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Translational Haematology

Our Translational Hematology group was created with the aim of generating knowledge in the field of hematology and collaborating with other groups for the implementation of projects. Our activity is based on a broad portfolio of clinical trials, basic research projects and registry studies. The area of ​​knowledge in which we focus is the study of the immune system and its relationship with oncohematological diseases and their infectious complications, cell therapy, study of the adverse effects of drugs and optimization in obtaining and using blood components in Transfusion Therapy

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Only original articles, editorials, guidelines.

  • Sargas, Claudia, Ayala, Rosa, Larrayoz, Maria Jose, Chillon, Maria Carmen, Carrillo-Cruz, Estrella, Bilbao-Sieyro, Cristina, Prados de la Torre, Esther, Martinez-Cuadron, David, Rodriguez-Veiga, Rebeca, Boluda, Blanca, Gil, Cristina, Bernal, Teresa, Bergua, Juan Miguel, Algarra, Lorenzo, Tormo, Mar, Martinez-Sanchez, Pilar, Soria, Elena, Serrano, Josefina, Alonso-Dominguez, Juan Manuel, Garcia-Boyero, Raimundo, Amigo, Maria Luz, Herrera-Puente, Pilar, Sayas, Maria Jose, Lavilla-Rubira, Esperanza, Martinez-Lopez, Joaquin, Calasanz, Maria Jose, Garcia-Sanz, Ramon, Perez-Simon, Jose Antonio, Gomez-Casares, Maria Teresa, Sanchez-Garcia, Joaquin, Barragan, Eva, Montesinos, Pau, On Behalf Of Pethema Group.

    Molecular Landscape and Validation of New Genomic Classification in 2668 Adult AML Patients: Real Life Data from the PETHEMA Registry

    Cancers . 15(2): . Number of citations: 6

    [doi:10.3390/cancers15020438]

  • Pascual Izquierdo MC, Mingot-Castellano ME, Kerguelen Fuentes AE, García-Arroba Peinado J, Cid J, Jiménez M, Valcarcel D, Gomez-Segui I, de la Rubia J, Martin P, Goterris R, Hernández-Mateo LM, Tallón Ruiz I, Varea S, Fernández-Docampp M, García-Muñoz N, Vara M, Fernández Zarzoso M, García-Candel F, Paciello ML, García-García I, Zalba S, Campuzano Saavedra V, Garcia-Gala JMM, Vidan J, Moreno G, Lopez Lorenzo JL, González Arias E, Freiría C, Solé M, Ávila Idrovo LF, Hernández Castellet JC, Cruz N, Lavilla E, Pérez-Montaña A, Atucha JA, Moreno Beltrán ME, Romero Macías JR, Salinas Argente R, Del Rio-Garma J.

    Real-world effectiveness of caplacizumab vs standard of care in immune thrombotic thrombocytopenic purpura.

    Blood Advances . 6(24): 6219-6227. Number of citations: 9

    [doi:10.1182/bloodadvances.2022008028]

  • Nadarajah R, Ludman P, Appelman Y, Brugaletta S, Budaj A, Bueno H, Huber K, Kunadian V, Leonardi S, Lettino M, Milasinovic D, Gale CP.

    Cohort profile: the ESC EURObservational Research Programme Non-ST-segment elevation myocardial infraction (NSTEMI) Registry.

    EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES . 9(1): 8-15.

    [doi:10.1093/ehjqcco/qcac067]

  • Ayala R, Carreño-Tarragona G, Barragán E, Boluda B, Larráyoz MJ, Chillón MC, Carrillo-Cruz E, Bilbao C, Sánchez-García J, Bernal T, Martinez-Cuadron D, Gil C, Serrano J, Rodriguez-Medina C, Bergua J, Pérez-Simón JA, Calbacho M, Alonso-Domínguez JM, Labrador J, Tormo M, Amigo ML, Herrera-Puente P, Rapado I, Sargas C, Vazquez I, Calasanz MJ, Gomez-Casares T, García-Sanz R, Sanz MA, Martínez-López J, Montesinos P.

    Impact of FLT3-ITD Mutation Status and Its Ratio in a Cohort of 2901 Patients Undergoing Upfront Intensive Chemotherapy: A PETHEMA Registry Study

    Cancers . 14(23): . Number of citations: 4

    [doi:10.3390/cancers14235799]

  • Barbui T, Carobbio A, Ghirardi A, Iurlo A, Sobas MA, Elli EM, Rumi E, De Stefano V, Lunghi F, Marchetti M, Daffini R, Gasior Kabat M, Cuevas B, Fox ML, Andrade-Campos MM, Palandri F, Guglielmelli P, Benevolo G, Harrison C, Foncillas MA, Bonifacio M, Alvarez-Larran A, Kiladjian JJ, Bolaños Calderón E, Patriarca A, Quiroz Cervantes K, Griesshammer M, Garcia-Gutierrez V, Marin Sanchez A, Magro Mazo E, Carli G, Hernandez-Boluda JC, Osorio S, Carreno-Tarragona G, Sagues Serrano M, Kusec R, Navas Elorza B, Angona A, Xicoy Cirici B, Lopez Abadia E, Koschmieder S, Cattaneo D, Bucelli C, Cichocka E, de Nalecz AK, Cavalca F, Borsani O, Betti S, Bellini M, Curto-Garcia N, Rambaldi A, Vannucchi AM.

    Determinants of early triage for hospitalization in myeloproliferative neoplasm (MPN) patients with COVID-19

    AMERICAN JOURNAL OF HEMATOLOGY . 97(12): 470-473. Number of citations: 3

    [doi:10.1002/ajh.26732]

  • Villar S, Ariceta B, Agirre X, Urribarri AD, Ayala R, Martínez-Cuadrón D, Bergua JM, Vives S, Algarra L, Tormo M, Martínez P, Serrano J, Simoes C, Herrera P, Calasanz MJ, Alfonso-Piérola A, Paiva B, Martínez-López J, San Miguel JF, Prósper F, Montesinos P.

    The transcriptomic landscape of elderly acute myeloid leukemia identifies B7H3 and BANP as a favorable signature in high-risk patients

    Frontiers in Oncology . 12: 1054458-1054458.

    [doi:10.3389/fonc.2022.1054458]

  • García-Abellás P, Ferrer Gómez A, Bueno Sacristán D, Piris Villaespesa M, Talavera Yagüe M, Reguero Callejas ME, García-Cosío M.

    Lymphoplasmacytic lymphoma and marginal zone lymphoma involving bone marrow: A diagnostic dilemma. Useful clinicopathological features to accurate the diagnosis.

    Ejhaem . 3(4): 1181-1187.

    [doi:10.1002/jha2.573]

  • Torres M, Corona M, Rodríguez-Mora S, Casado-Fernández G, Zurdo-Castronuño A, Mateos E, Ramos-Martín F, Sánchez-Menéndez C, Murciano-Antón MA, García-Pérez J, Alcamí J, Pérez-Olmeda M, Coiras M, López-Jiménez J, García-Gutiérrez V, On Behalf Of The Multidisciplinary Group Of Study Of Covid-Mgs-Covid.

    Strong Humoral but Not Cellular Immune Responses against SARS-CoV-2 in Individuals with Oncohematological Disease Who Were Treated with Rituximab before Receiving a Vaccine Booster

    Cancers . 14(22): .

    [doi:10.3390/cancers14225537]

  • Ortuzar A, Fox ML, Vera JA, Lorenzo Vizcaya Á, Marín Sánchez A, Llopis Calatayud I, Carbonell S, Álvarez-Larrán A, Mata Serna R, Marco Buades JE, Quiroz Cervantes K, Martínez Hellín Á, Blum Domínguez A, Caballero Navarro G, Cáceres Sansaloni A, Guerrero Fernández L, Muñoz Linares C, Gasior Kabat M, Pérez López R, Fernández Rodríguez Á, Martínez Bilbao C, Cobo Rodríguez MT, Díaz Á, Durán MA, Santaliestra Tomas M, García-Gutierrez V, Magro Mazo E, Hernández-Boluda JC, Segura A, Raya JM, Navas Elorza B, Osorio S.

    Philadelphia-negative chronic myeloproliferative neoplasm follow-up: when the phone rings. Changes during the COVID-19 pandemic and patient satisfaction. Experience in 30 health centers in Spain.

    ANNALS OF HEMATOLOGY . 102(2): 447-456.

    [doi:10.1007/s00277-022-05044-x]

  • Rey-Búa B, Cabrero M, Bento L, Montoro J, Bastos-Oreiro M, Parody R, Yañez L, Lopez-Godino O, Zanabili J, Herrera P, Gutierrez G, Perez A, Piñana JL, Novelli S, Cortés M, Sureda AM, Caballero D, García-Sancho AM.

    Allogeneic Hematopoietic Stem Cell Transplantation in Transformed Follicular Lymphoma (tFL): Results of a Retrospective Multicenter Study from GELTAMO/GETH-TC Spanish Groups

    Cancers . 14(22): .

    [doi:10.3390/cancers14225670]

  • Rosa-Rosa JM, Cuenca I, Medina A, Vázquez I, Sánchez-delaCruz A, Buenache N, Sánchez R, Jiménez C, Rosiñol L, Gutiérrez NC, Ruiz-Heredia Y, Barrio S, Oriol A, Martin-Ramos ML, Blanchard MJ, Ayala R, Ríos-Tamayo R, Sureda A, Hernández MT, de la Rubia J, Alkorta-Aranburu G, Agirre X, Bladé J, Mateos MV, Lahuerta JJ, San-Miguel JF, Calasanz MJ, Garcia-Sanz R, Martínez-Lopez J.

    NGS-Based Molecular Karyotyping of Multiple Myeloma: Results from the GEM12 Clinical Trial

    Cancers . 14(20): . Number of citations: 1

    [doi:10.3390/cancers14205169]

  • Mateos MV, Hernández MT, Salvador C, Rubia J, de Arriba F, López-Corral L, Rosiñol L, Paiva B, Palomera L, Bargay J, Oriol A, Prosper F, López J, Arguiñano JM, Bladé J, Lahuerta JJ, San-Miguel J.

    Original Research Lenalidomide-dexamethasone versus observation in high-risk smoldering myeloma after 12 years of median follow-up time: A randomized, open-label study*

    EUROPEAN JOURNAL OF CANCER . 174: 243-250. Number of citations: 6

    [doi:10.1016/j.ejca.2022.07.030]

  • Triguero A, Pedraza A, Pérez-Encinas M, Mata-Vázquez MI, Vélez P, Fox L, Gómez-Calafat M, García-Delgado R, Gasior M, Ferrer-Marín F, García-Gutiérrez V, Angona A, Gómez-Casares MT, Cuevas B, Martínez C, Pérez R, Raya JM, Guerrero L, Murillo I, Bellosillo B, Hernández-Boluda JC, Sanz C, Álvarez-Larrán A.

    Low-risk polycythemia vera treated with phlebotomies: clinical characteristics, hematologic control and complications in 453 patients from the Spanish Registry of Polycythemia Vera

    ANNALS OF HEMATOLOGY . 101(10): 2231-2239. Number of citations: 3

    [doi:10.1007/s00277-022-04963-z]

  • Luna A, Pérez-Lamas L, Boque C, Giraldo P, Xicoy B, Ruiz Nuño C, Vega MM, Alvarez-Larrán A, Salamanca A, García-Noblejas A, Vall-Llovera F, Villalon L, De Las Heras N, Ramila E, Pérez-Encinas M, Cuevas B, Perez-Lopez R, Sanchez-Guijo F, Jiménez-Velasco A, Lakhwani S, Casado LF, Rosell A, Escola A, Fernández MJ, Garcia-Hernandez C, Cervero C, Mora E, Sagüés M, Suarez-Varela S, Vélez P, Carrascosa Mastell P, Bitaube RF, Serrano L, Cortes M, Vera Goñi JA, Steegmann JL, de Soria VGG, Alonso-Dominguez JM, Araujo MC, Coll AP, Hernandez-Boluda JC, García-Gutiérrez V.

    Real-life analysis on safety and efficacy of asciminib for ponatinib pretreated patients with chronic myeloid leukemia

    ANNALS OF HEMATOLOGY . 101(10): 2263-2270. Number of citations: 6

    [doi:10.1007/s00277-022-04932-6]

  • Valle-Arroyo J, Páez-Vega A, Fernández-Moreno R, López-Jiménez J, Luna A, Duarte R, Serrano-Martínez F, Villar S, Fernández-Alonso M, Reina G, González-Rico C, Fariñas MC, Rojas R, Herrera C, Martín C, García-Torres E, Torre-Cisneros J, Cantisán S.

    Humoral/Cellular Immune Discordance in Stem Cell Donors: Impact on Cytomegalovirus-Specific Immune Reconstitution after Related Hematopoietic Transplantation

    Transplantation And Cellular Therapy . 28(10): .

    [doi:10.1016/j.jtct.2022.07.005]

  • Ruz-Caracuel I, Pian-Arias H, Corral Í, Carretero-Barrio I, Bueno-Sacristán D, Pérez-Mies B, García-Cosío M, Caniego-Casas T, Pizarro D, García-Narros MI, Piris-Villaespesa M, Pestaña D, de Pablo R, Galán JC, Masjuan J, Palacios J.

    Neuropathological findings in fatal COVID-19 and their associated neurological clinical manifestations

    Pathology . 54(6): 738-745. Number of citations: 7

    [doi:10.1016/j.pathol.2022.03.006]

  • Battipaglia G, Labopin M, Blaise D, Diez-Martin JL, Bazarbachi A, Vitek A, Chevallier P, Castagna L, Grillo G, Daguindau E, López-Jiménez J, Koc Y, Ruggeri A, Nagler A, Mohty M.

    Impact of the Addition of Antithymocyte Globulin to Post- Transplantation Cyclophosphamide in Haploidentical Transplantation with Peripheral Blood Compared to Post-Transplantation Cyclophosphamide Alone in Acute Myelogenous Leukemia: A Retrospective Study on Behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

    Transplantation And Cellular Therapy . 28(9): . Number of citations: 5

    [doi:10.1016/j.jtct.2022.06.006]

  • Tamariz-Amador LE, Rodríguez-Otero P, Jiménez-Ubieto A, Rosiñol L, Oriol A, Ríos R, Sureda A, Blanchard MJ, Hernández MT, Cabañas Perianes V, Jarque I, Bargay J, Gironella M, De Arriba F, Palomera L, Gonzalez-Montes Y, Martí JM, Krsnik I, Arguiñano JM, González ME, Casado LF, González-Rodriguez AP, López-Anglada L, Puig N, Cedena MT, Paiva B, Mateos MV, San-Miguel J, Lahuerta JJ, Bladé J, Trocóniz IF.

    Prognostic Value of Serum Paraprotein Response Kinetics in Patients With Newly Diagnosed Multiple Myeloma

    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA . 22(9): 844-852.

    [doi:10.1016/j.clml.2022.04.024]