Biomarkers and Personalized Approach to Cancer Group (BioPAC)
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Only original articles, editorials, guidelines.
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Díaz-Alejo JF, April-Monn S, Cihova M, Buocikova V, Villalón López J, Urbanova M, Lechuga CG, Tomas M, Dubovan P, Sánchez BL, Páez SC, Sanjuanbenito A, Lobo E, Romio de la Heras E, Guerra C, de la Pinta C, Barreto Melian E, Rodríguez Garrote M, Carrato A, Ruiz-Cañas L, Sainz B Jr, Torres A, Smolkova B, Earl J.
Establishment of Pancreatic Cancer-Derived Tumor Organoids and Fibroblasts From Fresh Tissue
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS . (195): . Number of citations: 1
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Carrión-Marchante R, Pinto-Díez C, Klett-Mingo JI, Palacios E, Barragán-Usero M, Pérez-Morgado MI, Pascual-Mellado M, Alcalá S, Ruiz-Cañas L, Sainz B Jr, González VM, Martín ME.
An Aptamer against MNK1 for Non-Small Cell Lung Cancer Treatment.
Pharmaceutics . 15(4): .
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Frank KJ, Mulero-Sánchez A, Berninger A, Ruiz-Cañas L, Bosma A, Görgülü K, Wu N, Diakopoulos KN, Kaya-Aksoy E, Ruess DA, Kabacaoglu D, Schmidt F, Kohlmann L, van Tellingen O, Thijssen B, van de Ven M, Proost N, Kossatz S, Weber WA, Sainz B Jr, Bernards R, Algül H, Lesina M, Mainardi S.
Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical investigation for KRAS mutant pancreatic cancer.
CELL REPORTS MEDICINE . 3(11): 100815-100815.
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Cave DD, Buonaiuto S, Sainz B Jr, Fantuz M, Mangini M, Carrer A, Di Domenico A, Iavazzo TT, Andolfi G, Cortina C, Sevillano M, Heeschen C, Colonna V, Corona M, Cucciardi A, Di Guida M, Batlle E, De Luca A, Lonardo E.
LAMC2 marks a tumor-initiating cell population with an aggressive signature in pancreatic cancer.
Journal Of Experimental & Clinical Cancer Research . 41(1): 315-315. Number of citations: 1
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Alonso-Nocelo M, Ruiz-Cañas L, Sancho P, Görgülü K, Alcalá S, Pedrero C, Vallespinos M, López-Gil JC, Ochando M, García-García E, David Trabulo SM, Martinelli P, Sánchez-Tomero P, Sánchez-Palomo C, Gonzalez-Santamaría P, Yuste L, Wörmann SM, Kabacaoglu D, Earl J, Martin A, Salvador F, Valle S, Martin-Hijano L, Carrato A, Erkan M, García-Bermejo L, Hermann PC, Algül H, Moreno-Bueno G, Heeschen C, Portillo F, Cano A, Sainz B Jr.
Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma.
Gut . 72(2): 345-359. Number of citations: 3
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Muñoz Velasco R, Jiménez Sánchez P, García García A, Blanco Martinez-Illescas R, Pastor Senovilla Á, Lozano Yagüe M, Trento A, García-Martin RM, Navarro D, Sainz B Jr, Rodríguez Peralto JL, Sánchez-Arévalo Lobo VJ.
Targeting BPTF Sensitizes Pancreatic Ductal Adenocarcinoma to Chemotherapy by Repressing ABC-Transporters and Impairing Multidrug Resistance (MDR).
Cancers . 14(6): .
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Alors-Perez E, Blázquez-Encinas R, Alcalá S, Viyuela-García C, Pedraza-Arevalo S, Herrero-Aguayo V, Jiménez-Vacas JM, Mafficini A, Sánchez-Frías ME, Cano MT, Abollo-Jiménez F, Marín-Sanz JA, Cabezas-Sainz P, Lawlor RT, Luchini C, Sánchez L, Sánchez-Hidalgo JM, Ventura S, Martin-Hijano L, Gahete MD, Scarpa A, Arjona-Sánchez Á, Ibáñez-Costa A, Sainz B Jr, Luque RM, Castaño JP.
Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug
Journal Of Experimental & Clinical Cancer Research . 40(1): 382-382. Number of citations: 5
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Walter K, Rodriguez-Aznar E, Ferreira MSV, Frappart PO, Dittrich T, Tiwary K, Meessen S, Lerma L, Daiss N, Schulte LA, Najafova Z, Arnold F, Usachov V, Azoitei N, Erkan M, Lechel A, Brümmendorf TH, Seufferlein T, Kleger A, Tabarés E, Günes C, Johnsen SA, Beier F, Sainz B Jr, Hermann PC.
Telomerase and Pluripotency Factors Jointly Regulate Stemness in Pancreatic Cancer Stem Cells
Cancers . 13(13): . Number of citations: 6
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Ai, Jiaoyu, Wormann, Sonja M, Gorgulu, Kivanc, Vallespinos, Mireia, Zagorac, Sladjana, Alcala, Sonia, Wu, Nan, Kabacaoglu, Derya, Berninger, Alexandra, Navarro, Diego, Kaya-Aksoy, Ezgi, Ruess, Dietrich A, Ciecielski, Katrin J, Kowalska, Marlena, Demir, Ekin I, Ceyhan, Guralp O, Heid, Irina, Braren, Rickmer, Riemann, Marc, Schreiner, Sabrina, Hofmann, Samuel, Kutschke, Maria, Jastroch, Martin, Slotta-Huspenina, Julia, Muckenhuber, Alexander, Schlitter, Anna Melissa, Schmid, Roland M, Steiger, Katja, Diakopoulos, Kalliope N, Lesina, Marina, Sainz, Bruno Jr, Algul, Hana.
BCL3 couples cancer stem cell enrichment with pancreatic cancer molecular subtypes.
Gastroenterology . 161(1): 318. Number of citations: 4
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Conde, Elisa, Earl, Julie, Crespo-Toro, Lorena, Blanco-Agudo, Carolina, Ramos-Munoz, Edurne, Rodriguez-Serrano, E. Macarena, Martinez avila, Jose Carlos, Salinas-Munoz, Laura, Serrano-Huertas, Silvia, Ferreiro, Reyes, Rodriguez-Garrote, Mercedes, Sainz B Jr, Massuti, Bartomeu, Alfonso, Pilar Garcia, Benavides, Manuel, Aranda, Enrique, Garcia-Bermejo, Maria Laura, Carrato, Alfredo.
Biomarkers Associated with Regorafenib First-Line Treatment Benefits in Metastatic Colorectal Cancer Patients: REFRAME Molecular Study
Cancers . 13(7): . Number of citations: 6
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Earl, Julie, Barreto, Emma, Castillo, Maria E., Fuentes, Raquel, Rodriguez-Garrote, Mercedes, Ferreiro, Reyes, Reguera, Pablo, Munoz, Gloria, Garcia-Seisdedos, David, Lopez, Jorge Villalon, Sainz, Bruno, Malats, Nuria, Carrato, Alfredo.
Somatic Mutation Profiling in the Liquid Biopsy and Clinical Analysis of Hereditary and Familial Pancreatic Cancer Cases Reveals KRAS Negativity and a Longer Overall Survival
Cancers . 13(7): . Number of citations: 4
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Gout, Johann, Perkhofer, Lukas, Morawe, Mareen, Arnold, Frank, Ihle, Michaela, Biber, Stephanie, Lange, Sebastian, Roger, Elodie, Kraus, Johann M., Stifter, Katja, Hahn, Stephan A., Zamperone, Andrea, Engleitner, Thomas, Muller M, Walter, Karolin, Rodriguez-Aznar, Eva, Sainz B Jr, Hermann, Patrick C., Hessmann, Elisabeth, Muller S, Azoitei, Ninel, Lechel, Andre, Liebau, Stefan, Wagner, Martin, Simeone, Diane M., Kestler, Hans A., Seufferlein, Thomas, Wiesmuller L, Rad, Roland, Frappart, Pierre-Olivier, Kleger, Alexander.
Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer
Gut . 70(4): 743-760. Number of citations: 39
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Delle Cave, Donatella, Rizzo, Riccardo, Sainz B Jr, Gigli, Giuseppe, del Mercato, Loretta L., Lonardo, Enza.
The Revolutionary Roads to Study Cell-Cell Interactions in 3D In Vitro Pancreatic Cancer Models
Cancers . 13(4): . Number of citations: 16
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Courtois, Sarah, de Luxan-Delgado, Beatriz, Penin-Peyta, Laure, Royo-Garcia, Alba, Parejo-Alonso, Beatriz, Jagust, Petra, Alcala, Sonia, Rubiolo, Juan A., Sanchez, Laura, Sainz B Jr, Heeschen, Christopher, Sancho, Patricia.
Inhibition of Mitochondrial Dynamics Preferentially Targets Pancreatic Cancer Cells with Enhanced Tumorigenic and Invasive Potential
Cancers . 13(4): . Number of citations: 22
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López-Gil JC, Martin-Hijano, Laura, Hermann, Patrick C., Sainz B Jr.
The CXCL12 Crossroads in Cancer Stem Cells and Their Niche
Cancers . 13(3): . Number of citations: 23
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Alcala, Sonia, Mayoral-Varo, Victor, Ruiz-Canas, Laura, Lopez-Gil, Juan Carlos, Heeschen, Christopher, Martin-Perez, Jorge, Sainz B Jr.
Targeting SRC Kinase Signaling in Pancreatic Cancer Stem Cells (vol 21, 7437, 2020)
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES . 21(23): .
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Valle, Sandra, Alcala, Sonia, Martin-Hijano, Laura, Cabezas-Sainz, Pablo, Navarro, Diego, Munoz ER, Yuste, Lourdes, Tiwary, Kanishka, Walter, Karolin, Ruiz-Canas, Laura, Alonso-Nocelo, Marta, Rubiolo, Juan A., Gonzalez-Arnay, Emilio, Heeschen, Christopher, Garcia-Bermejo, Laura, Hermann, Patrick C., Sanchez, Laura, Sancho, Patricia, Fernandez-Moreno MA, Sainz B Jr.
Exploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells
NATURE COMMUNICATIONS . 11(1): 5265-5265. Number of citations: 55
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Alcala, Sonia, Mayoral-Varo, Victor, Ruiz-Canas, Laura, Lopez-Gil, Juan Carlos, Heeschen, Christopher, Martin-Perez, Jorge, Sainz B Jr.
Targeting SRC Kinase Signaling in Pancreatic Cancer Stem Cells
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES . 21(20): . Number of citations: 6