiolo, Juan A., Sanchez, Laura, Sainz B Jr, Heeschen, Christopher, Sancho, Patricia.

    Inhibition of Mitochondrial Dynamics Preferentially Targets Pancreatic Cancer Cells with Enhanced Tumorigenic and Invasive Potential

    Cancers . 13(4): . Number of citations: 22

    [doi:10.3390/cancers13040698]