Translational Haematology

Our Translational Hematology group was created with the aim of generating knowledge in the field of hematology and collaborating with other groups for the implementation of projects. Our activity is based on a broad portfolio of clinical trials, basic research projects and registry studies. The area of ​​knowledge in which we focus is the study of the immune system and its relationship with oncohematological diseases and their infectious complications, cell therapy, study of the adverse effects of drugs and optimization in obtaining and using blood components in Transfusion Therapy

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Only original articles, editorials, guidelines.

  • Garcia-Donas J, Martínez-Urbistondo D, Velázquez Kennedy K, Villares P, Barquin A, Dominguez A, Rodriguez-Moreno JF, Caro E, Suarez Del Villar R, Nistal-Villan E, Yagüe M, Ortiz M, Barba M, Ruiz-Llorente S, Quiralte M, Zanin M, Rodríguez C, Navarro P, Berraondo P, Madurga R.

    Randomized phase II clinical trial of ruxolitinib plus simvastatin in COVID19 clinical outcome and cytokine evolution

    Frontiers in immunology . 14: 1156603-1156603. Number of citations: 1

    [doi:10.3389/fimmu.2023.1156603]

  • Crees ZD, Rettig MP, Jayasinghe RG, Stockerl-Goldstein K, Larson SM, Arpad I, Milone GA, Martino M, Stiff P, Sborov D, Pereira D, Micallef I, Moreno-Jiménez G, Mikala G, Coronel MLP, Holtick U, Hiemenz J, Qazilbash MH, Hardy N, Latif T, García-Cadenas I, Vainstein-Haras A, Sorani E, Gliko-Kabir I, Goldstein I, Ickowicz D, Shemesh-Darvish L, Kadosh S, Gao F, Schroeder MA, Vij R, DiPersio JF.

    Motixafortide and G-CSF to mobilize hematopoietic stem cells for autologous transplantation in multiple myeloma: a randomized phase 3 trial.

    NATURE MEDICINE . 29(4): 869-879.

    [doi:10.1038/s41591-023-02273-z]

  • Rodríguez-Mora S, Pérez-Lamas L, Sainero MS, Torres M, Sánchez-Menéndez C, Corona M, Mateos E, Casado-Fernández G, Alcamí J, García-Pérez J, Pérez-Olmeda M, Murciano-Antón MA, López-Jiménez J, García-Gutiérrez V, Coiras M.

    Persistent Immunity against SARS-CoV-2 in Individuals with Oncohematological Diseases Who Underwent Autologous or Allogeneic Stem Cell Transplantation after Vaccination

    Cancers . 15(8): .

    [doi:10.3390/cancers15082344]

  • Núñez-Torrón Stock C, Jiménez Chillón C, Martín Moro F, Marquet Palomanes J, Velázquez Kennedy K, Piris Villaespesa M, Roldán Santiago E, Rodríguez Martín E, Chinea Rodríguez A, García Gutiérrez V, Moreno Jiménez G, López Jiménez J, Herrera Puente P.

    Patients with secondary acute myeloid leukemia undergoing allogeneic stem-cell transplant have inferior outcomes than de novo acute myeloid leukemia regardless minimal residual disease level by flow cytometry.

    HEMATOLOGICAL ONCOLOGY . : .

    [doi:10.1002/hon.3160]

  • García-García I, Cid J, Moreno-Jiménez G, Tenorio Núñez M, Jiménez Martín A, Vallés Carboneras A, Velázquez-Kennedy K, Lozano M, López-Jiménez FJ.

    Prediction of blood volume to be processed to achieve a target number of CD34+ cells: Development, validation and implementation of a formula.

    VOX SANGUINIS . 118(4): 288-295.

    [doi:10.1111/vox.13410]

  • Velasco-Rodríguez D, Martínez-Alfonzo I, Velasco-Valdazo AE, Revilla N, Mahíllo-Fernández I, Askari E, Castro-Quismondo N, Laso RV, Domingo-González A, Serrano-López J, Prieto E, Rosado B, Blanchard MJ, Martín-Herrero S, García-Raso A, Bueno MÁ, de la Plaza R, Peñaherrera M, López IG, López-Jiménez J, Martínez-López J, Llamas-Sillero P.

    Enhanced thrombin generation detected with ST-Genesia analyzer in patients with newly diagnosed multiple myeloma

    JOURNAL OF THROMBOSIS AND THROMBOLYSIS . 55(3): 464-473.

    [doi:10.1007/s11239-022-02765-8]

  • Hochhaus A, Réa D, Boquimpani C, Minami Y, Cortes JE, Hughes TP, Apperley JF, Lomaia E, Voloshin S, Turkina A, Kim DW, Abdo A, Fogliatto LM, le Coutre P, Sasaki K, Kim DDH, Saussele S, Annunziata M, Chaudhri N, Chee L, García-Gutiérrez V, Kapoor S, Allepuz A, Quenet S, Bédoucha V, Mauro MJ.

    Asciminib vs bosutinib in chronic-phase chronic myeloid leukemia previously treated with at least two tyrosine kinase inhibitors: longer-term follow-up of ASCEMBL

    Leukemia . 37(3): 617-626. Number of citations: 14

    [doi:10.1038/s41375-023-01829-9]

  • Rodenas-Quinonero, Isabel, Chen-Liang, Tzu, Martin-Santos, Taida, Salar, Antonio, Fernandez-Gonzalez, Marta, Celades, Carolina, Navarro, Jose-Tomas, Belen Martinez-Garcia, Ana, Andreu, Rafael, Balaguer, Aitana, Martin Garcia-Sancho, Alejandro, Baile, Monica, Lopez-Jimenez, Javier, Marquet-Palomanes, Juan, Isabel Teruel, Ana, Jose Terol, Maria, Benet, Carmen, Frutos, Laura, Luis Navarro, Jose, Una, Jon, Suarez, Marina, Cortes, Montserrat, Contreras, Jose, Ruiz, Cristina, Tamayo, Pilar, Mucientes, Jorge, Sopena-Novales, Pablo, Reguilon-Gallego, Laura, Javier Sanchez-Blanco, Jose, Perez-Ceballos, Elena, Jerez, Andres, Jose Ortuno, Francisco.

    Accuracy and prognostic impact of FDG PET/CT and biopsy in bone marrow assessment of follicular lymphoma at diagnosis: A Nation-Wide cohort study

    CANCER MEDICINE . 12(6): 6536-6546. Number of citations: 2

    [doi:10.1002/cam4.5424]

  • Alegre A, Benzo G, Alonso R, Martínez-López J, Jimenez-Ubieto A, Cuéllar C, Askari E, Prieto E, Aláez C, Aguado B, Velasco A, Krsnik I, Bocanegra A, Llorente L, Muñoz-Linares C, Morales A, Giménez E, Iglesias R, Martínez-Chamorro C, Alonso A, Jiménez-Montes C, Blanchard MJ.

    Real-World Outcomes of Belantamab Mafodotin for Relapsed/Refractory Multiple Myeloma (RRMM): Preliminary Results of a Spanish Expanded Access Program (EAP)

    Oncology and therapy . 11(1): 83-96. Number of citations: 5

    [doi:10.1007/s40487-022-00212-5]

  • Martínez-López J, De la Cruz J, Gil-Manso R, Alegre A, Ortiz J, Llamas P, Martínez Y, Hernández-Rivas JÁ, González-Gascón I, Benavente C, Estival Monteliu P, Jiménez-Yuste V, Canales M, Bastos M, Kwon M, Valenciano S, Callejas-Charavia M, López-Jiménez J, Herrera P, Duarte R, Núñez Martín-Buitrago L, Sanchez Godoy P, Jacome Yerovi C, Martínez-Barranco P, García Roa M, Escolano Escobar C, Matilla A, Rosado Sierra B, Aláez-Usón MC, Quiroz-Cervantes K, Martínez-Chamorro C, Pérez-Oteyza J, Martos-Martinez R, Herráez R, González-Santillana C, Del Campo JF, Alonso A, de la Fuente A, Pascual A, Bustelos-Rodriguez R, Sebrango A, Ruiz E, Marcheco-Pupo EA, Grande C, Cedillo Á, Lumbreras C, Arroyo Barea A, Casas-Rojo JM, Calbacho M, Diez-Martín JL, García-Suárez J.

    COVID-19 Severity and Survival over Time in Patients with Hematologic Malignancies: A Population-Based Registry Study.

    Cancers . 15(5): . Number of citations: 2

    [doi:10.3390/cancers15051497]

  • Bouza E, Martin M, Alés JE, Aragonés N, Barragán B, de la Cámara R, Del Pozo JL, García-Gutiérrez V, García-Sanz R, Gracia D, Guillem V, Jiménez-Yuste V, Martin-Delgado MC, Martínez J, López R, Rodríguez-Lescure A, Ruiz Galiana J, Sureda AM, Tejerina-Picado F, Trilla A, Zapatero A, Palomo E, San-Miguel J.

    Impact of the COVID-19 pandemic on the diagnosis and treatment of onco-hematologic patients: a discussion paper.

    REVISTA ESPANOLA DE QUIMIOTERAPIA . 36(1): 1-25.

    [doi:10.37201/req/087.2022]

  • Pérez-Lamas L, Luna A, Boque C, Xicoy B, Giraldo P, Pérez López R, Ruiz Nuño C, De Las Heras N, Mora Casterá E, López Marín J, Segura Díaz A, Gómez V, Vélez Tenza P, Sierra Pacho M, Vera Goñi JA, Moreno Vega M, Alvarez-Larrán A, Cortés M, Pérez Encinas M, Carrascosa Mastell P, Angona A, Rosell A, Lakhwani S, Colorado M, Ramila E, Cervero C, Cuevas B, Villalón Blanco L, de Paz R, Paz Coll A, Fernández MJ, Felipe Casado L, Alonso-Domínguez JM, Anguita Arance MM, Salamanca Cuenca A, Jiménez-Velasco A, Prendes SO, Santaliestra M, Lis Chulvi MJ, Hernández-Boluda JC, García-Gutiérrez V.

    Toxicity of Asciminib in Real Clinical Practice: Analysis of Side Effects and Cross-Toxicity with Tyrosine Kinase Inhibitors

    Cancers . 15(4): .

    [doi:10.3390/cancers15041045]

  • Fortún J, Mateos M, de la Pedrosa EG, Soriano C, Pestaña D, Palacios J, López J, Moreno S, Covid-Team.

    Invasive Pulmonary Aspergillosis in Patients with and without SARS-CoV-2 Infection

    JOURNAL OF FUNGI . 9(2): . Number of citations: 3

    [doi:10.3390/jof9020130]

  • Cruz D, Rodríguez-Romanos R, González-Bartulos M, García-Cadenas I, de la Cámara R, Heras I, Buño I, Santos N, Lloveras N, Velarde P, Tuset E, Martínez C, González M, Sanz GF, Ferrá C, Sampol A, Coll R, Pérez-Simón JA, López-Jiménez J, Jurado M, Gallardo D.

    LAG3 genotype of the donor and clinical outcome after allogeneic transplantation from HLA-identical sibling donors

    Frontiers in immunology . 14: 1066393-1066393.

    [doi:10.3389/fimmu.2023.1066393]

  • Casado-Fernández G, Corona M, Torres M, Saez AJ, Ramos-Martín F, Manzanares M, Vigón L, Mateos E, Pozo F, Casas I, García-Gutierrez V, Rodríguez-Mora S, Coiras M.

    Sustained Cytotoxic Response of Peripheral Blood Mononuclear Cells from Unvaccinated Individuals Admitted to the ICU Due to Critical COVID-19 Is Essential to Avoid a Fatal Outcome.

    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH . 20(3): .

    [doi:10.3390/ijerph20031947]

  • Piñana JL, Vazquez L, Calabuig M, López-Corral L, Martin-Martin G, Villalon L, Sanz-Linares G, Conesa-Garcia V, Sanchez-Salinas A, Gago B, Facal A, Risco-Gálvez I, Olave MT, Espigado I, Lopez-Jimenez J, Hernández-Rivas JÁ, Avendaño-Pita A, Arroyo I, Ferrer E, García-Cadenas I, González-Santillana C, Roldán-Pérez A, Ferrer B, Guerreiro M, Suarez-Lledó M, Camara A, Campos-Beltrán D, Navarro D, Cedillo Á, Sureda A, Solano C, Martino R.

    One-year breakthrough SARS-CoV-2 infection and correlates of protection in fully vaccinated hematological patients

    BLOOD CANCER JOURNAL . 13(1): 8-8. Number of citations: 9

    [doi:10.1038/s41408-022-00778-3]

  • Harrison C, Yacoub A, Scott B, Mead A, Gerds AT, Kiladjian JJ, Mesa R, Egyed M, Scheid C, Gutierrez VG, O'Sullivan J, Buckley S, Kanellopoulos K, Mascarenhas J.

    Long-term treatment with pacritinib on a compassionate use basis in patients with advanced myelofibrosis.

    Haematologica . : .

    [doi:10.3324/haematol.2022.282089]

  • Meijón Ortigueira MDM, Álvarez-Román MT, De La Corte Rodríguez H, Butta Coll N, Jiménez-Yuste V.

    Long-term impact of primary prophylaxis on joint status in patients with severe hemophilia A

    Research And Practice In Thrombosis And Haemostasis . 7(1): 100005-100005. Number of citations: 2

    [doi:10.1016/j.rpth.2022.100005]