Milestones

1. Development of biomarkers and innovative therapies in gastrointestinal tumors, including: a diagnostic kit for pancreatic cancer (AMADIX); response biomarkers in drug repositioning; multimodal and radiomic prognostic biomarkers in colorectal cancer (miRAmut-Quibim); European positioning in the diagnosis and identification of at-risk populations using reliable and standardized AI; and the advancement of CAR-T NK cell immunotherapies to overcome immunoevasion in colorectal cancer (IRYCIS 2030 MISSION).
2. Development of biomarkers for personalized medicine in the cardiorenal axis and clear cell renal cell carcinoma, through the identification of diagnostic, prognostic, and predictive molecular signatures (non-coding RNAs) (ISCIII, CAM, and RETICs projects); talent development (doctoral thesis); consolidation as a national and European reference group in radiobiology (ESTRO); and the implementation of spatial transcriptomics in a competitive European project (CANSERV). and the active integration of patients into an ISCIII PI project.
3. Consolidation as a leading European group in multi-omics and multimodal biomarkers aimed at generating reliable AI tools with clinical applicability, through national and European projects (EATRIS Plus, EATRIS Connect), with leadership in the development of digital platforms such as MultiomicToolBox and the Digital Hub, and the application of reliable AI assessment methodologies (z-inspection) in different biomedical contexts.
4. Consolidation as a leading group in drug repositioning and orphan drug designation, through European initiatives and projects such as REMEDi4ALL, in collaboration with policymakers (European Commission), regulatory agencies (EMA), and patient organizations (PEOF, EURORDIS, POP), promoting the reduction of animal model use (Humane World for Animals) in oncology and rare renal and vascular diseases.
5. Scientific direction of the Spanish node of the European Translational Medicine Infrastructure (EATRIS), with European leadership and positioning of a node made up of 35 institutions, and coordination of national and European strategic initiatives in citizen and patient participation, climate change and health, and digital transformation of health systems.