Aptamers
2025 Activity indicators
- 1 competitive European project led: ABSarbo (EULAC)
- 3 competitive national public projects: ISCIII, MICINN
- 2 private projects led
- 2 competitive HR contracts
- 6 publications
- FI: 36.60
- Publications in Q1: 3 (50%)
- Publications in D1: 2 (33%)
- Project evaluators for national institutions: 2 PIs and international institutions (Czech Science Foundation): 1 PI
- Editorial committee member: 1 PI
- 5 active patent families with priority patent:
- P201430955 "TLR4-specific aptamers and their potential use for stroke treatment." Entry into national phases in 15 countries
- P201930524 "FPR2 receptor agonist aptamers" with PCT/ES2020/070378 and entry into national phases in the US and Europe
- EP 18 382 888.8 "Specific aptamers against human MNK1 protein and their use in an MNK1 detection method and as an MNK1 inhibitor" with PCT/EP2019/083547 and entry into national phases in Europe and the US
- EP24382574.2 "OR2AT4 receptor agonist aptamers and uses thereof"
- EP24382233.5 "Nucleic acid aptamer for treatment of liver cancer" · An aptamer (ApTOLL), which has passed phases I/IIa for the treatment of stroke, has been licensed to Merck.
- An aptamer (ApTOLL), which has passed phase I/IIa clinical trials for stroke treatment, has been licensed to Merck.
- 5 visiting researchers were hosted for a total of 15.6 months: ATTENBIO; University of Beira Interior (Portugal); University of Naples Federico II (Italy); and University of São Paulo (Brazil).
Milestones
- Hosting of international researchers for training in aptamer technology.
- Establishment of a Scientific-Technical Service (SCT) for Cell Cultures at IRYCIS, coordinated by Dr. M. Elena Martín.
- Licensing of the ApTOLL aptamer, developed by our research group, to Merck by Aptatargets.
- Signing of five research contracts by UCA-Aptamers, formed from the research group and providing aptamer selection services to third parties, with one research group and three biotechnology companies.
- Award of a PFIS predoctoral contract (FI24/00127) in the AES2024 call for proposals.
Bibliometrics
| Articles | Accum. FI | Mean FI | Articles Q1 or Q2 | % in Q1 or Q2 | Articles D1 | % in D1 | |
|---|---|---|---|---|---|---|---|
| 2021 | 6 | 38.28 | 6.38 | 6 | 100 | 1 | 17 |
| 2022 | 8 | 50.99 | 6.34 | 6 | 75 | 1 | 12 |
| 2023 | 12 | 79.92 | 7.27 | 11 | 92 | 1 | 8 |
| 2024 | 11 | 44.10 | 4.01 | 9 | 82 | 1 | 9 |
| 2025 | 6 | 36.60 | 6.10 | 6 | 100 | 2 | 33 |
| 43 | 249.90 | 6.02 | 38 | 90 | 6 | 16 |
* Only original articles, editorials, guidelines and reviews