Milestones

1. miRNA-7 controls cholesterol biosynthesis through posttranscriptional regulation of DHCR24 expression (Fernández-de Frutos et al. "MiR-7 controls cholesterol biosynthesis through posttranscriptional regulation of DHCR24 expression" Biochim Biophys Acta Gene Regul Mech. 2023 Jun;1866(2):194938. DOI: 10.1016/j.bbagrm.2023.194938. PMID: 37086967)
2. Functional characterization of the apolipoprotein B p.(Lys3344Glu) variant has revealed that it is pathogenic, whereas the p.(Ser3801Thr) variant, so far of uncertain significance, is benign (Rodríguez-Jiménez et al. Identification and Functional Analysis of APOB Variants in a Cohort of Hypercholesterolemic Patients. Int J Mol Sci. 2023 Apr 21;24(8):7635. DOI: 10.3390/ijms24087635. PMID: 37108800)
3. Dihydroceramide concentrations correlate with the progression of metabolic dysfunction associated with fatty liver disease in patients and animal models (Babiy et al. Dihydrosphingolipids are associated with steatosis and increased fibrosis damage in non-alcoholic fatty liver disease. Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Jul;1868(7):159318. DOI: 10.1016/j.bbalip.2023.159318. PMID: 37059386)
4. Lymphocyte proliferation and cytokine secretion assays allowed the identification of drugs responsible for skin lesions during SARS-CoV-2 infection (Fernández-Lozano et al. Value of the Lymphocyte Transformation Test for the Diagnosis of Drug-Induced Hypersensitivity Reactions in Hospitalized Patients with Severe COVID-19. Int J Mol Sci. 2023 Jul 17;24(14):11543. DOI: 10.3390/ijms241411543. PMID: 37511302)
5. Obesity induces changes in lipid homeostasis in the mouse testis that affect the expression of HSL, lipid receptors/transporters (SR-BI, LDL receptor, and ABCA1) in the cell membrane, and sperm concentration (Project PI16/00154, ISCIII)