Translational cancer research
Our group has been focused for years on the identification, characterization and validation, through multidisciplinary approaches, of prognostic/predictive markers and potential therapeutic targets in tumors, in particular breast, gynecological carcinomas and sarcomas. An additional group goal is to gain insights into the molecular basis of chemo/radioresistance in cancer and to advance in the design of new, more effective and less toxic antitumor (nano)-therapies. Among our studies, we highlight those focused on analyzing the functional role in cancer of the chromosomal instability, cell cycle, mechanisms of cell death, intratumoral heterogeneity and the immune response to tumors.
Search for publications
Only original articles, editorials, guidelines.
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Monfort-Vengut A, Sanz-Gómez N, Ballesteros-Sánchez S, Ortigosa B, Cambón A, Ramos M, Lorenzo ÁM, Escribano-Cebrián M, Rosa-Rosa JM, Martínez-López J, Sánchez-Prieto R, Sotillo R, de Cárcer G.
Osmotic stress influences microtubule drug response via WNK1 kinase signaling.
DRUG RESISTANCE UPDATES . 79: 101203-101203.
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Morillo-Huesca M, G López-Cepero I, Conesa-Bakkali R, Tomé M, Watts C, Huertas P, Moreno-Bueno G, Durán RV, Martínez-Fábregas J.
Radiotherapy resistance driven by Asparagine endopeptidase through ATR pathway modulation in breast cancer.
Journal Of Experimental & Clinical Cancer Research . 44(1): 74-74.
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Rodriguez-Baena FJ, Marquez-Galera A, Ballesteros-Martinez P, Castillo A, Diaz E, Moreno-Bueno G, Lopez-Atalaya JP, Sanchez-Laorden B.
Microglial reprogramming enhances antitumor immunity and immunotherapy response in melanoma brain metastases.
Cancer Cell . : .