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Lipid metabolism

The Clinical and Applied Lipidomics for Metabolism Research Group investigates the role of lipids, particularly ceramides and cholesterol, in cardiometabolic, liver, and neurodegenerative diseases. Its activities integrate basic, translational, and clinical research, with a strong focus on the identification of biomarkers and the development of advanced lipidomics and metabolomics methodologies using mass spectrometry.

The group is supported by competitive national funding, has a strong international scientific publication record, and is currently developing a patent. In addition, it contributes to the Lipidomic and Proteomic Characterization Unit (UCA-CLP) and maintains strategic collaborations at both the national and international levels.

Search for publications

Only original articles, editorials, guidelines.

  • Stanescu, Sinziana, Belanger-Quintana, Amaya, Fernandez-Felix, Borja Manuel, Arrieta, Francisco, Quintero, Victor, Maldonado, Maria Soledad, Alcaide, Patricia, Martinez-Pardo, Mercedes.

    Severe anemia in patients with Propionic acidemia is associated with branched-chain amino acid imbalance

    Orphanet Journal of Rare Diseases . 16(1): 226-226. Number of citations: 7

    [doi:10.1186/s13023-021-01865-7]

  • Herrera-Martínez AD, Junquera-Bañares S, Turrión-Merino L, Arrieta-Blanco F, Botella-Carretero J, Vázquez-Martínez C, Calañas-Continente A.

    Case Report: Extensive Dermatitis Secondary to Severe Malnutrition, Zinc and Vitamin Deficiencies After Malabsorptive Bariatric Surgery

    Frontiers in Endocrinology . 12: 623543-623543. Number of citations: 4

    [doi:10.3389/fendo.2021.623543]

  • Canfran-Duque, Alberto, Pastor, Oscar, Garcia-Seisdedos, David, Molina, Yessenia L., Babiy, Bohdan, Lerma, Milagros, Sanchez-Castellano, Carmen, Martinez-Botas, Javier, Gomez-Coronado, Diego, Lasuncion, Miguel A., Cruz-Jentoft, Alfonso J., Busto, Rebeca.

    The Antipsychotic Risperidone Alters Dihydroceramide and Ceramide Composition and Plasma Membrane Function in Leukocytes In Vitro and In Vivo

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES . 22(8): 3919. Number of citations: 10

    [doi:10.3390/ijms22083919]

  • Yubero-Serrano, Elena M., Alcala-Diaz, Juan F., Gutierrez-Mariscal, Francisco M., Arenas-de Larriva, Antonio P., Peña-Orihuela PJ, Blanco-Rojo, Ruth, Martinez-Botas, Javier, Torres-Pena, Jose D., Perez-Martinez, Pablo, Ordovas, Jose M., Delgado-Lista, Javier, Gomez-Coronado, Diego, Lopez-Miranda, Jose.

    Association between cholesterol efflux capacity and peripheral artery disease in coronary heart disease patients with and without type 2 diabetes: from the CORDIOPREV study

    Cardiovascular Diabetology . 20(1): 72-72. Number of citations: 11

    [doi:10.1186/s12933-021-01260-3]

  • del Pozo-Acebo, Lorena, Hazas MLL, Tome-Carneiro, Joao, Gil-Cabrerizo, Paula, San-Cristobal, Rodrigo, Busto, Rebeca, Garcia-Ruiz, Almudena, Davalos, Alberto.

    Bovine Milk-Derived Exosomes as a Drug Delivery Vehicle for miRNA-Based Therapy

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES . 22(3): 1105. Number of citations: 173

    [doi:10.3390/ijms22031105]

  • Stanescu, Sinziana, Belanger-Quintana, Amaya, Fernandez-Felix, Borja Manuel, Perez-Cerda, Celia, Merinero, Begona, Ruiz-Sala, Pedro, Arrieta, Francisco, Martinez-Pardo, Mercedes.

    Long-term follow-up with filter paper samples in patients with propionic acidemia.

    JIMD Reports . 57(1): 44-51. Number of citations: 3

    [doi:10.1002/jmd2.12166]

  • Martínez-Botas J, Fernández-Lozano C, Rodríguez-Alonso A, Sánchez-Ruano L, de la Hoz B.

    Epitope Mapping of Food Allergens Using Noncontact Piezoelectric Microarray Printer

    Methods in molecular biology (Clifton, N.J.) . 2344: 119-135. Number of citations: 2

    [doi:10.1007/978-1-0716-1562-1_9]

  • San Bartolomé C, Oeo-Santos C, San Segundo-Acosta P, Muñoz-Cano R, Martínez-Botas J, Bartra J, Pascal M.

    Epitope Mapping of Allergenic Lipid Transfer Proteins

    Methods in molecular biology (Clifton, N.J.) . 2344: 107-117. Number of citations: 1

    [doi:10.1007/978-1-0716-1562-1_8]

  • Sancho-Knapik, Sara, Pastor, Oscar, Barranquero, Cristina, Herrera Marcos LV, Guillen, Natalia, Arnal, Carmen, Gascon, Sonia, Navarro, Maria A., Rodriguez-Yoldi, Maria J., Busto, Rebeca, Lasuncion, Miguel A., Osada, Jesus.

    Hepatic Synaptotagmin 1 is involved in the remodelling of liver plasma-membrane lipid composition and gene expression in male Apoe-deficient mice consuming a Western diet

    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS . 1865(12): 158790-158790. Number of citations: 7

    [doi:10.1016/j.bbalip.2020.158790]

  • Téllez L, Ibáñez-Samaniego L, Pérez Del Villar C, Yotti R, Martínez J, Carrión L, Rodríguez de Santiago E, Rivera M, González-Mansilla A, Pastor Ó, Bermejo J, Bañares R, Albillos A, Collaborators.

    Non-selective beta-blockers impair global circulatory homeostasis and renal function in cirrhotic patients with refractory ascites

    JOURNAL OF HEPATOLOGY . 73(6): 1404-1414. Number of citations: 81

    [doi:10.1016/j.jhep.2020.05.011]

  • Gil-Zamorano J, Tomé-Carneiro J, Lopez de Las Hazas MC, Del Pozo-Acebo L, Crespo MC, Gómez-Coronado D, Chapado LA, Herrera E, Latasa MJ, Ruiz-Roso MB, Castro-Camarero M, Briand O, Dávalos A.

    Intestinal miRNAs regulated in response to dietary lipids

    Scientific Reports . 10(1): 18921-18921. Number of citations: 15

    [doi:10.1038/s41598-020-75751-w]

  • Terrados S, Villafana L, Antolín-Amérigo D, Camarero C, Martínez-Botas J, Sánchez-Ruano L, de la Hoz B.

    Effectiveness of allergy testing in milk induced eosinophilic esophagitis. Description and follow-up of patients

    ALLERGOLOGIA ET IMMUNOPATHOLOGIA . 48(6): 576-581. Number of citations: 3

    [doi:10.1016/j.aller.2020.05.006]

  • Lopez-Neyra, Alejandro, Suarez, Lucretia, Munoz, Marta, de Blas, Ana, Ruiz de Valbuena M, Garriga, Maria, Calvo, Joaquim, Ribes, Carmen, Giron Moreno R, Maiz, Luis, Gonzalez, David, Bousono, Carlos, Manzanares, Javier, Pastor, Oscar, Martinez-Botas, Javier, del Campo, Rosa, Canton, Rafael, Roy, Garbine, Menacho, Miriam, Arroyo, David, Zamora, Javier, Soriano, Joan B., Lamas, Adelaida.

    Long-term docosahexaenoic acid (DHA) supplementation in cystic fibrosis patients: a randomized, multi-center, double-blind, placebo-controlled trial

    PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS . 162: 102186-102186. Number of citations: 14

    [doi:10.1016/j.plefa.2020.102186]

  • Arrieta, F, Pedro-Botet, J.

    Recognizing obesity as a disease: A true challenge.

    REVISTA CLINICA ESPANOLA . 221(9): 544-546. Number of citations: 10

    [doi:10.1016/j.rce.2020.08.003]

  • Alves, Ana Catarina, Alonso, Rodrigo, Diaz-Diaz, Jose Luis, Medeiros, Ana Margarida, Jannes, Cinthia E., Merchan, Alonso, Vasques-Cardenas, Norma A., Cuevas, Ada, Chacra, Ana Paula, Krieger, Jose E., Arroyo, Raquel, Arrieta, Francisco, Schreier, Laura, Corral, Pablo, Bañares VG, Araujo, Maria B., Bustos, Paula, Asenjo, Sylvia, Stoll, Mario, Dell'Oca, Nicolas, Reyes, Maria, Ressia, Andres, Campo, Rafael, Magaña-Torres MT, Metha, Roopa, Aguilar-Salinas, Carlos A., Ceballos-Macias, Jose J., Morales ÁJR, Mata, Pedro, Bourbon, Mafalda, Santos, Raul D..

    Phenotypical, Clinical, and Molecular Aspects of Adults and Children With Homozygous Familial Hypercholesterolemia in Iberoamerica

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY . 40(10): 2508-2515. Number of citations: 32

    [doi:10.1161/ATVBAHA.120.313722]

  • Perez de Isla, Leopoldo, Arroyo-Olivares, Raquel, Alonso, Rodrigo, Muniz-Grijalvo, Ovidio, Luis Diaz-Diaz, Jose, Zambon, Daniel, Fuentes, Francisco, Mata, Nelva, Piedecausa, Mar, Dolores Manas, M., Sanchez Munoz-Torrero, Juan F., Pablo Miramontes-Gonzalez, Jose, de Andres, Raimundo, Mauri, Marta, Aguado, Rocio, Brea, Angel, Cepeda, Jose M., Vidal-Pardo, I, Jose, Martinez-Faedo, Ceferino, Angel Barba, Miguel, Argueso, Rosa, Ruiz-Perez, Enrique, Michan, Alfredo, Arrieta, Francisco, Riestra Fernandez, Maria, Perez, Leire, Pinilla, Jose M., Diaz-Soto, Gonzalo, Pinto, Xavier, Padro, Teresa, Badimon, Lina, Mata, Pedro, Invest SAFEHEART.

    Incidence of cardiovascular events and changes in the estimated risk and treatment of familial hypercholesterolemia: the SAFEHEART registry

    REVISTA ESPANOLA DE CARDIOLOGIA . 73(10): 828-834. Number of citations: 11

    [doi:10.1016/j.recesp.2019.10.013]

  • Arola-Arnal, Anna, Lopez de las Hazas, Maria-Carmen, Iglesias-Carres, Lisard, Mantilla-Escalante, Diana C., Suarez, Manuel, Busto, Rebeca, Visioli, Francesco, Blade, Cinta, Davalos, Alberto.

    Exosomes transport trace amounts of (poly)phenols

    Food & Function . 11(9): 7784-7792. Number of citations: 9

    [doi:10.1039/d0fo01824d]

  • Arrieta Blanco F, Belanger Quintana A, Bengoa Rojano N, Stanescu S, Martinez Pardo M.

    GLUT1 and COVID-19 deficiency syndrome.

    Endocrinologia, diabetes y nutricion . 68(7): 514-515.

    [doi:10.1016/j.endinu.2020.07.001]