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Enfermedades Neurodegenerativas: desarrollo de terapias

Buscador de publicaciones

Sólo se han incluido artículos originales, editoriales y revisiones.

  • Gomez-Almeria M, Martinez-Gonzalez L, Matos AT, Rodriguez-Cueto C, Vaz AR, Martín-Baquero R, Pérez de la Lastra C, Infantes R, Fernández-Ruiz J, Palomo V, Gil C, Brites D, Martinez A, de Lago E.

    Assessment of the therapeutic effect of IGS2.7, a CK1d protein kinase inhibitor, in combination with riluzole for the treatment of ALS-associated TDP-43 proteinopathy.

    Neuropharmacology . 285: 110804-110804.

    [doi:10.1016/j.neuropharm.2025.110804]

  • Viqueira L, Navarro E, Negredo P, Bernal JA, Rodríguez-Franco MI, Tortosa E, López MG.

    Long-term NRF2-driven microglial repopulation mitigates microgliosis, neuronal loss and cognitive deficits in tauopathy.

    BRAIN BEHAVIOR AND IMMUNITY . 133: 106253-106253.

    [doi:10.1016/j.bbi.2026.106253]

  • Mir HD, Giorgini G, Santos-García I, Dumais E, Rodríguez-Cueto C, de Lago E, Silvestri C, Flamand N, Fernández-Ruiz J, Di Marzo V.

    Defining the Intestinal eCBome and Oxylipin Signaling Systems in a TDP-43 Mouse Model of Frontotemporal Dementia.

    FASEB JOURNAL . 40(2): .

    [doi:10.1096/fj.202502312RR]

  • Fernández-Ruiz J, Sagredo O, Gómez-Ruiz M, de Lago E.

    Ageing, Neurodegeneration and the Endocannabinoid System.

    Current Topics in Behavioral Neurosciences . 76: 209-248.

    [doi:10.1007/7854_2025_597]

  • Gómez-Almería M, Gonzalo-Consuegra C, Rodríguez-Cueto C, Cabañas-Cotillas M, Jiménez-Amor A, Machín-Díaz I, Wittwer MB, Dzygiel P, Clemente D, Grether U, Fernández-Ruiz J, de Lago E.

    Relevance of a peripheral site of action outside the brain-blood barrier for the beneficial effects of CB2 receptor activation in experimental ALS in male mice

    Cell Communication and Signaling . 23(1): 427-427.

    [doi:10.1186/s12964-025-02418-2]

  • Íñigo-Catalina L, Ortiz-Cabello M, Navarro E, Esteras N, Rancan L, Paredes SD.

    Melatonin-Mediated Nrf2 Activation as a Potential Therapeutic Strategy in Mutation-Driven Neurodegenerative Diseases

    Antioxidants . 14(10): . Nº de citas: 2

    [doi:10.3390/antiox14101190]

  • Rodriguez-Carreiro, Santiago, Gomez-Canas, Maria, Lubrini, Francesca, Gonzalo-Consuegra, Claudia, Winkler, Matthias, Caprioglio, Diego, Appendino, Giovanni, Garcia, Concepcion, Morales, Paula, Jagerovic, Nadine, Fischerd, Joerg T., Fiebich, Bernd L., Goetz, Marcus R., Munoz, Eduardo, Fernandez-Ruiz, Javier.

    Investigation in the CB1 and CB2 receptor binding profile and intrinsic activity of (-) and (+)-enantiomers of some naturally occurring phytocannabinoids or synthetic derivatives

    European Journal of Medicinal Chemistry Reports . 14: . Nº de citas: 2

    [doi:10.1016/j.ejmcr.2025.100262]

  • García-Toscano L, Rodríguez-Cueto C, Furiano A, Hind W, de Lago E, Fernández-Ruiz J.

    Preclinical evaluation of cannabidiolic acid as a neuroprotective agent in TDP-43 transgenic mice, an experimental model of amyotrophic lateral sclerosis.

    BIOMEDICINE & PHARMACOTHERAPY . 189: 118288-118288. Nº de citas: 2

    [doi:10.1016/j.biopha.2025.118288]

  • Fusaro L, Bangari DS, Pasterkamp RJ, Fernández-Ruiz J, Youssef SA, Sharma AK.

    Neurodegenerative Diseases: Pathogenesis and Preclinical Models for Translational Drug Discovery.

    TOXICOL PATHOL . 53(4): 364-371.

    [doi:10.1177/01926233251339105]

  • Seo H, Cuddleston WH, Fu T, Navarro E, Parks M, Allan A, Efthymiou AG, Breen MS, Xiao X, Raj T, Humphrey J.

    Cytosine-to-uracil RNA editing is upregulated by pro-inflammatory stimulation of myeloid cells.

    Biorxiv : The Preprint Server For Biology . : .

    [doi:10.1101/2025.03.14.643382]

  • Alonso C, García-Culebras A, Satta V, Hernández-Fisac I, Sierra Á, Guimaré JA, Lizasoain I, Fernández-Ruiz J, Sagredo O.

    Investigation in blood-brain barrier integrity and susceptibility to immune cell penetration in a mouse model of Dravet syndrome

    Brain Behavior & Immunity-Health . 44: 100955-100955. Nº de citas: 3

    [doi:10.1016/j.bbih.2025.100955]

  • Humphrey J, Brophy E, Kosoy R, Zeng B, Coccia E, Mattei D, Ravi A, Naito T, Efthymiou AG, Navarro E, De Sanctis C, Flores-Almazan V, Muller BZ, Snijders GJLJ, Allan A, Münch A, Kitata RB, Kleopoulos SP, Argyriou S, Malakates P, Psychogyiou K, Shao Z, Francoeur N, Tsai CF, Gritsenko MA, Monroe ME, Paurus VL, Weitz KK, Shi T, Sebra R, Liu T, de Witte LD, Goate AM, Bennett DA, Haroutunian V, Hoffman GE, Fullard JF, Roussos P, Raj T.

    Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing

    NATURE GENETICS . 57(3): 604-615. Nº de citas: 6

    [doi:10.1038/s41588-025-02099-0]

  • Navarro E, Montesinos J.

    Mitochondria-Associated Endoplasmic Reticulum Membranes in Microglia: One Contact Site to Rule Them all.

    Contact (thousand Oaks (ventura County, Calif.)) . 8: .

    [doi:10.1177/25152564241312807]

  • Gómez-Cañas M, Rodríguez-Cueto C, Fernández-Ruiz J, de Lago E.

    Development of Novel Neuroprotective Agents Targeting GPCR Using in Vitro Assays.

    Methods in molecular biology (Clifton, N.J.) . 2899: 339-366.

    [doi:10.1007/978-1-0716-4386-0_22]

  • Navarro, Elisa, Esteras, Noemi.

    Multitarget Effects of Nrf2 Signalling in the Brain: Common and Specific Functions in Different Cell Types

    Antioxidants . 13(12): . Nº de citas: 21

    [doi:10.3390/antiox13121502]

  • Choya-Foces C, Navarro E, Ríos CL, López MG, Egea J, Hernansanz-Agustín P, Martínez-Ruiz A.

    The mitochondrial Na(+)/Ca(2+) exchanger NCLX is implied in the activation of hypoxia-inducible factors.

    Redox Biology . 77: 103364-103364. Nº de citas: 8

    [doi:10.1016/j.redox.2024.103364]

  • Burgaz S, Navarro E, Rodríguez-Carreiro S, Navarrete C, Garrido-Rodríguez M, Lastres-Becker I, Chocarro J, Lanciego JL, Muñoz E, Fernández-Ruiz J.

    Investigation in the cannabigerol derivative VCE-003.2 as a disease-modifying agent in a mouse model of experimental synucleinopathy.

    Behavioral and Brain Functions . 20(1): 28-28. Nº de citas: 1

    [doi:10.1186/s12993-024-00256-9]

  • Silva-Llanes I, Martín-Baquero R, Berrojo-Armisen A, Rodríguez-Cueto C, Fernández-Ruiz J, De Lago E, Lastres-Becker I.

    Beneficial Effect of Dimethyl Fumarate Drug Repositioning in a Mouse Model of TDP-43-Dependent Frontotemporal Dementia.

    Antioxidants . 13(9): . Nº de citas: 1

    [doi:10.3390/antiox13091072]